Clinical Saccharomyces cerevisiae isolates cannot cross the epithelial barrier in vitro

Research output: Contribution to journalJournal articlepeer-review

Standard

Clinical Saccharomyces cerevisiae isolates cannot cross the epithelial barrier in vitro. / Pérez-Torrado, Roberto; Llopis, Silvia; Jespersen, Lene; Fernández-Espinar, Teresa; Querol, Amparo.

In: International Journal of Food Microbiology, Vol. 157, No. 1, 2012, p. 59-64.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Pérez-Torrado, R, Llopis, S, Jespersen, L, Fernández-Espinar, T & Querol, A 2012, 'Clinical Saccharomyces cerevisiae isolates cannot cross the epithelial barrier in vitro', International Journal of Food Microbiology, vol. 157, no. 1, pp. 59-64. https://doi.org/10.1016/j.ijfoodmicro.2012.04.012

APA

Pérez-Torrado, R., Llopis, S., Jespersen, L., Fernández-Espinar, T., & Querol, A. (2012). Clinical Saccharomyces cerevisiae isolates cannot cross the epithelial barrier in vitro. International Journal of Food Microbiology, 157(1), 59-64. https://doi.org/10.1016/j.ijfoodmicro.2012.04.012

Vancouver

Pérez-Torrado R, Llopis S, Jespersen L, Fernández-Espinar T, Querol A. Clinical Saccharomyces cerevisiae isolates cannot cross the epithelial barrier in vitro. International Journal of Food Microbiology. 2012;157(1):59-64. https://doi.org/10.1016/j.ijfoodmicro.2012.04.012

Author

Pérez-Torrado, Roberto ; Llopis, Silvia ; Jespersen, Lene ; Fernández-Espinar, Teresa ; Querol, Amparo. / Clinical Saccharomyces cerevisiae isolates cannot cross the epithelial barrier in vitro. In: International Journal of Food Microbiology. 2012 ; Vol. 157, No. 1. pp. 59-64.

Bibtex

@article{caa1c63580984a21a20770b8bb7487fe,
title = "Clinical Saccharomyces cerevisiae isolates cannot cross the epithelial barrier in vitro",
abstract = "Saccharomyces cerevisiae is generally considered to be a safe organism and is essential to produce many different kinds of foods as well as being widely used as a dietary supplement. However, several isolates, which are genetically related to brewing and baking yeasts, have shown virulent traits, being able to produce human infections in immunodeficient patients. Previously it has been shown that the administration of S. cerevisiae clinical isolates can lead to systemic infections, reaching several organs in murine systems. In this work, we studied S. cerevisiae clinical isolates in an in vitro intestinal epithelialbarrier model, comparing their behaviour with that of several strains of the related pathogens Candida glabrata and Candida albicans. The results showed that, in contrast to C. glabrata and C. albicans, S. cerevisiae was not able to cross the intestinal barrier. We concluded that S. cerevisiae can only perform opportunistic or passive crossings when epithelialbarrier integrity is previously compromised. --------------------------------------------------------------------------------",
author = "Roberto P{\'e}rez-Torrado and Silvia Llopis and Lene Jespersen and Teresa Fern{\'a}ndez-Espinar and Amparo Querol",
year = "2012",
doi = "10.1016/j.ijfoodmicro.2012.04.012",
language = "English",
volume = "157",
pages = "59--64",
journal = "International Journal of Food Microbiology",
issn = "0168-1605",
publisher = "Elsevier",
number = "1",

}

RIS

TY - JOUR

T1 - Clinical Saccharomyces cerevisiae isolates cannot cross the epithelial barrier in vitro

AU - Pérez-Torrado, Roberto

AU - Llopis, Silvia

AU - Jespersen, Lene

AU - Fernández-Espinar, Teresa

AU - Querol, Amparo

PY - 2012

Y1 - 2012

N2 - Saccharomyces cerevisiae is generally considered to be a safe organism and is essential to produce many different kinds of foods as well as being widely used as a dietary supplement. However, several isolates, which are genetically related to brewing and baking yeasts, have shown virulent traits, being able to produce human infections in immunodeficient patients. Previously it has been shown that the administration of S. cerevisiae clinical isolates can lead to systemic infections, reaching several organs in murine systems. In this work, we studied S. cerevisiae clinical isolates in an in vitro intestinal epithelialbarrier model, comparing their behaviour with that of several strains of the related pathogens Candida glabrata and Candida albicans. The results showed that, in contrast to C. glabrata and C. albicans, S. cerevisiae was not able to cross the intestinal barrier. We concluded that S. cerevisiae can only perform opportunistic or passive crossings when epithelialbarrier integrity is previously compromised. --------------------------------------------------------------------------------

AB - Saccharomyces cerevisiae is generally considered to be a safe organism and is essential to produce many different kinds of foods as well as being widely used as a dietary supplement. However, several isolates, which are genetically related to brewing and baking yeasts, have shown virulent traits, being able to produce human infections in immunodeficient patients. Previously it has been shown that the administration of S. cerevisiae clinical isolates can lead to systemic infections, reaching several organs in murine systems. In this work, we studied S. cerevisiae clinical isolates in an in vitro intestinal epithelialbarrier model, comparing their behaviour with that of several strains of the related pathogens Candida glabrata and Candida albicans. The results showed that, in contrast to C. glabrata and C. albicans, S. cerevisiae was not able to cross the intestinal barrier. We concluded that S. cerevisiae can only perform opportunistic or passive crossings when epithelialbarrier integrity is previously compromised. --------------------------------------------------------------------------------

U2 - 10.1016/j.ijfoodmicro.2012.04.012

DO - 10.1016/j.ijfoodmicro.2012.04.012

M3 - Journal article

C2 - 22609000

VL - 157

SP - 59

EP - 64

JO - International Journal of Food Microbiology

JF - International Journal of Food Microbiology

SN - 0168-1605

IS - 1

ER -

ID: 40977886