TY - JOUR

T1 - Theoretical analysis of protein organization in lipid membranes

AU - Gil, Tamir

AU - Ipsen, John Hjort

AU - Mouritsen, Ole G.

AU - Sabra, Mads C.

AU - Sperotto, Maria M.

AU - Zuckermann, Martin J.

PY - 1998/11/10

Y1 - 1998/11/10

N2 - The fundamental physical principles of the lateral organization of trans-membrane proteins and peptides as well as peripheral membrane proteins and enzymes are considered from the point of view of the lipid-bilayer membrane, its structure, dynamics, and cooperative phenomena. Based on a variety of theoretical considerations and model calculations, the nature of lipid-protein interactions is considered both for a single protein and an assembly of proteins that can lead to aggregation and protein crystallization in the plane of the membrane. Phenomena discussed include lipid sorting and selectivity at protein surfaces, protein-lipid phase equilibria, lipid-mediated protein-protein interactions, wetting and capillary condensation as means of protein organization, mechanisms of two-dimensional protein crystallization, as well as non-equilibrium organization of active proteins in membranes. The theoretical findings are compared with a variety of experimental data. Copyright (C) 1998 Elsevier Science B.V.

AB - The fundamental physical principles of the lateral organization of trans-membrane proteins and peptides as well as peripheral membrane proteins and enzymes are considered from the point of view of the lipid-bilayer membrane, its structure, dynamics, and cooperative phenomena. Based on a variety of theoretical considerations and model calculations, the nature of lipid-protein interactions is considered both for a single protein and an assembly of proteins that can lead to aggregation and protein crystallization in the plane of the membrane. Phenomena discussed include lipid sorting and selectivity at protein surfaces, protein-lipid phase equilibria, lipid-mediated protein-protein interactions, wetting and capillary condensation as means of protein organization, mechanisms of two-dimensional protein crystallization, as well as non-equilibrium organization of active proteins in membranes. The theoretical findings are compared with a variety of experimental data. Copyright (C) 1998 Elsevier Science B.V.

KW - Lateral organization

KW - Lipid bilayer

KW - Lipid-protein interaction

KW - Membrane deformation

KW - Membrane protein

KW - Phase equilibrium

KW - Protein aggregation

KW - Protein crystallization

KW - Protein-protein interaction

KW - Wetting

UR - http://www.scopus.com/inward/record.url?scp=0031740471&partnerID=8YFLogxK

U2 - 10.1016/S0304-4157(98)00022-7

DO - 10.1016/S0304-4157(98)00022-7

M3 - Review

C2 - 9804966

AN - SCOPUS:0031740471

VL - 1376

SP - 245

EP - 266

JO - Biochimica et Biophysica Acta - Reviews on Biomembranes

JF - Biochimica et Biophysica Acta - Reviews on Biomembranes

SN - 0304-4157

IS - 3

ER -