Theoretical analysis of protein organization in lipid membranes

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  • Tamir Gil
  • John Hjort Ipsen
  • Mouritsen, Ole G.
  • Mads C. Sabra
  • Maria M. Sperotto
  • Martin J. Zuckermann

The fundamental physical principles of the lateral organization of trans-membrane proteins and peptides as well as peripheral membrane proteins and enzymes are considered from the point of view of the lipid-bilayer membrane, its structure, dynamics, and cooperative phenomena. Based on a variety of theoretical considerations and model calculations, the nature of lipid-protein interactions is considered both for a single protein and an assembly of proteins that can lead to aggregation and protein crystallization in the plane of the membrane. Phenomena discussed include lipid sorting and selectivity at protein surfaces, protein-lipid phase equilibria, lipid-mediated protein-protein interactions, wetting and capillary condensation as means of protein organization, mechanisms of two-dimensional protein crystallization, as well as non-equilibrium organization of active proteins in membranes. The theoretical findings are compared with a variety of experimental data. Copyright (C) 1998 Elsevier Science B.V.

Original languageEnglish
JournalBiochimica et Biophysica Acta - Reviews on Biomembranes
Issue number3
Pages (from-to)245-266
Number of pages22
Publication statusPublished - 10 Nov 1998

    Research areas

  • Lateral organization, Lipid bilayer, Lipid-protein interaction, Membrane deformation, Membrane protein, Phase equilibrium, Protein aggregation, Protein crystallization, Protein-protein interaction, Wetting

ID: 236886566