BioSyn - Bioactive components from by-products of food processing used in a synbiotic approach for improving human health and well-being

Project period: 2014 – 2017

The main objective of the project is to improve sustainability of food processing by delivering the novel bioactive components from food by-products and waste that alone or in combination with already acknowledged probiotic bacteria can be used to improve human health and wellbeing.

By-products and waste generated in fruits and vegetables processing, such as production of juices, pectin, starches, etc., have a significant nutritive value, containing fiber and bioactive substances. The project aims to improve utilization of the by-products and recovery of bioactive components by delivery of functional food formulations for human consumption. The by-products and waste of concern are peel, pulp and pectin from tropical fruits, besides, fiber and starches from potato processing. The by-products will be converted into multifunctional synbiotic carriers for colon-specific delivery of probiotic lactobacilli and bifidobacteria. Prebiotic potential of the food by-products, such as supporting growth of probiotics, their adhesion to intestinal cells and host immunomodulation, will be investigated using in vitro mammalian cell models. The hypothesis that prebiotics and synbiotics can beneficially modulate the gut microbiota will be tested by gastrointestinal models using microbiota profiling techniques and the next generation DNA sequencing. Microbiota studies will focus primarily on the metabolic diseases. The bioactive carbohydrate epitopes related to prebiotic action and their dynamic in intestinal environment will be determined by chromatography and carbohydrate microarrays. The multivariate statistical models will be developed to link the bioactive structures in the synbiotic products with their functionality and prebiotic capacity for prediction of health benefits. Finally, BioSyn will develop and produce a synbiotic dietary formulation based on the food by-products. The outcome of BioSyn will include a new knowledge of combined potential of synbiotic ingredients for improvement of human health and the tools to generate novel synbiotic formulations from the food by-products.






Funded by:

Picture of Innovation Fund Denmark's logo

Biosyn has received a four year funding from The Danish Council for Strategic Research (now Innovation Fund Denmark)

Funding: DKK 3,354,358
Project: BioSyn - Bioactive components from by-products of food processing used in a synbiotic approach for improving human health and well-being
Period:  1 January 2014 – 31 December 2017

BioSyn logo


Picture of Professor Lene JespersenLene Jespersen
Microbiology and Fermentation

Academic employee Nadja LarsenNadja Larsen
Academic Employee
Microbiology and Fermentation

Senior Adviser Henriette HansenHenriette Hansen 
Senior Adviser 
Administrative Coordinator
Food Administration