The half-life and exposure of cefuroxime varied in newborn infants after a Caesarean section
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
The half-life and exposure of cefuroxime varied in newborn infants after a Caesarean section. / Zachariassen, G.; Hyldig, N.; Joergensen, J.S.; Nielsen, Dennis Sandris; Greisen, Gorm.
In: Acta Paediatrica, Vol. 105, No. 9, 2016, p. 1074-1078.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - The half-life and exposure of cefuroxime varied in newborn infants after a Caesarean section
AU - Zachariassen, G.
AU - Hyldig, N.
AU - Joergensen, J.S.
AU - Nielsen, Dennis Sandris
AU - Greisen, Gorm
PY - 2016
Y1 - 2016
N2 - Aim: No information was available on how fast intravenous cefuroxime administered to pregnant women before a Caesarean section was cleared in newborn infants. This study investigated the drug's half-life and the exposure of healthy newborn infants after their mothers received the drug. Methods: Healthy mothers received a single dose of cefuroxime 15–60 minutes before skin incision. One blood sample was drawn from the umbilical cord, and two blood samples were drawn from the infant after delivery. Total plasma cefuroxime (μg/mL) was measured using high-pressure liquid chromatography. Results: Cefuroxime was given to 22 mothers, including two who had twins. The concentration of cefuroxime varied significantly among infants (p < 0.001), while the rate of decline did not (p = 0.24). The median cefuroxime half-life was 3.5 hours (range 2.9–5.5), which was approximately three times longer than in normal adults and seemed to clear within 24 hours. The median area under the concentration–time curve was 65.0 hour μg/mL (range 31.7–162.4). Conclusion: We found that the cefuroxime half-life after a Caesarean section varied among infants and was longer than in normal adults but cleared within 24 hours. Exposure to cefuroxime in newborn infants may influence the gut microbiota and should be investigated further.
AB - Aim: No information was available on how fast intravenous cefuroxime administered to pregnant women before a Caesarean section was cleared in newborn infants. This study investigated the drug's half-life and the exposure of healthy newborn infants after their mothers received the drug. Methods: Healthy mothers received a single dose of cefuroxime 15–60 minutes before skin incision. One blood sample was drawn from the umbilical cord, and two blood samples were drawn from the infant after delivery. Total plasma cefuroxime (μg/mL) was measured using high-pressure liquid chromatography. Results: Cefuroxime was given to 22 mothers, including two who had twins. The concentration of cefuroxime varied significantly among infants (p < 0.001), while the rate of decline did not (p = 0.24). The median cefuroxime half-life was 3.5 hours (range 2.9–5.5), which was approximately three times longer than in normal adults and seemed to clear within 24 hours. The median area under the concentration–time curve was 65.0 hour μg/mL (range 31.7–162.4). Conclusion: We found that the cefuroxime half-life after a Caesarean section varied among infants and was longer than in normal adults but cleared within 24 hours. Exposure to cefuroxime in newborn infants may influence the gut microbiota and should be investigated further.
KW - Caesarean section
KW - Cefuroxime
KW - Newborn infants
U2 - 10.1111/apa.13489
DO - 10.1111/apa.13489
M3 - Journal article
C2 - 27240549
AN - SCOPUS:84978756719
VL - 105
SP - 1074
EP - 1078
JO - Acta Paediatrica
JF - Acta Paediatrica
SN - 0803-5253
IS - 9
ER -
ID: 170476863