Did circular DNA shape the evolution of mammalian genomes?
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Extrachromosomal circular DNA (eccDNA) can shape the genomes of somatic cells, but how it impacts genomes across generations is largely unexplored. We propose that genomes can rearrange via circular intermediates across generations and show that up to 6% of a mammalian genome can have changed gene order through eccDNA.
Original language | English |
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Journal | Trends in Biochemical Sciences |
Volume | 48 |
Issue number | 4 |
Number of pages | 4 |
ISSN | 0968-0004 |
DOIs | |
Publication status | Published - 2023 |
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