Density fluctuations in saturated phospholipid bilayers increase as the acyl-chain length decreases

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

A systematic computer simulation study is conducted for a model of the main phase transition of fully hydrated saturated diacyl phosphatidylcholine bilayers (DMPC, DPPC, and DSPC). With particular focus on the fluctuation effects on the thermal properties in the transition region, the study yields data for the specific heat, the lateral compressibility, and the lipid-domain size distribution. Via a simple model assumption the transmembrane passive ion permeability is derived from the lipid-domain interfacial measure. A comparative analysis of the various data shows, in agreement with a number of experiments, that the lateral density fluctuations and hence the response functions increase as the acyl-chain length is decreased.

OriginalsprogEngelsk
TidsskriftBiophysical Journal
Vol/bind58
Udgave nummer5
Sider (fra-til)1099-1107
Antal sider9
ISSN0006-3495
DOI
StatusUdgivet - 1990
Eksternt udgivetJa

ID: 236894453