The effect of sucrase-isomaltase deficiency on metabolism, food intake and preferences: protocol for a dietary intervention study

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  • Ninna Karsbæk Senftleber
  • Kristine Skøtt Pedersen
  • Cecilie Schnoor Jørgensen
  • Hanne Pedersen
  • Marie Mathilde Bjerg Christensen
  • Emilie Kabel Madsen
  • Kristine Andersen
  • Emil Jørsboe
  • Matthew Paul Gillum
  • Frøst, Michael Bom
  • Hansen, Torben
  • Marit Eika Jørgensen

In Greenland, traditional marine foods are increasingly being replaced by sucrose- and starch-rich foods. A knock-out c.273_274delAG variant in the sucrase-isomaltase (SI) gene is relatively common in Greenland, with homozygous carriers being unable to digest sucrose and some starch. The variant is associated with a healthier metabolic phenotype in Greenlanders, which is confirmed by SI-knockout mice. We aim to assess if the healthy phenotype is explained by metabolic and microbial differences and if food and taste preferences differ between SI-genotypes. This paper describes the protocol for a randomised cross-over trial conducted in Greenland in 2022 with two dietary interventions of three days; a traditional meat- and fish-rich diet and a starch-rich Western diet with 11 energy% sucrose. The power calculation showed that 22 homozygous SI-carriers and 22 non-carriers were sufficient to detect a 0.5 mmol/L difference in glycaemic variability (80% power, α=0.05). We enrolled 18 carriers and 20 non-carriers. We examined food preferences at baseline and collected samples before and after each intervention for metabolic, metabolome, and microbiome profiling. Analyses of samples have not been completed yet. The Ethics Committee of Greenland approved the study. Results will be disseminated in international peer-reviewed journals and to the general Greenlandic population. NCT05375656.

Original languageEnglish
Article number2178067
JournalInternational Journal of Circumpolar Health
Issue number1
Number of pages10
Publication statusPublished - 2023

Bibliographical note

Funding Information:
The study is funded by the Independent Research Fund Denmark (grant no. 1030-00363B), The Greenland Institute of Natural Resources (postdoctoral grant number 80.045), and The Greenlandic Research Council (research grant not numbered). Brugseni sponsored all foods for the dietary intervention and the ad libitum meal test.

Publisher Copyright:
© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

    Research areas

  • Congenital sucrase-isomaltase deficiency, dietary intervention, food preferences, greenland, inuit diet, metabolism, microbiota

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