Small-scale structure in fluid cholesterol-lipid bilayers

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Small-scale structure in fluid cholesterol-lipid bilayers. / Rheinstädter, Maikel C.; Mouritsen, Ole G.

In: Current Opinion in Colloid and Interface Science, Vol. 18, No. 5, 2013, p. 440-447.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Rheinstädter, MC & Mouritsen, OG 2013, 'Small-scale structure in fluid cholesterol-lipid bilayers', Current Opinion in Colloid and Interface Science, vol. 18, no. 5, pp. 440-447. https://doi.org/10.1016/j.cocis.2013.07.001

APA

Rheinstädter, M. C., & Mouritsen, O. G. (2013). Small-scale structure in fluid cholesterol-lipid bilayers. Current Opinion in Colloid and Interface Science, 18(5), 440-447. https://doi.org/10.1016/j.cocis.2013.07.001

Vancouver

Rheinstädter MC, Mouritsen OG. Small-scale structure in fluid cholesterol-lipid bilayers. Current Opinion in Colloid and Interface Science. 2013;18(5):440-447. https://doi.org/10.1016/j.cocis.2013.07.001

Author

Rheinstädter, Maikel C. ; Mouritsen, Ole G. / Small-scale structure in fluid cholesterol-lipid bilayers. In: Current Opinion in Colloid and Interface Science. 2013 ; Vol. 18, No. 5. pp. 440-447.

Bibtex

@article{3a24a939926b4bdeaced312e083cfcc5,
title = "Small-scale structure in fluid cholesterol-lipid bilayers",
abstract = "Cholesterol is the single most abundant molecule in animal plasma membranes, in the range of 20-30. mol%, where it is known to modulate the lipid-bilayer component of the membrane and lead to increased mechanical stability, lower permeability, larger thickness, and a distinct lateral organization. The phase equilibria of membranes with cholesterol and the associated large- and small-scale structure have turned out to be a particularly elusive problem. With the proposal that lipid domains and so-called 'rafts', characterized by high local levels of cholesterol in a liquid-ordered phase, are important for a wide range of cellular functions, an understanding and a quantitative assessment of the nature of these cholesterol-induced structures and their types of ordering have become urgent. Recent progress in neutron diffraction studies of lipid-cholesterol model membranes has now revealed details of the lateral ordering, and combined with earlier molecular model studies a picture emerges of the membrane as a locally structured liquid with small ordered 'domains' of a highly dynamic nature.",
keywords = "Cholesterol, Computer simulation, Correlation function, Lipid bilayer, Neutron scattering, Raft, Small-scale structure",
author = "Rheinst{\"a}dter, {Maikel C.} and Mouritsen, {Ole G.}",
year = "2013",
doi = "10.1016/j.cocis.2013.07.001",
language = "English",
volume = "18",
pages = "440--447",
journal = "Current Opinion in Colloid & Interface Science",
issn = "1359-0294",
publisher = "Pergamon Press",
number = "5",

}

RIS

TY - JOUR

T1 - Small-scale structure in fluid cholesterol-lipid bilayers

AU - Rheinstädter, Maikel C.

AU - Mouritsen, Ole G.

PY - 2013

Y1 - 2013

N2 - Cholesterol is the single most abundant molecule in animal plasma membranes, in the range of 20-30. mol%, where it is known to modulate the lipid-bilayer component of the membrane and lead to increased mechanical stability, lower permeability, larger thickness, and a distinct lateral organization. The phase equilibria of membranes with cholesterol and the associated large- and small-scale structure have turned out to be a particularly elusive problem. With the proposal that lipid domains and so-called 'rafts', characterized by high local levels of cholesterol in a liquid-ordered phase, are important for a wide range of cellular functions, an understanding and a quantitative assessment of the nature of these cholesterol-induced structures and their types of ordering have become urgent. Recent progress in neutron diffraction studies of lipid-cholesterol model membranes has now revealed details of the lateral ordering, and combined with earlier molecular model studies a picture emerges of the membrane as a locally structured liquid with small ordered 'domains' of a highly dynamic nature.

AB - Cholesterol is the single most abundant molecule in animal plasma membranes, in the range of 20-30. mol%, where it is known to modulate the lipid-bilayer component of the membrane and lead to increased mechanical stability, lower permeability, larger thickness, and a distinct lateral organization. The phase equilibria of membranes with cholesterol and the associated large- and small-scale structure have turned out to be a particularly elusive problem. With the proposal that lipid domains and so-called 'rafts', characterized by high local levels of cholesterol in a liquid-ordered phase, are important for a wide range of cellular functions, an understanding and a quantitative assessment of the nature of these cholesterol-induced structures and their types of ordering have become urgent. Recent progress in neutron diffraction studies of lipid-cholesterol model membranes has now revealed details of the lateral ordering, and combined with earlier molecular model studies a picture emerges of the membrane as a locally structured liquid with small ordered 'domains' of a highly dynamic nature.

KW - Cholesterol

KW - Computer simulation

KW - Correlation function

KW - Lipid bilayer

KW - Neutron scattering

KW - Raft

KW - Small-scale structure

U2 - 10.1016/j.cocis.2013.07.001

DO - 10.1016/j.cocis.2013.07.001

M3 - Review

AN - SCOPUS:84882248861

VL - 18

SP - 440

EP - 447

JO - Current Opinion in Colloid & Interface Science

JF - Current Opinion in Colloid & Interface Science

SN - 1359-0294

IS - 5

ER -

ID: 230974908