Microbial interactions, biofilms, hygiene and safety
Our research group is dedicated to advancing food safety and limiting microbial spoilage, thereby reducing food waste through innovative approaches. We aim to understand the organisms per se as well as the role of the microbial communities in persistence and evolution. Understanding the interactions between community members and how these interactions give rise to emergent properties is crucial for effectively managing complex communities and improve performance of bacteria.
The research spans from fundamental studies elucidating molecular mechanisms to the practical application of new preservation methods, including biopreservation, in industrial settings. We aim to develop a nuanced understanding of how various parameters and interactions influence microbial food quality and safety, translating this knowledge into improved practices for industrial food production.
Research Themes
Most bacteria live in structured biofilms capable of adhering to surfaces and enclosed in a matrix that can provide enhanced protection against environmental stress. Our research explores how bacteria in biofilm interact and develops, their structure, and how they can withstand adverse effects. We especially focus on multispecies biofilms interactions, as they have shown emergent properties compared to mono-species and contribute to e.g. increased resistance. We use advanced microscopy and molecular techniques to study their different stages, from the initial attachment to the mature form, to understand the genetic and physiological mechanisms that e.g. make them resistant to antimicrobial treatments. We aim to use this knowledge to develop new strategies to disrupt biofilm formation and improve the effectiveness of cleaning and disinfection agents. The results of our research have applications within a wide range of industries, including food production, where biofilms can cause both spoilage and foodborne outbreaks of pathogenic bacteria
Our research focuses on studying the dynamics and interactions within microbial communities in various environments. We aim to understand how they evolve, adapt, and interact within complex ecosystems, including their role in contamination, spoilage, and food safety. Additionally, we study the complex relationships within microbial communities, such as cooperation. We utilise these evolutionary insights to enhance resilience and production of beneficial communities. Through advanced analytical techniques and molecular studies, we aim to explore the genetic and physiological mechanisms that influence microbial behaviour and resilience. These insights are used to develop targeted interventions that influence biofilm formation, resilience, and pathogenicity. Furthermore, we also delve into inter-kingdom interactions by exploring the synergies between bacteria and microalgae, to exploit microalgae as an alternative protein source.
Our bioprotection research focuses on using natural microbial communities and antimicrobial agents in innovative ways. We are investigating and developing biobarrier technologies that rely on the competitive interactions among beneficial microorganisms to prevent the growth of spoilage or pathogenic organisms for use in food processing. We explore the efficacy of bacterial communities and their cumulative effects to ensure targeted control while minimizing environmental impact. Our sustainable approach aims to improve food safety across industries by promoting eco-friendly practices.
Promoting good hygiene practices is essential for preventing microbial contamination and ensuring product safety. Our research assesses the effectiveness of various cleaning and disinfection methods and technologies for eliminating microbial biofilms and communities from surfaces. We can identify and trace sources and pathways of microbial hazards and spoilage organisms in critical settings such as food production facilities. We aim to understand and quantify the variations in stress tolerance and cross-resistance of individual pathogenic organisms towards different preservation strategies, including new technologies, in order to ensure safety and help define critical limits in industrial settings.
To analyse complex microbial communities to single cell level we create targeted interventions, harnessing synergy by combining cutting-edge multidisciplinary technology and methodology. We use advanced confocal laser scanning microscopy, high-throughput sequencing, advanced molecular techniques, and computational tools to understand microbial ecology and emergent behaviour in microbial communities. This interdisciplinary approach helps us improve the quality and safety of foods and improve bacteria performance.
If you would like to learn more about our research initiatives or explore collaboration opportunities, please do not hesitate to contact us. We would be happy to provide you with further information and discuss potential partnerships.
Contact
Henriette Lyng Røder
Tenure Track Assistant Professor
h.lyng.roeder@food.ku.dk
Henrik Siegumfeldt
Associate Professor
siegum@food.ku.dk
Susanne Knøchel
Professor
skn@food.ku.dk