Quantification of the enantiomeric excess of two APIs by means of near infrared spectroscopy and chemometrics

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Lorenzo Rigoni, Sara Venti, Marta Bevilacqua, Remo Bucci, Andrea D. Magrì, Antonio L. Magrì, Federico Marini

A method for the quantification of the enantiomeric excess of two pharmaceutical active ingredients (ibuprofen and epinephrine) in the solid state based on coupling near infrared spectroscopy and chemometrics is proposed. In the case of ibuprofen, in the absence of excipients, the method resulted in an accurate prediction of the enantiopurity of the validation samples (RMSEP
Original languageEnglish
JournalChemometrics and Intelligent Laboratory Systems
Volume133
Pages (from-to)149 - 156
ISSN0169-7439
DOIs
Publication statusPublished - 2014
Externally publishedYes

    Research areas

  • Enantiomeric excess, Near infrared spectroscopy (NIR), Ibuprofen, Epinephrine, Partial least squares (PLS) regression

ID: 228372740