Synthesis of enantiopure 3-substituted morpholines

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Enantiopure 3-substituted morpholines were assembled through ring-opening of a N-2-benzothiazolesulfonyl (Bts) activated aziridine with organocuprates followed by a ring annulation reaction with a vinylsulfonium salt under microwave conditions. Deprotection of the N-Bts group proceeds under very mild conditions with 2-mercaptoacetic acid and LiOH at rt.
Original languageEnglish
JournalJournal of Organic Chemistry
Issue number21
Pages (from-to)7454-7457
Publication statusPublished - 2010

ID: 22796243