Quantification of the enantiomeric excess of two APIs by means of near infrared spectroscopy and chemometrics
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Quantification of the enantiomeric excess of two APIs by means of near infrared spectroscopy and chemometrics. / Rigoni, Lorenzo; Venti, Sara; Bevilacqua, Marta; Bucci, Remo; Magrì, Andrea D.; Magrì, Antonio L.; Marini, Federico.
In: Chemometrics and Intelligent Laboratory Systems, Vol. 133, 2014, p. 149 - 156.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Quantification of the enantiomeric excess of two APIs by means of near infrared spectroscopy and chemometrics
AU - Rigoni, Lorenzo
AU - Venti, Sara
AU - Bevilacqua, Marta
AU - Bucci, Remo
AU - Magrì, Andrea D.
AU - Magrì, Antonio L.
AU - Marini, Federico
PY - 2014
Y1 - 2014
N2 - A method for the quantification of the enantiomeric excess of two pharmaceutical active ingredients (ibuprofen and epinephrine) in the solid state based on coupling near infrared spectroscopy and chemometrics is proposed. In the case of ibuprofen, in the absence of excipients, the method resulted in an accurate prediction of the enantiopurity of the validation samples (RMSEP
AB - A method for the quantification of the enantiomeric excess of two pharmaceutical active ingredients (ibuprofen and epinephrine) in the solid state based on coupling near infrared spectroscopy and chemometrics is proposed. In the case of ibuprofen, in the absence of excipients, the method resulted in an accurate prediction of the enantiopurity of the validation samples (RMSEP
KW - Enantiomeric excess
KW - Near infrared spectroscopy (NIR)
KW - Ibuprofen
KW - Epinephrine
KW - Partial least squares (PLS) regression
U2 - 10.1016/j.chemolab.2014.02.004
DO - 10.1016/j.chemolab.2014.02.004
M3 - Journal article
VL - 133
SP - 149
EP - 156
JO - Chemometrics and Intelligent Laboratory Systems
JF - Chemometrics and Intelligent Laboratory Systems
SN - 0169-7439
ER -
ID: 228372740