Targeted-plasticity in the corticospinal tract after human spinal cord injury

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Targeted-plasticity in the corticospinal tract after human spinal cord injury. / Christiansen, Lasse; Perez, Monica A.

In: Neurotherapeutics, Vol. 15, No. 3, 2018, p. 618-627.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Christiansen, L & Perez, MA 2018, 'Targeted-plasticity in the corticospinal tract after human spinal cord injury', Neurotherapeutics, vol. 15, no. 3, pp. 618-627. https://doi.org/10.1007/s13311-018-0639-y

APA

Christiansen, L., & Perez, M. A. (2018). Targeted-plasticity in the corticospinal tract after human spinal cord injury. Neurotherapeutics, 15(3), 618-627. https://doi.org/10.1007/s13311-018-0639-y

Vancouver

Christiansen L, Perez MA. Targeted-plasticity in the corticospinal tract after human spinal cord injury. Neurotherapeutics. 2018;15(3):618-627. https://doi.org/10.1007/s13311-018-0639-y

Author

Christiansen, Lasse ; Perez, Monica A. / Targeted-plasticity in the corticospinal tract after human spinal cord injury. In: Neurotherapeutics. 2018 ; Vol. 15, No. 3. pp. 618-627.

Bibtex

@article{ac939a0dc3b04dc48f861e790224af7d,
title = "Targeted-plasticity in the corticospinal tract after human spinal cord injury",
abstract = "Spinal cord injury (SCI) often results in impaired or absent sensorimotor function below the level of the lesion. Recent electrophysiological studies in humans with chronic incomplete SCI demonstrate that voluntary motor output can be to some extent potentiated by noninvasive stimulation that targets the corticospinal tract. We discuss emerging approaches that use transcranial magnetic stimulation (TMS) over the primary motor cortex and electrical stimulation over a peripheral nerve as tools to induce plasticity in residual corticospinal projections. A single TMS pulse over the primary motor cortex has been paired with peripheral nerve electrical stimulation at precise interstimulus intervals to reinforce corticospinal synaptic transmission using principles of spike-timing dependent plasticity. Pairs of TMS pulses have also been used at interstimulus intervals that mimic the periodicity of descending indirect (I) waves volleys in the corticospinal tract. This data, along with information about the extent of the injury, provides a new framework for exploring the contribution of the corticospinal tract to recovery of function following SCI.",
keywords = "Faculty of Science, Noninvasive brain stimulation, Physiology of magnetic stimulation, Spinal cord injury, Rehabilitation, Spinal plasticity",
author = "Lasse Christiansen and Perez, {Monica A}",
year = "2018",
doi = "10.1007/s13311-018-0639-y",
language = "English",
volume = "15",
pages = "618--627",
journal = "Neurotherapeutics",
issn = "1933-7213",
publisher = "Springer",
number = "3",

}

RIS

TY - JOUR

T1 - Targeted-plasticity in the corticospinal tract after human spinal cord injury

AU - Christiansen, Lasse

AU - Perez, Monica A

PY - 2018

Y1 - 2018

N2 - Spinal cord injury (SCI) often results in impaired or absent sensorimotor function below the level of the lesion. Recent electrophysiological studies in humans with chronic incomplete SCI demonstrate that voluntary motor output can be to some extent potentiated by noninvasive stimulation that targets the corticospinal tract. We discuss emerging approaches that use transcranial magnetic stimulation (TMS) over the primary motor cortex and electrical stimulation over a peripheral nerve as tools to induce plasticity in residual corticospinal projections. A single TMS pulse over the primary motor cortex has been paired with peripheral nerve electrical stimulation at precise interstimulus intervals to reinforce corticospinal synaptic transmission using principles of spike-timing dependent plasticity. Pairs of TMS pulses have also been used at interstimulus intervals that mimic the periodicity of descending indirect (I) waves volleys in the corticospinal tract. This data, along with information about the extent of the injury, provides a new framework for exploring the contribution of the corticospinal tract to recovery of function following SCI.

AB - Spinal cord injury (SCI) often results in impaired or absent sensorimotor function below the level of the lesion. Recent electrophysiological studies in humans with chronic incomplete SCI demonstrate that voluntary motor output can be to some extent potentiated by noninvasive stimulation that targets the corticospinal tract. We discuss emerging approaches that use transcranial magnetic stimulation (TMS) over the primary motor cortex and electrical stimulation over a peripheral nerve as tools to induce plasticity in residual corticospinal projections. A single TMS pulse over the primary motor cortex has been paired with peripheral nerve electrical stimulation at precise interstimulus intervals to reinforce corticospinal synaptic transmission using principles of spike-timing dependent plasticity. Pairs of TMS pulses have also been used at interstimulus intervals that mimic the periodicity of descending indirect (I) waves volleys in the corticospinal tract. This data, along with information about the extent of the injury, provides a new framework for exploring the contribution of the corticospinal tract to recovery of function following SCI.

KW - Faculty of Science

KW - Noninvasive brain stimulation

KW - Physiology of magnetic stimulation

KW - Spinal cord injury

KW - Rehabilitation

KW - Spinal plasticity

U2 - 10.1007/s13311-018-0639-y

DO - 10.1007/s13311-018-0639-y

M3 - Review

C2 - 29946981

VL - 15

SP - 618

EP - 627

JO - Neurotherapeutics

JF - Neurotherapeutics

SN - 1933-7213

IS - 3

ER -

ID: 213042614