Synthesis of enantiopure 3-substituted morpholines

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Synthesis of enantiopure 3-substituted morpholines. / Bornholdt, Jan; Felding, Jakob; Kristensen, Jesper Langgaard.

In: Journal of Organic Chemistry, Vol. 75, No. 21, 2010, p. 7454-7457.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Bornholdt, J, Felding, J & Kristensen, JL 2010, 'Synthesis of enantiopure 3-substituted morpholines', Journal of Organic Chemistry, vol. 75, no. 21, pp. 7454-7457. https://doi.org/10.1021/jo101339g

APA

Bornholdt, J., Felding, J., & Kristensen, J. L. (2010). Synthesis of enantiopure 3-substituted morpholines. Journal of Organic Chemistry, 75(21), 7454-7457. https://doi.org/10.1021/jo101339g

Vancouver

Bornholdt J, Felding J, Kristensen JL. Synthesis of enantiopure 3-substituted morpholines. Journal of Organic Chemistry. 2010;75(21):7454-7457. https://doi.org/10.1021/jo101339g

Author

Bornholdt, Jan ; Felding, Jakob ; Kristensen, Jesper Langgaard. / Synthesis of enantiopure 3-substituted morpholines. In: Journal of Organic Chemistry. 2010 ; Vol. 75, No. 21. pp. 7454-7457.

Bibtex

@article{552e83f0e34311dfb6d2000ea68e967b,
title = "Synthesis of enantiopure 3-substituted morpholines",
abstract = "Enantiopure 3-substituted morpholines were assembled through ring-opening of a N-2-benzothiazolesulfonyl (Bts) activated aziridine with organocuprates followed by a ring annulation reaction with a vinylsulfonium salt under microwave conditions. Deprotection of the N-Bts group proceeds under very mild conditions with 2-mercaptoacetic acid and LiOH at rt.",
keywords = "Former Faculty of Pharmaceutical Sciences",
author = "Jan Bornholdt and Jakob Felding and Kristensen, {Jesper Langgaard}",
year = "2010",
doi = "10.1021/jo101339g",
language = "English",
volume = "75",
pages = "7454--7457",
journal = "Journal of Organic Chemistry",
issn = "0022-3263",
publisher = "American Chemical Society",
number = "21",

}

RIS

TY - JOUR

T1 - Synthesis of enantiopure 3-substituted morpholines

AU - Bornholdt, Jan

AU - Felding, Jakob

AU - Kristensen, Jesper Langgaard

PY - 2010

Y1 - 2010

N2 - Enantiopure 3-substituted morpholines were assembled through ring-opening of a N-2-benzothiazolesulfonyl (Bts) activated aziridine with organocuprates followed by a ring annulation reaction with a vinylsulfonium salt under microwave conditions. Deprotection of the N-Bts group proceeds under very mild conditions with 2-mercaptoacetic acid and LiOH at rt.

AB - Enantiopure 3-substituted morpholines were assembled through ring-opening of a N-2-benzothiazolesulfonyl (Bts) activated aziridine with organocuprates followed by a ring annulation reaction with a vinylsulfonium salt under microwave conditions. Deprotection of the N-Bts group proceeds under very mild conditions with 2-mercaptoacetic acid and LiOH at rt.

KW - Former Faculty of Pharmaceutical Sciences

U2 - 10.1021/jo101339g

DO - 10.1021/jo101339g

M3 - Journal article

C2 - 20879782

VL - 75

SP - 7454

EP - 7457

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

SN - 0022-3263

IS - 21

ER -

ID: 22796243