Did circular DNA shape the evolution of mammalian genomes?
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Did circular DNA shape the evolution of mammalian genomes? / Holt, Sylvester; Arrey, Gerard; Regenberg, Birgitte.
I: Trends in Biochemical Sciences, Bind 48, Nr. 4, 2023.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Did circular DNA shape the evolution of mammalian genomes?
AU - Holt, Sylvester
AU - Arrey, Gerard
AU - Regenberg, Birgitte
PY - 2023
Y1 - 2023
N2 - Extrachromosomal circular DNA (eccDNA) can shape the genomes of somatic cells, but how it impacts genomes across generations is largely unexplored. We propose that genomes can rearrange via circular intermediates across generations and show that up to 6% of a mammalian genome can have changed gene order through eccDNA.
AB - Extrachromosomal circular DNA (eccDNA) can shape the genomes of somatic cells, but how it impacts genomes across generations is largely unexplored. We propose that genomes can rearrange via circular intermediates across generations and show that up to 6% of a mammalian genome can have changed gene order through eccDNA.
U2 - 10.1016/j.tibs.2022.09.010
DO - 10.1016/j.tibs.2022.09.010
M3 - Journal article
C2 - 36280496
VL - 48
JO - Trends in Biochemical Sciences
JF - Trends in Biochemical Sciences
SN - 0968-0004
IS - 4
ER -
ID: 323469109