Propionylated high-amylose maize starch alleviates obesity by modulating gut microbiota in high-fat diet-fed mice

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  • Xie, Zhuqing
  • Minghua Yao
  • Josué L. Castro-Mejía
  • Ming Ma
  • Yuyan Zhu
  • Xiong Fu
  • Qiang Huang
  • Bin Zhang

Obesity threatens human health worldwide, and mounting findings have found that gut microbiota (GM) changes induced by diet intervention influence its development. This study aims to investigate the anti-obesity effects and GM changes of propionylated high-amylose maize starch (PS) in C57BL/6J mice fed with high-fat diet (HFD). In our results, PS decreased the body weight of HFD-fed mice after 8 weeks and regulated the glucose stability and insulin resistance. High-amylose maize starch (HAMS) and PS regulated the serum lipid levels and inflammatory response. Moreover, PS yielded more propionate relative to HAMS, proving that introduced propionyl groups could be released in the colon. 16S rRNA results showed that PS altered GM with the increase of bacteria (S24-7 and Ruminococcus) and decrease of harmful genera, which is linked to the anti-obesity effect. Our results provide a reference for the design of functional dietary fibers inducing high propionate production and GM modulation.

Original languageEnglish
Article number105447
JournalJournal of Functional Foods
Number of pages10
Publication statusPublished - 2023

Bibliographical note

Publisher Copyright:
© 2023 The Author(s)

    Research areas

  • Gut microbiota, High-fat diet, Propionate, Propionylated high-amylose maize starch

ID: 339851349