What's so special about cholesterol?

Research output: Contribution to journalJournal articleResearchpeer-review

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What's so special about cholesterol? / Mouritsen, Ole G.; Zuckermann, Martin J.

In: Lipids, Vol. 39, No. 11, 01.11.2004, p. 1101-1113.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Mouritsen, OG & Zuckermann, MJ 2004, 'What's so special about cholesterol?', Lipids, vol. 39, no. 11, pp. 1101-1113. https://doi.org/10.1007/s11745-004-1336-x

APA

Mouritsen, O. G., & Zuckermann, M. J. (2004). What's so special about cholesterol? Lipids, 39(11), 1101-1113. https://doi.org/10.1007/s11745-004-1336-x

Vancouver

Mouritsen OG, Zuckermann MJ. What's so special about cholesterol? Lipids. 2004 Nov 1;39(11):1101-1113. https://doi.org/10.1007/s11745-004-1336-x

Author

Mouritsen, Ole G. ; Zuckermann, Martin J. / What's so special about cholesterol?. In: Lipids. 2004 ; Vol. 39, No. 11. pp. 1101-1113.

Bibtex

@article{3e6284308f964dd6a7a27cb225c4d6c0,
title = "What's so special about cholesterol?",
abstract = "Cholesterol (or other higher sterols such as ergosterol and phytosterols) is universally present in large amounts (20-40 mol{\%}) in eukaryotic plasma membranes, whereas it is universally absent in the membranes of prokaryotes. Cholesterol has a unique ability to increase lipid order in fluid membranes while maintaining fluidity and diffusion rates. Cholesterol imparts low permeability barriers to lipid membranes and provides for large mechanical coherence. A short topical review is given of these special properties of cholesterol in relation to the structure of membranes, with results drawn from a variety of theoretical and experimental studies. Particular focus is put on cholesterol's ability to promote a special membrane phase, the liquid-ordered phase, which is unique for cholesterol (and other higher sterols like ergosterol) and absent in membranes containing the cholesterol precursor lanosterol. Cholesterol's role in the formation of special membrane domains and so-called rafts is discussed.",
author = "Mouritsen, {Ole G.} and Zuckermann, {Martin J.}",
year = "2004",
month = "11",
day = "1",
doi = "10.1007/s11745-004-1336-x",
language = "English",
volume = "39",
pages = "1101--1113",
journal = "Lipids",
issn = "0024-4201",
publisher = "Springer",
number = "11",

}

RIS

TY - JOUR

T1 - What's so special about cholesterol?

AU - Mouritsen, Ole G.

AU - Zuckermann, Martin J.

PY - 2004/11/1

Y1 - 2004/11/1

N2 - Cholesterol (or other higher sterols such as ergosterol and phytosterols) is universally present in large amounts (20-40 mol%) in eukaryotic plasma membranes, whereas it is universally absent in the membranes of prokaryotes. Cholesterol has a unique ability to increase lipid order in fluid membranes while maintaining fluidity and diffusion rates. Cholesterol imparts low permeability barriers to lipid membranes and provides for large mechanical coherence. A short topical review is given of these special properties of cholesterol in relation to the structure of membranes, with results drawn from a variety of theoretical and experimental studies. Particular focus is put on cholesterol's ability to promote a special membrane phase, the liquid-ordered phase, which is unique for cholesterol (and other higher sterols like ergosterol) and absent in membranes containing the cholesterol precursor lanosterol. Cholesterol's role in the formation of special membrane domains and so-called rafts is discussed.

AB - Cholesterol (or other higher sterols such as ergosterol and phytosterols) is universally present in large amounts (20-40 mol%) in eukaryotic plasma membranes, whereas it is universally absent in the membranes of prokaryotes. Cholesterol has a unique ability to increase lipid order in fluid membranes while maintaining fluidity and diffusion rates. Cholesterol imparts low permeability barriers to lipid membranes and provides for large mechanical coherence. A short topical review is given of these special properties of cholesterol in relation to the structure of membranes, with results drawn from a variety of theoretical and experimental studies. Particular focus is put on cholesterol's ability to promote a special membrane phase, the liquid-ordered phase, which is unique for cholesterol (and other higher sterols like ergosterol) and absent in membranes containing the cholesterol precursor lanosterol. Cholesterol's role in the formation of special membrane domains and so-called rafts is discussed.

UR - http://www.scopus.com/inward/record.url?scp=12344270987&partnerID=8YFLogxK

U2 - 10.1007/s11745-004-1336-x

DO - 10.1007/s11745-004-1336-x

M3 - Journal article

C2 - 15726825

AN - SCOPUS:12344270987

VL - 39

SP - 1101

EP - 1113

JO - Lipids

JF - Lipids

SN - 0024-4201

IS - 11

ER -

ID: 230986067