Quantification of the enantiomeric excess of two APIs by means of near infrared spectroscopy and chemometrics

Research output: Contribution to journalJournal articleResearchpeer-review

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Quantification of the enantiomeric excess of two APIs by means of near infrared spectroscopy and chemometrics. / Rigoni, Lorenzo; Venti, Sara; Bevilacqua, Marta; Bucci, Remo; Magrì, Andrea D.; Magrì, Antonio L.; Marini, Federico.

In: Chemometrics and Intelligent Laboratory Systems, Vol. 133, 2014, p. 149 - 156.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Rigoni, L, Venti, S, Bevilacqua, M, Bucci, R, Magrì, AD, Magrì, AL & Marini, F 2014, 'Quantification of the enantiomeric excess of two APIs by means of near infrared spectroscopy and chemometrics', Chemometrics and Intelligent Laboratory Systems, vol. 133, pp. 149 - 156. https://doi.org/10.1016/j.chemolab.2014.02.004

APA

Rigoni, L., Venti, S., Bevilacqua, M., Bucci, R., Magrì, A. D., Magrì, A. L., & Marini, F. (2014). Quantification of the enantiomeric excess of two APIs by means of near infrared spectroscopy and chemometrics. Chemometrics and Intelligent Laboratory Systems, 133, 149 - 156. https://doi.org/10.1016/j.chemolab.2014.02.004

Vancouver

Rigoni L, Venti S, Bevilacqua M, Bucci R, Magrì AD, Magrì AL et al. Quantification of the enantiomeric excess of two APIs by means of near infrared spectroscopy and chemometrics. Chemometrics and Intelligent Laboratory Systems. 2014;133:149 - 156. https://doi.org/10.1016/j.chemolab.2014.02.004

Author

Rigoni, Lorenzo ; Venti, Sara ; Bevilacqua, Marta ; Bucci, Remo ; Magrì, Andrea D. ; Magrì, Antonio L. ; Marini, Federico. / Quantification of the enantiomeric excess of two APIs by means of near infrared spectroscopy and chemometrics. In: Chemometrics and Intelligent Laboratory Systems. 2014 ; Vol. 133. pp. 149 - 156.

Bibtex

@article{0dd9dc57702a46f390c99bd5f5426e56,
title = "Quantification of the enantiomeric excess of two APIs by means of near infrared spectroscopy and chemometrics",
abstract = "A method for the quantification of the enantiomeric excess of two pharmaceutical active ingredients (ibuprofen and epinephrine) in the solid state based on coupling near infrared spectroscopy and chemometrics is proposed. In the case of ibuprofen, in the absence of excipients, the method resulted in an accurate prediction of the enantiopurity of the validation samples (RMSEP",
keywords = "Enantiomeric excess, Near infrared spectroscopy (NIR), Ibuprofen, Epinephrine, Partial least squares (PLS) regression",
author = "Lorenzo Rigoni and Sara Venti and Marta Bevilacqua and Remo Bucci and Magr{\`i}, {Andrea D.} and Magr{\`i}, {Antonio L.} and Federico Marini",
year = "2014",
doi = "10.1016/j.chemolab.2014.02.004",
language = "English",
volume = "133",
pages = "149 -- 156",
journal = "Chemometrics and Intelligent Laboratory Systems",
issn = "0169-7439",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Quantification of the enantiomeric excess of two APIs by means of near infrared spectroscopy and chemometrics

AU - Rigoni, Lorenzo

AU - Venti, Sara

AU - Bevilacqua, Marta

AU - Bucci, Remo

AU - Magrì, Andrea D.

AU - Magrì, Antonio L.

AU - Marini, Federico

PY - 2014

Y1 - 2014

N2 - A method for the quantification of the enantiomeric excess of two pharmaceutical active ingredients (ibuprofen and epinephrine) in the solid state based on coupling near infrared spectroscopy and chemometrics is proposed. In the case of ibuprofen, in the absence of excipients, the method resulted in an accurate prediction of the enantiopurity of the validation samples (RMSEP

AB - A method for the quantification of the enantiomeric excess of two pharmaceutical active ingredients (ibuprofen and epinephrine) in the solid state based on coupling near infrared spectroscopy and chemometrics is proposed. In the case of ibuprofen, in the absence of excipients, the method resulted in an accurate prediction of the enantiopurity of the validation samples (RMSEP

KW - Enantiomeric excess

KW - Near infrared spectroscopy (NIR)

KW - Ibuprofen

KW - Epinephrine

KW - Partial least squares (PLS) regression

U2 - 10.1016/j.chemolab.2014.02.004

DO - 10.1016/j.chemolab.2014.02.004

M3 - Journal article

VL - 133

SP - 149

EP - 156

JO - Chemometrics and Intelligent Laboratory Systems

JF - Chemometrics and Intelligent Laboratory Systems

SN - 0169-7439

ER -

ID: 228372740