Protein intake and the incidence of pre-diabetes and diabetes in 4 population-based studies: the PREVIEW project
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Protein intake and the incidence of pre-diabetes and diabetes in 4 population-based studies : the PREVIEW project. / Sluik, Diewertje; Brouwer-Brolsma, Elske M; Berendsen, Agnes A M; Mikkilä, Vera; Poppitt, Sally D; Silvestre, Marta P; Tremblay, Angelo; Pérusse, Louis; Bouchard, Claude; Raben, Anne; Feskens, Edith J M.
In: American Journal of Clinical Nutrition, Vol. 109, No. 5, 2019, p. 1310-1318.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Protein intake and the incidence of pre-diabetes and diabetes in 4 population-based studies
T2 - the PREVIEW project
AU - Sluik, Diewertje
AU - Brouwer-Brolsma, Elske M
AU - Berendsen, Agnes A M
AU - Mikkilä, Vera
AU - Poppitt, Sally D
AU - Silvestre, Marta P
AU - Tremblay, Angelo
AU - Pérusse, Louis
AU - Bouchard, Claude
AU - Raben, Anne
AU - Feskens, Edith J M
N1 - CURIS 2019 NEXS 154 Copyright © American Society for Nutrition 2019.
PY - 2019
Y1 - 2019
N2 - Background: Data on the relationship between protein intake and the risk of type 2 diabetes are conflicting.Objective: We studied prospective associations between the intake of total, plant-based, and animal protein and the risk of pre-diabetes and diabetes in 4 population-based studies included in the PREVIEW project.Methods: Analyses were conducted with the use of data from 3 European cohorts and 1 Canadian cohort, including 78,851 participants. Protein intake was assessed through the use of harmonized data from food-frequency questionnaires or 3-d dietary records. Cohort-specific incidence ratios (IRs) were estimated for pre-diabetes and diabetes, adjusting for general characteristics, lifestyle and dietary factors, disease history, and body mass index (BMI) and waist circumference; results were pooled based on a random-effects meta-analysis.Results: Higher total protein intake (g · kg-1 · d-1) was associated with lower incidences of pre-diabetes and diabetes (pooled IRs: 0.84; 95% CI: 0.82, 0.87 and 0.49; 95% CI: 0.28, 0.83, respectively); plant-based protein intake was the main determinant (pooled IRs: 0.83; 95% CI: 0.81, 0.86 and 0.53; 95% CI: 0.36, 0.76, respectively). Substituting 2 energy percentage (E%) protein at the expense of carbohydrates revealed increased risks of pre-diabetes and diabetes (pooled IRs: 1.04; 95% CI: 1.01, 1.07 and 1.09; 95% CI: 1.01, 1.18, respectively). Except for the associations between intakes of total protein and plant-based protein (g · kg-1 · d-1) and diabetes, all other associations became nonsignificant after adjustment for BMI and waist circumference.Conclusions: Higher protein intake (g · kg-1 · d-1) was associated with a lower risk of pre-diabetes and diabetes. Associations were substantially attenuated after adjustments for BMI and waist circumference, which demonstrates a crucial role for adiposity and may account for previous conflicting findings. This study was registered at ISRCTN as ISRCTN31174892.
AB - Background: Data on the relationship between protein intake and the risk of type 2 diabetes are conflicting.Objective: We studied prospective associations between the intake of total, plant-based, and animal protein and the risk of pre-diabetes and diabetes in 4 population-based studies included in the PREVIEW project.Methods: Analyses were conducted with the use of data from 3 European cohorts and 1 Canadian cohort, including 78,851 participants. Protein intake was assessed through the use of harmonized data from food-frequency questionnaires or 3-d dietary records. Cohort-specific incidence ratios (IRs) were estimated for pre-diabetes and diabetes, adjusting for general characteristics, lifestyle and dietary factors, disease history, and body mass index (BMI) and waist circumference; results were pooled based on a random-effects meta-analysis.Results: Higher total protein intake (g · kg-1 · d-1) was associated with lower incidences of pre-diabetes and diabetes (pooled IRs: 0.84; 95% CI: 0.82, 0.87 and 0.49; 95% CI: 0.28, 0.83, respectively); plant-based protein intake was the main determinant (pooled IRs: 0.83; 95% CI: 0.81, 0.86 and 0.53; 95% CI: 0.36, 0.76, respectively). Substituting 2 energy percentage (E%) protein at the expense of carbohydrates revealed increased risks of pre-diabetes and diabetes (pooled IRs: 1.04; 95% CI: 1.01, 1.07 and 1.09; 95% CI: 1.01, 1.18, respectively). Except for the associations between intakes of total protein and plant-based protein (g · kg-1 · d-1) and diabetes, all other associations became nonsignificant after adjustment for BMI and waist circumference.Conclusions: Higher protein intake (g · kg-1 · d-1) was associated with a lower risk of pre-diabetes and diabetes. Associations were substantially attenuated after adjustments for BMI and waist circumference, which demonstrates a crucial role for adiposity and may account for previous conflicting findings. This study was registered at ISRCTN as ISRCTN31174892.
KW - Faculty of Science
KW - Diabetes
KW - Impaired glucose metabolism
KW - Protein intake
KW - Observational studies
KW - Epidemiology
U2 - 10.1093/ajcn/nqy388
DO - 10.1093/ajcn/nqy388
M3 - Journal article
C2 - 31051510
VL - 109
SP - 1310
EP - 1318
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
SN - 0002-9165
IS - 5
ER -
ID: 217550727