Stem cell therapy for joint problems using the horse as a clinically relevant animal model

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Stem cell therapy for joint problems using the horse as a clinically relevant animal model. / Koch, Thomas Gadegaard; Betts, Dean H.

In: Expert Opinion on Biological Therapy, Vol. 7, No. 11, 2007, p. 1621-1626.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Koch, TG & Betts, DH 2007, 'Stem cell therapy for joint problems using the horse as a clinically relevant animal model', Expert Opinion on Biological Therapy, vol. 7, no. 11, pp. 1621-1626. https://doi.org/10.1517/14712598.7.11.1621

APA

Koch, T. G., & Betts, D. H. (2007). Stem cell therapy for joint problems using the horse as a clinically relevant animal model. Expert Opinion on Biological Therapy, 7(11), 1621-1626. https://doi.org/10.1517/14712598.7.11.1621

Vancouver

Koch TG, Betts DH. Stem cell therapy for joint problems using the horse as a clinically relevant animal model. Expert Opinion on Biological Therapy. 2007;7(11):1621-1626. https://doi.org/10.1517/14712598.7.11.1621

Author

Koch, Thomas Gadegaard ; Betts, Dean H. / Stem cell therapy for joint problems using the horse as a clinically relevant animal model. In: Expert Opinion on Biological Therapy. 2007 ; Vol. 7, No. 11. pp. 1621-1626.

Bibtex

@article{c2a76d70a1c311ddb6ae000ea68e967b,
title = "Stem cell therapy for joint problems using the horse as a clinically relevant animal model",
abstract = "Research into articular cartilage is a surprisingly recent endeavour and much remains to be learned about the normal development of the synovial joint and its components that interplay in osteoarthritis and focal cartilage defects. Stem cell research is likely to contribute to the understanding of the developmental biology of synovial joints and their pathologies. Before human clinical trials are undertaken, stem cell-based therapies for non-life-threatening disorders should be evaluated for their safety and efficacy using animal models of spontaneous disease and not solely by the existing laboratory models of experimentally induced lesions. The horse lends itself as a good animal model of spontaneous joint disorders that are clinically relevant to similar human disorders. Equine stem cell and tissue engineering studies may be financially feasible to principal investigators and small biotechnology companies if the equine industry is successfully engaged in the research process.",
keywords = "Former LIFE faculty, animal models, cartilage, domestic animals, equine, osteoarthritis, stem cells, tissue engineering",
author = "Koch, {Thomas Gadegaard} and Betts, {Dean H.}",
year = "2007",
doi = "10.1517/14712598.7.11.1621",
language = "English",
volume = "7",
pages = "1621--1626",
journal = "Expert Opinion on Biological Therapy",
issn = "1471-2598",
publisher = "Taylor & Francis",
number = "11",

}

RIS

TY - JOUR

T1 - Stem cell therapy for joint problems using the horse as a clinically relevant animal model

AU - Koch, Thomas Gadegaard

AU - Betts, Dean H.

PY - 2007

Y1 - 2007

N2 - Research into articular cartilage is a surprisingly recent endeavour and much remains to be learned about the normal development of the synovial joint and its components that interplay in osteoarthritis and focal cartilage defects. Stem cell research is likely to contribute to the understanding of the developmental biology of synovial joints and their pathologies. Before human clinical trials are undertaken, stem cell-based therapies for non-life-threatening disorders should be evaluated for their safety and efficacy using animal models of spontaneous disease and not solely by the existing laboratory models of experimentally induced lesions. The horse lends itself as a good animal model of spontaneous joint disorders that are clinically relevant to similar human disorders. Equine stem cell and tissue engineering studies may be financially feasible to principal investigators and small biotechnology companies if the equine industry is successfully engaged in the research process.

AB - Research into articular cartilage is a surprisingly recent endeavour and much remains to be learned about the normal development of the synovial joint and its components that interplay in osteoarthritis and focal cartilage defects. Stem cell research is likely to contribute to the understanding of the developmental biology of synovial joints and their pathologies. Before human clinical trials are undertaken, stem cell-based therapies for non-life-threatening disorders should be evaluated for their safety and efficacy using animal models of spontaneous disease and not solely by the existing laboratory models of experimentally induced lesions. The horse lends itself as a good animal model of spontaneous joint disorders that are clinically relevant to similar human disorders. Equine stem cell and tissue engineering studies may be financially feasible to principal investigators and small biotechnology companies if the equine industry is successfully engaged in the research process.

KW - Former LIFE faculty

KW - animal models

KW - cartilage

KW - domestic animals

KW - equine

KW - osteoarthritis

KW - stem cells

KW - tissue engineering

U2 - 10.1517/14712598.7.11.1621

DO - 10.1517/14712598.7.11.1621

M3 - Journal article

C2 - 17961087

VL - 7

SP - 1621

EP - 1626

JO - Expert Opinion on Biological Therapy

JF - Expert Opinion on Biological Therapy

SN - 1471-2598

IS - 11

ER -

ID: 8101880