Slow lactate gluconate exchange in calcium complexes during precipitation from supersaturated aqueous solutions
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Slow lactate gluconate exchange in calcium complexes during precipitation from supersaturated aqueous solutions. / Garcia, André C.; Hansen, Jesper S.; Bailey, Nicholas; Skibsted, Leif H.
In: Food Research International, Vol. 137, 109539, 2020.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Slow lactate gluconate exchange in calcium complexes during precipitation from supersaturated aqueous solutions
AU - Garcia, André C.
AU - Hansen, Jesper S.
AU - Bailey, Nicholas
AU - Skibsted, Leif H.
PY - 2020
Y1 - 2020
N2 - Saturated solutions of calcium L-lactate in water or in deuterium oxide continuously dissolve calcium L-lactate by addition of solid sodium D-gluconate and become strongly supersaturated in calcium D-gluconate due to no or slow precipitation. The quantification of total dissolved calcium allied with the calcium complexes equilibrium constants allowed an ion speciation, which shows an initial non-thermal and spontaneous supersaturation of more than a factor of 50 at 25 °C only slowly decreasing after initiation of precipitation of calcium D-gluconate after a lag phase of several hours. A mathematical model is proposed, based on numerical solution of coupled differential equations of dynamics of L-lactate and D-gluconate exchange during the lag phase for precipitation and during precipitation. A slow exchange of L-lactate coordinated to calcium with D-gluconate is indicated with a time constant of 0.20 h−1 in water and of 0.15 h−1 in deuterium oxide and a kinetic deuterium/hydrogen isotope effect of 1.25. Such spontaneous non-thermal supersaturation and slow ligand exchange with a pseudo first order equilibration process with a half-life of 3.5 h in water for calcium hydroxycarboxylates can help to understand the higher calcium bioavailability from calcium hydroxycarboxylates compared to simple salts.
AB - Saturated solutions of calcium L-lactate in water or in deuterium oxide continuously dissolve calcium L-lactate by addition of solid sodium D-gluconate and become strongly supersaturated in calcium D-gluconate due to no or slow precipitation. The quantification of total dissolved calcium allied with the calcium complexes equilibrium constants allowed an ion speciation, which shows an initial non-thermal and spontaneous supersaturation of more than a factor of 50 at 25 °C only slowly decreasing after initiation of precipitation of calcium D-gluconate after a lag phase of several hours. A mathematical model is proposed, based on numerical solution of coupled differential equations of dynamics of L-lactate and D-gluconate exchange during the lag phase for precipitation and during precipitation. A slow exchange of L-lactate coordinated to calcium with D-gluconate is indicated with a time constant of 0.20 h−1 in water and of 0.15 h−1 in deuterium oxide and a kinetic deuterium/hydrogen isotope effect of 1.25. Such spontaneous non-thermal supersaturation and slow ligand exchange with a pseudo first order equilibration process with a half-life of 3.5 h in water for calcium hydroxycarboxylates can help to understand the higher calcium bioavailability from calcium hydroxycarboxylates compared to simple salts.
KW - Calcium hydroxycarboxylates
KW - Kinetic modelling
KW - Supersaturation
U2 - 10.1016/j.foodres.2020.109539
DO - 10.1016/j.foodres.2020.109539
M3 - Journal article
C2 - 33233167
AN - SCOPUS:85088014320
VL - 137
JO - Food Research International
JF - Food Research International
SN - 0963-9969
M1 - 109539
ER -
ID: 248030592