Diet-associated vertically transferred metabolites and risk of asthma, allergy, eczema, and infections in early childhood
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Diet-associated vertically transferred metabolites and risk of asthma, allergy, eczema, and infections in early childhood. / Brustad, Nicklas; Olarini, Alessandra; Kim, Min; Chen, Liang; Ali, Mina; Wang, Tingting; Cohen, Arieh S.; Ernst, Madeleine; Hougaard, David; Schoos, Ann Marie; Stokholm, Jakob; Bønnelykke, Klaus; Lasky-Su, Jessica; Rasmussen, Morten A.; Chawes, Bo.
In: Pediatric Allergy and Immunology, Vol. 34, No. 2, e13917, 2023.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Diet-associated vertically transferred metabolites and risk of asthma, allergy, eczema, and infections in early childhood
AU - Brustad, Nicklas
AU - Olarini, Alessandra
AU - Kim, Min
AU - Chen, Liang
AU - Ali, Mina
AU - Wang, Tingting
AU - Cohen, Arieh S.
AU - Ernst, Madeleine
AU - Hougaard, David
AU - Schoos, Ann Marie
AU - Stokholm, Jakob
AU - Bønnelykke, Klaus
AU - Lasky-Su, Jessica
AU - Rasmussen, Morten A.
AU - Chawes, Bo
N1 - Publisher Copyright: © 2023 European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.
PY - 2023
Y1 - 2023
N2 - Background: Evidence suggests maternal pregnancy dietary intake and nutrition in the early postnatal period to be of importance for the newborn child's health. However, studies investigating diet-related metabolites transferred from mother to child on disease risk in childhood are lacking. We sought to investigate the influence of vertically transferred metabolites on risk of atopic diseases and infections during preschool age. Methods: In the Danish population-based COPSAC2010 mother–child cohort, information on 10 diet-related vertically transferred metabolites from metabolomics profiles of dried blood spots (DBS) at age 2–3 days was analyzed in relation to the risk of childhood asthma, allergy, eczema, and infections using principal component and single metabolite analyses. Results: In 678 children with DBS measurements, a coffee-related metabolite profile reflected by principal component 1 was inversely associated with risk of asthma (odds ratio (95% CI) 0.78 (0.64; 0.95), p =.014) and eczema at age 6 years (0.79 (0.65; 0.97), p =.022). Furthermore, increasing stachydrine (fruit-related), 3-carboxy-4-methyl-5-propyl-2-furanpropanoate (fish-related), and ergothioneine (fruit-, green vegetables-, and fish-related) levels were all significantly associated with reduced risks of infections at age 0–3 years (p <.05). Conclusion: This study demonstrates associations between pregnancy diet-related vertically transferred metabolites measured in children in early life and risk of atopic diseases and infections in childhood. The specific metabolites associated with a reduced disease risk in children may contribute to the characterization of a healthy nutritional profile in pregnancy using a metabolomics-based unbiased tool for predicting childhood health.
AB - Background: Evidence suggests maternal pregnancy dietary intake and nutrition in the early postnatal period to be of importance for the newborn child's health. However, studies investigating diet-related metabolites transferred from mother to child on disease risk in childhood are lacking. We sought to investigate the influence of vertically transferred metabolites on risk of atopic diseases and infections during preschool age. Methods: In the Danish population-based COPSAC2010 mother–child cohort, information on 10 diet-related vertically transferred metabolites from metabolomics profiles of dried blood spots (DBS) at age 2–3 days was analyzed in relation to the risk of childhood asthma, allergy, eczema, and infections using principal component and single metabolite analyses. Results: In 678 children with DBS measurements, a coffee-related metabolite profile reflected by principal component 1 was inversely associated with risk of asthma (odds ratio (95% CI) 0.78 (0.64; 0.95), p =.014) and eczema at age 6 years (0.79 (0.65; 0.97), p =.022). Furthermore, increasing stachydrine (fruit-related), 3-carboxy-4-methyl-5-propyl-2-furanpropanoate (fish-related), and ergothioneine (fruit-, green vegetables-, and fish-related) levels were all significantly associated with reduced risks of infections at age 0–3 years (p <.05). Conclusion: This study demonstrates associations between pregnancy diet-related vertically transferred metabolites measured in children in early life and risk of atopic diseases and infections in childhood. The specific metabolites associated with a reduced disease risk in children may contribute to the characterization of a healthy nutritional profile in pregnancy using a metabolomics-based unbiased tool for predicting childhood health.
KW - asthma
KW - COPSAC
KW - eczema
KW - infections
KW - metabolomics
U2 - 10.1111/pai.13917
DO - 10.1111/pai.13917
M3 - Journal article
C2 - 36825739
AN - SCOPUS:85148609356
VL - 34
JO - Pediatric Allergy and Immunology, Supplement
JF - Pediatric Allergy and Immunology, Supplement
SN - 0906-5784
IS - 2
M1 - e13917
ER -
ID: 358093886