Starch/Poly(glycerol-adipate) Nanocomposites: A Novel Oral Drug Delivery Device
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- Starch_Poly_glycerol-adipate_Nanocomposites
Final published version, 2.54 MB, PDF document
Biocompatible and bio-based materials are an appealing resource for the pharmaceutical industry. Poly(glycerol-adipate) (PGA) is a biocompatible and biodegradable polymer that can be used to produce self-assembled nanoparticles (NPs) able to encapsulate active ingredients, with encouraging perspectives for drug delivery purposes. Starch is a versatile, inexpensive, and abundant polysaccharide that can be effectively applied as a bio-scaffold for other molecules in order to enrich it with new appealing properties. In this work, the combination of PGA NPs and starch films proved to be a suitable biopolymeric matrix carrier for the controlled release preparation of hydrophobic drugs. Dynamic Light Scattering (DLS) was used to determine the size of drug-loaded PGA NPs, while the improvement of the apparent drug water solubility was assessed by UV-vis spectroscopy. In vitro biological assays were performed against cancer cell lines and bacteria strains to confirm that drug-loaded PGA NPs maintained the effective activity of the therapeutic agents. Dye-conjugated PGA was then exploited to track the NP release profile during the starch/PGA nanocomposite film digestion, which was assessed using digestion models mimicking physiological conditions. The collected data provide a clear indication of the suitability of our biodegradable carrier system for oral drug delivery.
Original language | English |
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Article number | 125 |
Journal | Coatings |
Volume | 10 |
Issue number | 2 |
Number of pages | 15 |
DOIs | |
Publication status | Published - 2020 |
- Biocompatible, Biomaterial, Drug delivery, Nanocomposites, Nanoparticles, Poly(glycerol-adipate), Polymer, Starch
Research areas
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