Clinical Saccharomyces cerevisiae isolates cannot cross the epithelial barrier in vitro

Research output: Contribution to journalJournal articlepeer-review

  • Roberto Pérez-Torrado
  • Silvia Llopis
  • Jespersen, Lene
  • Teresa Fernández-Espinar
  • Amparo Querol

Saccharomyces cerevisiae is generally considered to be a safe organism and is essential to produce many different kinds of foods as well as being widely used as a dietary supplement. However, several isolates, which are genetically related to brewing and baking yeasts, have shown virulent traits, being able to produce human infections in immunodeficient patients. Previously it has been shown that the administration of S. cerevisiae clinical isolates can lead to systemic infections, reaching several organs in murine systems. In this work, we studied S. cerevisiae clinical isolates in an in vitro intestinal epithelialbarrier model, comparing their behaviour with that of several strains of the related pathogens Candida glabrata and Candida albicans. The results showed that, in contrast to C. glabrata and C. albicans, S. cerevisiae was not able to cross the intestinal barrier. We concluded that S. cerevisiae can only perform opportunistic or passive crossings when epithelialbarrier integrity is previously compromised.

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Original languageEnglish
JournalInternational Journal of Food Microbiology
Volume157
Issue number1
Pages (from-to)59-64
Number of pages6
ISSN0168-1605
DOIs
Publication statusPublished - 2012

ID: 40977886