High-dose vitamin D during pregnancy and pathway gene polymorphisms in prevention of offspring persistent wheeze

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

High-dose vitamin D during pregnancy and pathway gene polymorphisms in prevention of offspring persistent wheeze. / Brustad, Nicklas; Greve, Jens H; Mirzakhani, Hooman; Pedersen, Casper-Emil T.; Eliasen, Anders U; Stokholm, Jakob; Lasky-Su, Jessica; Bønnelykke, Klaus; Litonjua, Augusto A; Weiss, Scott T; Bisgaard, Hans; Chawes, Bo L.

In: Pediatric Allergy and Immunology, Vol. 32, No. 4, 2021, p. 679-689.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Brustad, N, Greve, JH, Mirzakhani, H, Pedersen, C-ET, Eliasen, AU, Stokholm, J, Lasky-Su, J, Bønnelykke, K, Litonjua, AA, Weiss, ST, Bisgaard, H & Chawes, BL 2021, 'High-dose vitamin D during pregnancy and pathway gene polymorphisms in prevention of offspring persistent wheeze', Pediatric Allergy and Immunology, vol. 32, no. 4, pp. 679-689. https://doi.org/10.1111/pai.13453

APA

Brustad, N., Greve, J. H., Mirzakhani, H., Pedersen, C-E. T., Eliasen, A. U., Stokholm, J., Lasky-Su, J., Bønnelykke, K., Litonjua, A. A., Weiss, S. T., Bisgaard, H., & Chawes, B. L. (2021). High-dose vitamin D during pregnancy and pathway gene polymorphisms in prevention of offspring persistent wheeze. Pediatric Allergy and Immunology, 32(4), 679-689. https://doi.org/10.1111/pai.13453

Vancouver

Brustad N, Greve JH, Mirzakhani H, Pedersen C-ET, Eliasen AU, Stokholm J et al. High-dose vitamin D during pregnancy and pathway gene polymorphisms in prevention of offspring persistent wheeze. Pediatric Allergy and Immunology. 2021;32(4):679-689. https://doi.org/10.1111/pai.13453

Author

Brustad, Nicklas ; Greve, Jens H ; Mirzakhani, Hooman ; Pedersen, Casper-Emil T. ; Eliasen, Anders U ; Stokholm, Jakob ; Lasky-Su, Jessica ; Bønnelykke, Klaus ; Litonjua, Augusto A ; Weiss, Scott T ; Bisgaard, Hans ; Chawes, Bo L. / High-dose vitamin D during pregnancy and pathway gene polymorphisms in prevention of offspring persistent wheeze. In: Pediatric Allergy and Immunology. 2021 ; Vol. 32, No. 4. pp. 679-689.

Bibtex

@article{967a1c7a631444468ec04758ec90f9c6,

title = "High-dose vitamin D during pregnancy and pathway gene polymorphisms in prevention of offspring persistent wheeze",

abstract = "BACKGROUND: Randomized controlled trials (RCTs) suggest a protective effect of high-dose vitamin D supplementation in pregnancy on offspring risk of persistent wheeze, but only in some individuals, which might be explained by variations in vitamin D pathway genes. This study aimed to investigate the effect of vitamin D supplementation by maternal and offspring vitamin D receptor (VDR) genotype and GC genotype, encoding vitamin D binding protein (VDBP), in two RCTs.METHODS: In the Copenhagen Prospective Studies on Asthma in Childhood (COPSAC2010 ) RCT, we analyzed the effect of high-dose vitamin D during pregnancy on the risk of persistent wheeze age 0-3 years by variants in single nucleotide polymorphisms (SNPs) in VDR (rs1544410, rs2228570, rs7975128, rs7975232) and GC (rs4588, rs7041). Replication was sought in the Vitamin D Antenatal Asthma Reduction Trial (VDAART).RESULTS: In COPSAC2010 , VDR SNP rs1544410 influenced the effect of high-dose vitamin D: maternal Pinteraction = .049 and child Pinteraction = .001, with the largest effect in offspring from mothers with TT genotype: hazard ratio (95% CI), 0.26 (0.10-0.68), P = .006, and no effect among CT or CC genotypes: 0.85 (0.48-1.51), P = .58 and 0.94 (0.47-1.89), P = .87, respectively. However, these findings were not replicated in VDAART. There was no significant effect modification from maternal or offspring GC genotype in either COPSAC2010 or VDAART: all Pinteraction ≥ .17.CONCLUSIONS: We found that the effect of high-dose vitamin D supplementation during pregnancy on offspring risk of persistent wheeze was significantly influenced by VDR genotype in the COPSAC2010 RCT, but not VDAART, which may be due to population differences.",

author = "Nicklas Brustad and Greve, {Jens H} and Hooman Mirzakhani and Pedersen, {Casper-Emil T.} and Eliasen, {Anders U} and Jakob Stokholm and Jessica Lasky-Su and Klaus B{\o}nnelykke and Litonjua, {Augusto A} and Weiss, {Scott T} and Hans Bisgaard and Chawes, {Bo L}",

note = "{\textcopyright} 2021 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.",

year = "2021",

doi = "10.1111/pai.13453",

language = "English",

volume = "32",

pages = "679--689",

journal = "Pediatric Allergy and Immunology, Supplement",

issn = "0906-5784",

publisher = "Wiley-Blackwell",

number = "4",

}

RIS

TY - JOUR

T1 - High-dose vitamin D during pregnancy and pathway gene polymorphisms in prevention of offspring persistent wheeze

AU - Brustad, Nicklas

AU - Greve, Jens H

AU - Mirzakhani, Hooman

AU - Pedersen, Casper-Emil T.

AU - Eliasen, Anders U

AU - Stokholm, Jakob

AU - Lasky-Su, Jessica

AU - Bønnelykke, Klaus

AU - Litonjua, Augusto A

AU - Weiss, Scott T

AU - Bisgaard, Hans

AU - Chawes, Bo L

PY - 2021

Y1 - 2021

N2 - BACKGROUND: Randomized controlled trials (RCTs) suggest a protective effect of high-dose vitamin D supplementation in pregnancy on offspring risk of persistent wheeze, but only in some individuals, which might be explained by variations in vitamin D pathway genes. This study aimed to investigate the effect of vitamin D supplementation by maternal and offspring vitamin D receptor (VDR) genotype and GC genotype, encoding vitamin D binding protein (VDBP), in two RCTs.METHODS: In the Copenhagen Prospective Studies on Asthma in Childhood (COPSAC2010 ) RCT, we analyzed the effect of high-dose vitamin D during pregnancy on the risk of persistent wheeze age 0-3 years by variants in single nucleotide polymorphisms (SNPs) in VDR (rs1544410, rs2228570, rs7975128, rs7975232) and GC (rs4588, rs7041). Replication was sought in the Vitamin D Antenatal Asthma Reduction Trial (VDAART).RESULTS: In COPSAC2010 , VDR SNP rs1544410 influenced the effect of high-dose vitamin D: maternal Pinteraction = .049 and child Pinteraction = .001, with the largest effect in offspring from mothers with TT genotype: hazard ratio (95% CI), 0.26 (0.10-0.68), P = .006, and no effect among CT or CC genotypes: 0.85 (0.48-1.51), P = .58 and 0.94 (0.47-1.89), P = .87, respectively. However, these findings were not replicated in VDAART. There was no significant effect modification from maternal or offspring GC genotype in either COPSAC2010 or VDAART: all Pinteraction ≥ .17.CONCLUSIONS: We found that the effect of high-dose vitamin D supplementation during pregnancy on offspring risk of persistent wheeze was significantly influenced by VDR genotype in the COPSAC2010 RCT, but not VDAART, which may be due to population differences.

AB - BACKGROUND: Randomized controlled trials (RCTs) suggest a protective effect of high-dose vitamin D supplementation in pregnancy on offspring risk of persistent wheeze, but only in some individuals, which might be explained by variations in vitamin D pathway genes. This study aimed to investigate the effect of vitamin D supplementation by maternal and offspring vitamin D receptor (VDR) genotype and GC genotype, encoding vitamin D binding protein (VDBP), in two RCTs.METHODS: In the Copenhagen Prospective Studies on Asthma in Childhood (COPSAC2010 ) RCT, we analyzed the effect of high-dose vitamin D during pregnancy on the risk of persistent wheeze age 0-3 years by variants in single nucleotide polymorphisms (SNPs) in VDR (rs1544410, rs2228570, rs7975128, rs7975232) and GC (rs4588, rs7041). Replication was sought in the Vitamin D Antenatal Asthma Reduction Trial (VDAART).RESULTS: In COPSAC2010 , VDR SNP rs1544410 influenced the effect of high-dose vitamin D: maternal Pinteraction = .049 and child Pinteraction = .001, with the largest effect in offspring from mothers with TT genotype: hazard ratio (95% CI), 0.26 (0.10-0.68), P = .006, and no effect among CT or CC genotypes: 0.85 (0.48-1.51), P = .58 and 0.94 (0.47-1.89), P = .87, respectively. However, these findings were not replicated in VDAART. There was no significant effect modification from maternal or offspring GC genotype in either COPSAC2010 or VDAART: all Pinteraction ≥ .17.CONCLUSIONS: We found that the effect of high-dose vitamin D supplementation during pregnancy on offspring risk of persistent wheeze was significantly influenced by VDR genotype in the COPSAC2010 RCT, but not VDAART, which may be due to population differences.

U2 - 10.1111/pai.13453

DO - 10.1111/pai.13453

M3 - Journal article

C2 - 33453076

VL - 32

SP - 679

EP - 689

JO - Pediatric Allergy and Immunology, Supplement

JF - Pediatric Allergy and Immunology, Supplement

SN - 0906-5784

IS - 4

ER -

ID: 259830108

Department of Food Science