Isolation and structural characterization of echinocystic acid triterpenoid saponins from the Australian medicinal and food plant Acacia ligulata

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Standard

Isolation and structural characterization of echinocystic acid triterpenoid saponins from the Australian medicinal and food plant Acacia ligulata. / Knudsen, Diana Jæger; Ndi, Chi P.; Crocoll, Christoph; Simpson, Bradley S.; Khakimov, Bekzod; Guzman-Genuino, Ruth Marian; Hayball, John D.; Xing, Xiaohui; Bulone, Vincent; Weinstein, Philip; Møller, Birger Lindberg; Semple, Susan J.

I: Journal of Natural Products, Bind 80, Nr. 10, 2017, s. 2692-2698.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Knudsen, DJ, Ndi, CP, Crocoll, C, Simpson, BS, Khakimov, B, Guzman-Genuino, RM, Hayball, JD, Xing, X, Bulone, V, Weinstein, P, Møller, BL & Semple, SJ 2017, 'Isolation and structural characterization of echinocystic acid triterpenoid saponins from the Australian medicinal and food plant Acacia ligulata', Journal of Natural Products, bind 80, nr. 10, s. 2692-2698. https://doi.org/10.1021/acs.jnatprod.7b00437

APA

Knudsen, D. J., Ndi, C. P., Crocoll, C., Simpson, B. S., Khakimov, B., Guzman-Genuino, R. M., Hayball, J. D., Xing, X., Bulone, V., Weinstein, P., Møller, B. L., & Semple, S. J. (2017). Isolation and structural characterization of echinocystic acid triterpenoid saponins from the Australian medicinal and food plant Acacia ligulata. Journal of Natural Products, 80(10), 2692-2698. https://doi.org/10.1021/acs.jnatprod.7b00437

Vancouver

Knudsen DJ, Ndi CP, Crocoll C, Simpson BS, Khakimov B, Guzman-Genuino RM o.a. Isolation and structural characterization of echinocystic acid triterpenoid saponins from the Australian medicinal and food plant Acacia ligulata. Journal of Natural Products. 2017;80(10):2692-2698. https://doi.org/10.1021/acs.jnatprod.7b00437

Author

Knudsen, Diana Jæger ; Ndi, Chi P. ; Crocoll, Christoph ; Simpson, Bradley S. ; Khakimov, Bekzod ; Guzman-Genuino, Ruth Marian ; Hayball, John D. ; Xing, Xiaohui ; Bulone, Vincent ; Weinstein, Philip ; Møller, Birger Lindberg ; Semple, Susan J. / Isolation and structural characterization of echinocystic acid triterpenoid saponins from the Australian medicinal and food plant Acacia ligulata. I: Journal of Natural Products. 2017 ; Bind 80, Nr. 10. s. 2692-2698.

Bibtex

@article{a3824ea777d14b649d548aa51037f3b9,
title = "Isolation and structural characterization of echinocystic acid triterpenoid saponins from the Australian medicinal and food plant Acacia ligulata",
abstract = "The Australian plant Acacia ligulata has a number of traditional food and medicinal uses by Australian Aboriginal people, although no bioactive compounds have previously been isolated from this species. Bioassay-guided fractionation of an ethanolic extract of the mature pods of A. ligulata led to the isolation of the two new echinocystic acid triterpenoid saponins, ligulatasides A (1) and B (2), which differ in the fine structure of their glycan substituents. Their structures were elucidated on the basis of 1D and 2D NMR, GC-MS, LC-MS/MS, and saccharide linkage analysis. These are the first isolated compounds from A. ligulata and the first fully elucidated structures of triterpenoid saponins from Acacia sensu stricto having echinocystic acid reported as the aglycone. Compounds 1 and 2 were evaluated for cytotoxic activity against a human melanoma cancer cell line (SK-MEL28) and a diploid fibroblast cell line (HFF), but showed only weak activity.",
keywords = "Journal Article",
author = "Knudsen, {Diana J{\ae}ger} and Ndi, {Chi P.} and Christoph Crocoll and Simpson, {Bradley S.} and Bekzod Khakimov and Guzman-Genuino, {Ruth Marian} and Hayball, {John D.} and Xiaohui Xing and Vincent Bulone and Philip Weinstein and M{\o}ller, {Birger Lindberg} and Semple, {Susan J.}",
year = "2017",
doi = "10.1021/acs.jnatprod.7b00437",
language = "English",
volume = "80",
pages = "2692--2698",
journal = "Journal of Natural Products",
issn = "0163-3864",
publisher = "American Chemical Society",
number = "10",

}

RIS

TY - JOUR

T1 - Isolation and structural characterization of echinocystic acid triterpenoid saponins from the Australian medicinal and food plant Acacia ligulata

AU - Knudsen, Diana Jæger

AU - Ndi, Chi P.

AU - Crocoll, Christoph

AU - Simpson, Bradley S.

AU - Khakimov, Bekzod

AU - Guzman-Genuino, Ruth Marian

AU - Hayball, John D.

AU - Xing, Xiaohui

AU - Bulone, Vincent

AU - Weinstein, Philip

AU - Møller, Birger Lindberg

AU - Semple, Susan J.

PY - 2017

Y1 - 2017

N2 - The Australian plant Acacia ligulata has a number of traditional food and medicinal uses by Australian Aboriginal people, although no bioactive compounds have previously been isolated from this species. Bioassay-guided fractionation of an ethanolic extract of the mature pods of A. ligulata led to the isolation of the two new echinocystic acid triterpenoid saponins, ligulatasides A (1) and B (2), which differ in the fine structure of their glycan substituents. Their structures were elucidated on the basis of 1D and 2D NMR, GC-MS, LC-MS/MS, and saccharide linkage analysis. These are the first isolated compounds from A. ligulata and the first fully elucidated structures of triterpenoid saponins from Acacia sensu stricto having echinocystic acid reported as the aglycone. Compounds 1 and 2 were evaluated for cytotoxic activity against a human melanoma cancer cell line (SK-MEL28) and a diploid fibroblast cell line (HFF), but showed only weak activity.

AB - The Australian plant Acacia ligulata has a number of traditional food and medicinal uses by Australian Aboriginal people, although no bioactive compounds have previously been isolated from this species. Bioassay-guided fractionation of an ethanolic extract of the mature pods of A. ligulata led to the isolation of the two new echinocystic acid triterpenoid saponins, ligulatasides A (1) and B (2), which differ in the fine structure of their glycan substituents. Their structures were elucidated on the basis of 1D and 2D NMR, GC-MS, LC-MS/MS, and saccharide linkage analysis. These are the first isolated compounds from A. ligulata and the first fully elucidated structures of triterpenoid saponins from Acacia sensu stricto having echinocystic acid reported as the aglycone. Compounds 1 and 2 were evaluated for cytotoxic activity against a human melanoma cancer cell line (SK-MEL28) and a diploid fibroblast cell line (HFF), but showed only weak activity.

KW - Journal Article

U2 - 10.1021/acs.jnatprod.7b00437

DO - 10.1021/acs.jnatprod.7b00437

M3 - Journal article

C2 - 28976773

VL - 80

SP - 2692

EP - 2698

JO - Journal of Natural Products

JF - Journal of Natural Products

SN - 0163-3864

IS - 10

ER -

ID: 184420941