Calcium bioaccessibility as affected by strontium. Temperature effect on citrate binding to strontium and calcium alone and in combination
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Calcium bioaccessibility as affected by strontium. Temperature effect on citrate binding to strontium and calcium alone and in combination. / Liu, Xiao-Chen; Chen, Ruixia; Sun, Weizheng; Skibsted, Leif H.
In: Journal of Molecular Liquids, Vol. 396, 123961, 2024.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Calcium bioaccessibility as affected by strontium. Temperature effect on citrate binding to strontium and calcium alone and in combination
AU - Liu, Xiao-Chen
AU - Chen, Ruixia
AU - Sun, Weizheng
AU - Skibsted, Leif H.
N1 - Publisher Copyright: © 2024 The Author(s)
PY - 2024
Y1 - 2024
N2 - Strontium as a bone health promoter was found to increase the bioaccessibility of essential calcium from solid calcium citrate tetrahydrate in aqueous suspensions. This is unexpected since calcium citrate binds calcium stronger than strontium with ΔH0ass,c = 5.07 kJ⋅mol−1, ΔS0ass,c = 78.0 J⋅mol−1⋅K−1 for 1:1 Ca-Citrate complex formation and ΔH0ass,c = 1.67 kJ⋅mol−1, ΔS0ass,c = 58.3 J⋅mol−1⋅K−1 for 1:1 Sr-Citrate complex formation as determined both electrochemically and by isothermal titration calorimetry. Calcium citrate tetrahydrate has reverse solubility around physiological temperature in contrast to strontium citrate pentahydrate. This difference results in opposite effect of strontium upon calcium ion liberation from calcium citrate suspensions at both low and high temperature compared to physiological temperature, for which strontium was found to stabilize solid calcium citrate tetrahydrate. This effect, confirmed by quantum mechanical calculation and by comparison of spontaneous aqueous supersaturation of calcium citrate and strontium citrate, is suggested to be involved in the positive effect of strontium on bone and teeth health. The conclusions provide a theoretical foundation for the research of molecular mechanisms among calcium, strontium, and citrate ions in relation to bone and teeth health.
AB - Strontium as a bone health promoter was found to increase the bioaccessibility of essential calcium from solid calcium citrate tetrahydrate in aqueous suspensions. This is unexpected since calcium citrate binds calcium stronger than strontium with ΔH0ass,c = 5.07 kJ⋅mol−1, ΔS0ass,c = 78.0 J⋅mol−1⋅K−1 for 1:1 Ca-Citrate complex formation and ΔH0ass,c = 1.67 kJ⋅mol−1, ΔS0ass,c = 58.3 J⋅mol−1⋅K−1 for 1:1 Sr-Citrate complex formation as determined both electrochemically and by isothermal titration calorimetry. Calcium citrate tetrahydrate has reverse solubility around physiological temperature in contrast to strontium citrate pentahydrate. This difference results in opposite effect of strontium upon calcium ion liberation from calcium citrate suspensions at both low and high temperature compared to physiological temperature, for which strontium was found to stabilize solid calcium citrate tetrahydrate. This effect, confirmed by quantum mechanical calculation and by comparison of spontaneous aqueous supersaturation of calcium citrate and strontium citrate, is suggested to be involved in the positive effect of strontium on bone and teeth health. The conclusions provide a theoretical foundation for the research of molecular mechanisms among calcium, strontium, and citrate ions in relation to bone and teeth health.
KW - Calcium bioaccessibility
KW - Density Functional Theory calculation
KW - Entropy controlled reaction
KW - Speciation
KW - Spontaneous supersaturation
KW - Strontium citrate
U2 - 10.1016/j.molliq.2024.123961
DO - 10.1016/j.molliq.2024.123961
M3 - Journal article
AN - SCOPUS:85183626707
VL - 396
JO - Journal of Molecular Liquids
JF - Journal of Molecular Liquids
SN - 0167-7322
M1 - 123961
ER -
ID: 382896059