The infant gut virome is associated with preschool asthma risk independently of bacteria

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The infant gut virome is associated with preschool asthma risk independently of bacteria. / Rodríguez, Cristina Leal; Shah, Shiraz A.; Rasmussen, Morten Arendt; Thorsen, Jonathan; Boulund, Ulrika; Pedersen, Casper-Emil Tingskov; Castro-Mejía, Josué L.; Poulsen, Christina Egeø; Poulsen, Casper Sahl; Deng, Ling; Larsen, Frej Andreas Nøhr; Widdowson, Michael; Zhang, Yichang; Sørensen, Søren J.; Moineau, Sylvain; Petit, Marie Agnès; Chawes, Bo; Bønnelykke, Klaus; Nielsen, Dennis S.; Stokholm, Jakob.

I: Nature Medicine, Bind 30, 2023, s. 138-148.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Rodríguez, CL, Shah, SA, Rasmussen, MA, Thorsen, J, Boulund, U, Pedersen, C-ET, Castro-Mejía, JL, Poulsen, CE, Poulsen, CS, Deng, L, Larsen, FAN, Widdowson, M, Zhang, Y, Sørensen, SJ, Moineau, S, Petit, MA, Chawes, B, Bønnelykke, K, Nielsen, DS & Stokholm, J 2023, 'The infant gut virome is associated with preschool asthma risk independently of bacteria', Nature Medicine, bind 30, s. 138-148. https://doi.org/10.1038/s41591-023-02685-x

APA

Rodríguez, C. L., Shah, S. A., Rasmussen, M. A., Thorsen, J., Boulund, U., Pedersen, C-E. T., Castro-Mejía, J. L., Poulsen, C. E., Poulsen, C. S., Deng, L., Larsen, F. A. N., Widdowson, M., Zhang, Y., Sørensen, S. J., Moineau, S., Petit, M. A., Chawes, B., Bønnelykke, K., Nielsen, D. S., & Stokholm, J. (2023). The infant gut virome is associated with preschool asthma risk independently of bacteria. Nature Medicine, 30, 138-148. https://doi.org/10.1038/s41591-023-02685-x

Vancouver

Rodríguez CL, Shah SA, Rasmussen MA, Thorsen J, Boulund U, Pedersen C-ET o.a. The infant gut virome is associated with preschool asthma risk independently of bacteria. Nature Medicine. 2023;30:138-148. https://doi.org/10.1038/s41591-023-02685-x

Author

Rodríguez, Cristina Leal ; Shah, Shiraz A. ; Rasmussen, Morten Arendt ; Thorsen, Jonathan ; Boulund, Ulrika ; Pedersen, Casper-Emil Tingskov ; Castro-Mejía, Josué L. ; Poulsen, Christina Egeø ; Poulsen, Casper Sahl ; Deng, Ling ; Larsen, Frej Andreas Nøhr ; Widdowson, Michael ; Zhang, Yichang ; Sørensen, Søren J. ; Moineau, Sylvain ; Petit, Marie Agnès ; Chawes, Bo ; Bønnelykke, Klaus ; Nielsen, Dennis S. ; Stokholm, Jakob. / The infant gut virome is associated with preschool asthma risk independently of bacteria. I: Nature Medicine. 2023 ; Bind 30. s. 138-148.

Bibtex

@article{8a24f12e5dd740aa8e816a68665883af,
title = "The infant gut virome is associated with preschool asthma risk independently of bacteria",
abstract = "Bacteriophage (also known as phage) communities that inhabit the gut have a major effect on the structure and functioning of bacterial populations, but their roles and association with health and disease in early life remain unknown. Here, we analyze the gut virome of 647 children aged 1 year from the Copenhagen Prospective Studies on Asthma in Childhood2010 (COPSAC2010) mother–child cohort, all deeply phenotyped from birth and with longitudinally assessed asthma diagnoses. Specific temperate gut phage taxa were found to be associated with later development of asthma. In particular, the joint abundances of 19 caudoviral families were found to significantly contribute to this association. Combining the asthma-associated virome and bacteriome signatures had additive effects on asthma risk, implying an independent virome–asthma association. Moreover, the virome-associated asthma risk was modulated by the host TLR9 rs187084 gene variant, suggesting a direct interaction between phages and the host immune system. Further studies will elucidate whether phages, alongside bacteria and host genetics, can be used as preclinical biomarkers for asthma.",
author = "Rodr{\'i}guez, {Cristina Leal} and Shah, {Shiraz A.} and Rasmussen, {Morten Arendt} and Jonathan Thorsen and Ulrika Boulund and Pedersen, {Casper-Emil Tingskov} and Castro-Mej{\'i}a, {Josu{\'e} L.} and Poulsen, {Christina Ege{\o}} and Poulsen, {Casper Sahl} and Ling Deng and Larsen, {Frej Andreas N{\o}hr} and Michael Widdowson and Yichang Zhang and S{\o}rensen, {S{\o}ren J.} and Sylvain Moineau and Petit, {Marie Agn{\`e}s} and Bo Chawes and Klaus B{\o}nnelykke and Nielsen, {Dennis S.} and Jakob Stokholm",
note = "Publisher Copyright: {\textcopyright} 2023, The Author(s), under exclusive licence to Springer Nature America, Inc.",
year = "2023",
doi = "10.1038/s41591-023-02685-x",
language = "English",
volume = "30",
pages = "138--148",
journal = "Nature Medicine",
issn = "1078-8956",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - The infant gut virome is associated with preschool asthma risk independently of bacteria

AU - Rodríguez, Cristina Leal

AU - Shah, Shiraz A.

AU - Rasmussen, Morten Arendt

AU - Thorsen, Jonathan

AU - Boulund, Ulrika

AU - Pedersen, Casper-Emil Tingskov

AU - Castro-Mejía, Josué L.

AU - Poulsen, Christina Egeø

AU - Poulsen, Casper Sahl

AU - Deng, Ling

AU - Larsen, Frej Andreas Nøhr

AU - Widdowson, Michael

AU - Zhang, Yichang

AU - Sørensen, Søren J.

AU - Moineau, Sylvain

AU - Petit, Marie Agnès

AU - Chawes, Bo

AU - Bønnelykke, Klaus

AU - Nielsen, Dennis S.

AU - Stokholm, Jakob

N1 - Publisher Copyright: © 2023, The Author(s), under exclusive licence to Springer Nature America, Inc.

PY - 2023

Y1 - 2023

N2 - Bacteriophage (also known as phage) communities that inhabit the gut have a major effect on the structure and functioning of bacterial populations, but their roles and association with health and disease in early life remain unknown. Here, we analyze the gut virome of 647 children aged 1 year from the Copenhagen Prospective Studies on Asthma in Childhood2010 (COPSAC2010) mother–child cohort, all deeply phenotyped from birth and with longitudinally assessed asthma diagnoses. Specific temperate gut phage taxa were found to be associated with later development of asthma. In particular, the joint abundances of 19 caudoviral families were found to significantly contribute to this association. Combining the asthma-associated virome and bacteriome signatures had additive effects on asthma risk, implying an independent virome–asthma association. Moreover, the virome-associated asthma risk was modulated by the host TLR9 rs187084 gene variant, suggesting a direct interaction between phages and the host immune system. Further studies will elucidate whether phages, alongside bacteria and host genetics, can be used as preclinical biomarkers for asthma.

AB - Bacteriophage (also known as phage) communities that inhabit the gut have a major effect on the structure and functioning of bacterial populations, but their roles and association with health and disease in early life remain unknown. Here, we analyze the gut virome of 647 children aged 1 year from the Copenhagen Prospective Studies on Asthma in Childhood2010 (COPSAC2010) mother–child cohort, all deeply phenotyped from birth and with longitudinally assessed asthma diagnoses. Specific temperate gut phage taxa were found to be associated with later development of asthma. In particular, the joint abundances of 19 caudoviral families were found to significantly contribute to this association. Combining the asthma-associated virome and bacteriome signatures had additive effects on asthma risk, implying an independent virome–asthma association. Moreover, the virome-associated asthma risk was modulated by the host TLR9 rs187084 gene variant, suggesting a direct interaction between phages and the host immune system. Further studies will elucidate whether phages, alongside bacteria and host genetics, can be used as preclinical biomarkers for asthma.

U2 - 10.1038/s41591-023-02685-x

DO - 10.1038/s41591-023-02685-x

M3 - Journal article

C2 - 38102298

AN - SCOPUS:85179700363

VL - 30

SP - 138

EP - 148

JO - Nature Medicine

JF - Nature Medicine

SN - 1078-8956

ER -

ID: 379169565