Bekzod Khakimov

Bekzod Khakimov

Associate Professor


  1. 2012
  2. Published

    Plant metabolomics: resolution and quantification of elusive peaks in liquid chromatography–mass spectrometry profiles of complex plant extracts using multi-way decomposition methods

    Khakimov, Bekzod, Amigo Rubio, J. M., Bak, Søren & Engelsen, Søren Balling, 2012, In: Journal of Chromatography A. 1266, p. 84-94 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Plante-metabolomics: opdagelse af nye bioaktive stoffer med PARAFAC2

    Khakimov, Bekzod, Engelsen, Søren Balling, Bro, Rasmus & Nørgaard, L., 2012, In: Dansk Kemi. 93, 12, p. 29-31 3 p.

    Research output: Contribution to journalJournal articleResearch

  4. Published

    UDP-glycosyltransferases from the UGT73C subfamily in Barbarea vulgaris catalyse Sapogenin 3-O-glucosylation in Saponin-mediated Insect resistance

    Augustin, J. M., Drok, S., Shinoda, T., Sanmiya, K., Nielsen, J. K., Khakimov, Bekzod, Olsen, C. E., Hansen, E. H., Poulsen, V. K., Ekstrøm, Claus Thorn, Hauser, T. P. & Bak, Søren, 2012, In: Plant Physiology. 160, 4, p. 1881-1895 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. 2013
  6. Published

    Metabolomics and bioactive substances in plants

    Khakimov, Bekzod, 2013, Department of Food Science, University of Copenhagen. 262 p.

    Research output: Book/ReportPh.D. thesisResearch

  7. Published

    The use of trimethylsilyl cyanide derivatization for robust and broad-spectrum high-throughput gas chromatography–mass spectrometry based metabolomics

    Khakimov, Bekzod, Motawie, Mohammed Saddik, Bak, Søren & Engelsen, Søren Balling, 2013, In: Analytical and Bioanalytical Chemistry. 405, 28, p. 9193-9205 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. 2014
  9. Published
  10. Published

    High-throughput cereal metabolomics: current analytical technologies, challenges and perspectives

    Khakimov, Bekzod, Bak, Søren & Engelsen, Søren Balling, 2014, In: Journal of Cereal Science. 59, 3, p. 393-418 26 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. 2015
  12. Published

    Identification and genome organization of saponin pathway genes from a wild crucifer, and their use for transient production of saponins in Nicotiana benthamiana

    Khakimov, Bekzod, Poulsen, V. K., Erthmann, P. Ø., Fukushima, E. O., Augustin, J. M., Olsen, C. E., Scholtalbers, J., Volpin, H., Andersen, S. B., Hauser, T. P., Muranaka, T. & Bak, Søren, 2015, In: The Plant Journal. 84, 3, p. 478-490 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Trends in the application of chemometrics to foodomics studies

    Khakimov, Bekzod, Gürdeniz, G. & Engelsen, Søren Balling, 2015, In: Acta Alimentaria. 44, 1, p. 4-31 28 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. 2016
  15. Published

    A comprehensive and comparative GC-MS metabolomics study of non-volatiles in Tanzanian grown mango, pineapple, jackfruit, baobab and tamarind fruits

    Khakimov, Bekzod, Mongi, R. J., Sørensen, Klavs Martin, Ndabikunze, B. K., Chove, B. E. & Engelsen, Søren Balling, 2016, In: Food Chemistry. 213, p. 691-699 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published
  17. Published

    GC-MS metabolite profiling of extreme southern Pinot noir wines: effects of vintage, barrel maturation, and fermentation dominate over vineyard site and clone selection

    Schueuermann, C., Khakimov, Bekzod, Engelsen, Søren Balling, Bremer, P. & Silcock, P., 2016, In: Journal of Agricultural and Food Chemistry. 64, 11, p. 2342-2351 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Lepidopteran defence droplets - a composite physical and chemical weapon against potential predators

    Pentzold, S., Zagrobelny, Mika, Khakimov, Bekzod, Engelsen, Søren Balling, Clausen, Henrik, Petersen, Bent L, Borch, J., Møller, Birger Lindberg & Bak, Søren, 2016, In: Scientific Reports. 6, 11 p., 22407 .

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    New Nordic diet versus average Danish diet: a randomized controlled trial revealed healthy long-term effects of the new Nordic diet by GC-MS blood plasma metabolomics

    Khakimov, Bekzod, Poulsen, S. K., Savorani, F., Evrim, A. A., Gürdeniz, G., Larsen, T. M., Astrup, A., Dragsted, Lars Ove & Engelsen, Søren Balling, 2016, In: Journal of Proteome Research. 15, 6, p. 1939-1954 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Screening for triterpenoid saponins in plants using hyphenated analytical platforms

    Khakimov, Bekzod, Tseng, L. H., Godejohann, M., Bak, Søren & Engelsen, Søren Balling, 2016, In: Molecules. 21, 12, 19 p., 1614.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    The use of rapid spectroscopic screening methods to detect adulteration of food raw materials and ingredients

    Sørensen, Klavs Martin, Khakimov, Bekzod & Engelsen, Søren Balling, 2016, In: Current Opinion in Food Science. 10, p. 45-51 7 p.

    Research output: Contribution to journalReviewResearchpeer-review

  22. 2017
  23. Published

    Antibiotic treatment preventing necrotising enterocolitis alters urinary and plasma metabolomes in preterm pigs

    Jiang, Pingping, Trimigno, A., Stanstrup, Jan, Khakimov, Bekzod, Viereck, Nanna, Engelsen, Søren Balling, Sangild, Per Torp & Dragsted, Lars Ove, 2017, In: Journal of Proteome Research. 16, p. 3547-3557 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    From metabolome to phenotype: GC-MS metabolomics of developing mutant barley seeds reveals effects of growth, temperature and genotype

    Khakimov, Bekzod, Rasmussen, Morten Arendt, Kannangara, R. M., Jespersen, Birthe P Møller, Munck, L. & Engelsen, Søren Balling, 2017, In: Scientific Reports. 7, 1, 12 p., 8195.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Gas chromatography – mass spectrometry data processing made easy

    Johnsen, L. G., Skou, P. B., Khakimov, Bekzod & Bro, Rasmus, 2017, In: Journal of Chromatography A. 1503, p. 57-64 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Identification of weak and gender specific effects in a short 3 weeks intervention study using barley and oat mixed linkage β-glucan dietary supplements: a human fecal metabolome study by GC-MS

    Trimigno, A., Khakimov, Bekzod, Castro Mejia, J. L., Mikkelsen, M. S., Kristensen, M. B., Jespersen, Birthe P Møller & Engelsen, Søren Balling, 2017, In: Metabolomics. 13, 13 p., 108.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Isolation and structural characterization of echinocystic acid triterpenoid saponins from the Australian medicinal and food plant Acacia ligulata

    Knudsen, D. J., Ndi, C. P., Crocoll, C., Simpson, B. S., Khakimov, Bekzod, Guzman-Genuino, R. M., Hayball, J. D., Xing, X., Bulone, V., Weinstein, P., Møller, Birger Lindberg & Semple, S. J., 2017, In: Journal of Natural Products. 80, 10, p. 2692-2698 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Quantification of lipoprotein profiles by nuclear magnetic resonance spectroscopy and multivariate data analysis

    Aru, Violetta, Lam, C., Khakimov, Bekzod, Hoefsloot, H. C. J., Zwanenburg, G., Lind, M. V., Schäfer, H., van Duynhoven, J., Jacobs, D. M., Smilde, A. K. & Engelsen, Søren Balling, 2017, In: Trends in Analytical Chemistry. 94, p. 210-219 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Quinoa seed coats as an expanding and sustainable source of bioactive compounds: an investigation of genotypic diversity in saponin profiles

    Ruiz, K. B., Khakimov, Bekzod, Engelsen, Søren Balling, Bak, Søren, Biondi, S. & Jacobsen, S., 2017, In: Industrial Crops and Products. 104, p. 156-163 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Resveratrol in the foodomics era: 1:25,000

    Khakimov, Bekzod & Engelsen, Søren Balling, 2017, In: New York Academy of Sciences. Annals. 1403, 1, p. 48-58 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Toward Reliable Lipoprotein Particle Predictions from NMR Spectra of Human Blood: An Interlaboratory Ring Test

    Centelles, S. M., Hoefsloot, H. C. J., Khakimov, Bekzod, Ebrahimi, Parvaneh, Lind, M. V., Kristensen, M., de Roo, N., Jacobs, D. M., van Duynhoven, J., Gannet, C., Fang, F., Humpfer, E., Schaefer, H., Spraul, M., Engelsen, Søren Balling & Smilde, A. K., 2017, In: Analytical Chemistry. 89, 15, p. 8004-8012 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Untargeted GC-MS Metabolomics Reveals Changes in the Metabolite Dynamics of Industrial Scale Batch Fermentations of Streptoccoccus thermophilus Broth

    Khakimov, Bekzod, Christiansen, L. D., Heins, A., Sørensen, Klavs Martin, Scholler, C., Clausen, A., Skov, T., Gernaey, K. V. & Engelsen, Søren Balling, 2017, In: Biotechnology Journal. 12, 10, 9 p., 1700400.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. 2018
  34. Published

    A Single Oxidosqualene Cyclase Produces the Seco-Triterpenoid α-Onocerin

    Almeida, A., Dong, L., Khakimov, Bekzod, Bassard, J. A., Moses, T., Lota, F., Goossens, A., Appendino, G. & Bak, Søren, 2018, In: Plant Physiology. 176, 2, p. 1469-1484 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Biogenic amines: a key freshness parameter of animal protein products in the coming circular economy

    Sørensen, Klavs Martin, Aru, Violetta, Khakimov, Bekzod, Aunskjaer, U. & Engelsen, Søren Balling, 2018, In: Current Opinion in Food Science. 22, p. 167-173

    Research output: Contribution to journalReviewResearchpeer-review

  36. Published
  37. Published

    Co-expression of squalene epoxidases with triterpene cyclases boosts production of triterpenoids in plants and yeast

    Dong, L., Pollier, J., Bassard, J., Ntallas, G., Almeida, A., Lazaridi, E., Khakimov, Bekzod, Arendt, P., de Oliveira, L. S., Lota, F., Goossens, A., Michoux, F. & Bak, Søren, 2018, In: Metabolic Engineering. 49, p. 1-12

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    CoMiniGut - a small volume in vitro colon model for the screening of gut microbial fermentation processes

    Wiese, M., Khakimov, Bekzod, Nielsen, S., Sørensen, H., van der Berg, Franciscus Winfried J & Nielsen, Dennis Sandris, 2018, In: PeerJ. 6, 22 p., e4268.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Cool-climate red wines - Chemical Composition and Camparison of two protocols for 1H-NMR Analysis

    Aru, Violetta, Sørensen, Klavs Martin, Khakimov, Bekzod, Toldam-Andersen, Torben & Engelsen, Søren Balling, 2018, In: Molecules. 23, 160, p. 1-18 18 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    NMR Foodomics

    Savorani, F., Khakimov, Bekzod, Viereck, Nanna & Engelsen, Søren Balling, 2018, NMR-based Metabolomics. Keun, H. C. (ed.). Royal Society of Chemistry, p. 183-245 63 p. (New Developments in NMR, Vol. 14).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  41. Published

    The foodome of bivalve molluscs: From hedonic eating to healthy diet

    Aru, Violetta, Khakimov, Bekzod, Sørensen, Klavs Martin & Engelsen, Søren Balling, 2018, In: Journal of Food Composition and Analysis. 69, p. 13-19 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. 2019
  43. Published

    Biomarkers of individual foods, and separation of diets using untargeted LC-MS-based plasma metabolomics in a randomized controlled trial

    Acar, E., Gürdeniz, G., Khakimov, Bekzod, Savorani, F., Korndal, S. K., Larsen, T. M., Engelsen, Søren Balling, Astrup, A. & Dragsted, Lars Ove, 2019, In: Molecular Nutrition & Food Research. 63, 1, 10 p., 1800215.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published
  45. Published

    Investigation of Variations in the Human Urine Metabolome amongst European Populations: An Exploratory Search for Biomarkers of People at Risk-of-Poverty

    Trimigno, A., Khakimov, Bekzod, Savorani, F., Tenori, L., Hendrixson, V., Civilis, A., Glibetic, M., Gurinovic, M., Pentikäinen, S., Sallinen, J., Diaz, S. G., Pasqui, F., Khokhar, S., Luchinat, C., Bordoni, A., Capozzi, F. & Engelsen, Søren Balling, 2019, In: Molecular Nutrition & Food Research. 63, 1, p. 1-11 1800216.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    The effect of charcoal on medicinal compounds of seeds of fenugreek (Trigonella foenum-graecum L.) exposed to drought stress

    Bitarafan, Z., Asghari, H. R., Hasanloo, T., Gholami, A., Moradi, F., Khakimov, Bekzod, Liu, Fulai & Andreasen, Christian, 2019, In: Industrial Crops and Products. 131, p. 323-329

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    The cytochrome P450 CYP72A552 is key to production of hederagenin‐based saponins that mediate plant defense against herbivores

    Liu, Q., Khakimov, Bekzod, Cárdenas, Pablo D., Cozzi, F., Olsen, C. E., Jensen, Karen Rysbjerg, Hauser, T. P. & Bak, Søren, May 2019, In: New Phytologist (Online). 222, 3, p. 1599-1609

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. 2020
  49. Published

    A Multi-Omics Approach Reveals New Signatures in Obese Allergic Asthmatic Children

    Gomez-Llorente, M. A., Martínez-Cañavate, A., Chueca, N., Rico, M. D. L. C., Romero, R., Anguita-Ruiz, A., Aguilera, C. M., Gil-Campos, M., Mesa, M. D., Khakimov, Bekzod, Morillo, J. A., Gil, Á., Camacho, J. & Gomez-Llorente, C., 2020, In: Biomedicines. 8, 9, 16 p., 359.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Comparison of statistical methods for predicting penetration capacity of drugs into human breast milk using physicochemical, pharmacokinetic and chromatographic descriptors

    Wanat, K., Khakimov, Bekzod & Brzezinska, E., 2020, In: SAR and QSAR in Environmental Research. 31, 6, p. 457-475 19 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published
  52. Published

    Human Faecal 1H NMR Metabolomics: Evaluation of Solvent and Sample Processing on Coverage and Reproducibility of Signature Metabolites

    Cui, M., Trimigno, A., Aru, Violetta, Khakimov, Bekzod & Engelsen, Søren Balling, 2020, In: Analytical Chemistry. 92, 14, p. 9546-9555 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    Human urine 1H NMR metabolomics reveals alterations of the protein and carbohydrate metabolism when comparing habitual Average Danish diet vs. healthy New Nordic diet

    Trimigno, A., Khakimov, Bekzod, Savorani, F., Poulsen, S. K., Astrup, A., Dragsted, Lars Ove & Engelsen, Søren Balling, 2020, In: Nutrition. 79-80, 11 p., 110867.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    IDDF2020-ABS-0174 Onset of hypertriglyceridemia in relation to dietary intake, gut microbiome and metabolomics signatures among home dwelling elderly

    Ahmad, H. F., Mejia, J. L. C., Krych, Lukasz, Khakimov, Bekzod, Kot, W., Bechshoft, R. L., Reitelseder, S., Engelsen, Søren Balling, Holm, L. & Faust, K., 2020, In: Gut. 69, Suppl 2, p. A21-A21 1 p.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  55. Published

    Physical fitness in community-dwelling older adults is linked to dietary intake, gut microbiota, and metabolomic signatures

    Castro-Mejia, J. L., Khakimov, B., Krych, L., Bülow, J., Bechshøft, R. L., Højfeldt, G., Mertz, K. H., Garne, E. S., Schacht, S. R., Ahmad, H. F., Kot, W., Hansen, L. H., Perez-Cueto, F. J. A., Lind, M. V., Lassen, A. J., Tetens, I., Jensen, T., Reitelseder, S., Jespersen, A. P., Holm, L. & 2 others, Engelsen, Søren Balling & Nielsen, Dennis Sandris, 2020, In: Aging Cell. 19, 3, 13 p., e13105.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Published

    Signature Mapping (SigMa): an efficient approach for processing complex human urine 1H NMR metabolomics data

    Khakimov, Bekzod, Mobaraki, N., Trimigno, A., Aru, Violetta & Engelsen, Søren Balling, 2020, In: Analytica Chimica Acta. 1108, p. 142-151 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. Published

    Structurally different mixed linkage β-glucan supplements differentially increase secondary bile acid excretion in hypercholesterolaemic rat faeces

    Iaccarino, N., Khakimov, Bekzod, Mikkelsen, M. S., Nielsen, T. S., Jensen, M. G., Randazzo, A. & Engelsen, Søren Balling, 2020, In: Food & Function. 11, 1, p. 514-523

    Research output: Contribution to journalJournal articleResearchpeer-review

  58. Published

    Synthetic Biology of Cannabinoids and Cannabinoid Glucosides in Nicotiana benthamiana and Saccharomyces cerevisiae

    Gülck, T., Booth, J. K., Carvalho, Â., Khakimov, Bekzod, Crocoll, C., Motawie, Mohammed Saddik, Møller, Birger Lindberg, Bohlmann, J. & Gallage, N. J., 2020, In: Journal of Natural Products. 83, 10, p. 2877-2893 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  59. 2021
  60. Published

    An independent evolutionary origin for insect deterrent cucurbitacins in Iberis amara

    Dong, L., Almeida Robles, A. R., Pollier, J., Khakimov, Bekzod, Bassard, J. A., Miettinen, K., Stærk, Dan, Mehran, R., Olsen, C. E., Motawie, Mohammed Saddik, Goossens, A. & Bak, Søren, 2021, In: Molecular Biology and Evolution. 38, 11, p. 4659-4673 15 p., msab213.

    Research output: Contribution to journalJournal articleResearchpeer-review

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