Secreted phospholipase A2 as a new enzymatic trigger mechanism for localised liposomal drug release and absorption in diseased tissue

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Secreted phospholipase A2 as a new enzymatic trigger mechanism for localised liposomal drug release and absorption in diseased tissue. / Davidsen, Jesper; Jørgensen, Kent; Andresen, Thomas L.; Mouritsen, Ole G.

In: Biochimica et Biophysica Acta - Biomembranes, Vol. 1609, No. 1, 10.01.2003, p. 95-101.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Davidsen, J, Jørgensen, K, Andresen, TL & Mouritsen, OG 2003, 'Secreted phospholipase A2 as a new enzymatic trigger mechanism for localised liposomal drug release and absorption in diseased tissue', Biochimica et Biophysica Acta - Biomembranes, vol. 1609, no. 1, pp. 95-101. https://doi.org/10.1016/S0005-2736(02)00659-4

APA

Davidsen, J., Jørgensen, K., Andresen, T. L., & Mouritsen, O. G. (2003). Secreted phospholipase A2 as a new enzymatic trigger mechanism for localised liposomal drug release and absorption in diseased tissue. Biochimica et Biophysica Acta - Biomembranes, 1609(1), 95-101. https://doi.org/10.1016/S0005-2736(02)00659-4

Vancouver

Davidsen J, Jørgensen K, Andresen TL, Mouritsen OG. Secreted phospholipase A2 as a new enzymatic trigger mechanism for localised liposomal drug release and absorption in diseased tissue. Biochimica et Biophysica Acta - Biomembranes. 2003 Jan 10;1609(1):95-101. https://doi.org/10.1016/S0005-2736(02)00659-4

Author

Davidsen, Jesper ; Jørgensen, Kent ; Andresen, Thomas L. ; Mouritsen, Ole G. / Secreted phospholipase A2 as a new enzymatic trigger mechanism for localised liposomal drug release and absorption in diseased tissue. In: Biochimica et Biophysica Acta - Biomembranes. 2003 ; Vol. 1609, No. 1. pp. 95-101.

Bibtex

@article{3eb95e03f90544b3bff100d180b32e1d,
title = "Secreted phospholipase A2 as a new enzymatic trigger mechanism for localised liposomal drug release and absorption in diseased tissue",
abstract = "Polymer-coated liposomes can act as versatile drug-delivery systems due to long vascular circulation time and passive targeting by leaky blood vessels in diseased tissue. We present an experimental model system illustrating a new principle for improved and programmable drug-delivery, which takes advantage of an elevated activity of secretory phospholipase A2 (PLA2) at the diseased target tissue. The secretory PLA2 hydrolyses a lipid-based proenhancer in the carrier liposome, producing lyso-phospholipids and free fatty acids, which are shown in a synergistic way to lead to enhanced liposome destabilization and drug release at the same time as the permeability of the target membrane is enhanced. Moreover, the proposed system can be made thermosensitive and offers a rational way for developing smart liposome-based drug delivery systems. This can be achieved by incorporating specific lipid-based proenhancers or prodestabilisers into the liposome carrier, which automatically becomes activated by PLA2 only at the diseased target sites, such as inflamed or cancerous tissue.",
keywords = "Drug delivery, Enhancer, Fatty acid, Liposome, Lyso-phospholipid, Membrane, Permeability, Phospholipase A, Surfactant",
author = "Jesper Davidsen and Kent J{\o}rgensen and Andresen, {Thomas L.} and Mouritsen, {Ole G.}",
year = "2003",
month = "1",
day = "10",
doi = "10.1016/S0005-2736(02)00659-4",
language = "English",
volume = "1609",
pages = "95--101",
journal = "B B A - Biomembranes",
issn = "0005-2736",
publisher = "Elsevier",
number = "1",

}

RIS

TY - JOUR

T1 - Secreted phospholipase A2 as a new enzymatic trigger mechanism for localised liposomal drug release and absorption in diseased tissue

AU - Davidsen, Jesper

AU - Jørgensen, Kent

AU - Andresen, Thomas L.

AU - Mouritsen, Ole G.

PY - 2003/1/10

Y1 - 2003/1/10

N2 - Polymer-coated liposomes can act as versatile drug-delivery systems due to long vascular circulation time and passive targeting by leaky blood vessels in diseased tissue. We present an experimental model system illustrating a new principle for improved and programmable drug-delivery, which takes advantage of an elevated activity of secretory phospholipase A2 (PLA2) at the diseased target tissue. The secretory PLA2 hydrolyses a lipid-based proenhancer in the carrier liposome, producing lyso-phospholipids and free fatty acids, which are shown in a synergistic way to lead to enhanced liposome destabilization and drug release at the same time as the permeability of the target membrane is enhanced. Moreover, the proposed system can be made thermosensitive and offers a rational way for developing smart liposome-based drug delivery systems. This can be achieved by incorporating specific lipid-based proenhancers or prodestabilisers into the liposome carrier, which automatically becomes activated by PLA2 only at the diseased target sites, such as inflamed or cancerous tissue.

AB - Polymer-coated liposomes can act as versatile drug-delivery systems due to long vascular circulation time and passive targeting by leaky blood vessels in diseased tissue. We present an experimental model system illustrating a new principle for improved and programmable drug-delivery, which takes advantage of an elevated activity of secretory phospholipase A2 (PLA2) at the diseased target tissue. The secretory PLA2 hydrolyses a lipid-based proenhancer in the carrier liposome, producing lyso-phospholipids and free fatty acids, which are shown in a synergistic way to lead to enhanced liposome destabilization and drug release at the same time as the permeability of the target membrane is enhanced. Moreover, the proposed system can be made thermosensitive and offers a rational way for developing smart liposome-based drug delivery systems. This can be achieved by incorporating specific lipid-based proenhancers or prodestabilisers into the liposome carrier, which automatically becomes activated by PLA2 only at the diseased target sites, such as inflamed or cancerous tissue.

KW - Drug delivery

KW - Enhancer

KW - Fatty acid

KW - Liposome

KW - Lyso-phospholipid

KW - Membrane

KW - Permeability

KW - Phospholipase A

KW - Surfactant

UR - http://www.scopus.com/inward/record.url?scp=0037427971&partnerID=8YFLogxK

U2 - 10.1016/S0005-2736(02)00659-4

DO - 10.1016/S0005-2736(02)00659-4

M3 - Journal article

C2 - 12507763

AN - SCOPUS:0037427971

VL - 1609

SP - 95

EP - 101

JO - B B A - Biomembranes

JF - B B A - Biomembranes

SN - 0005-2736

IS - 1

ER -

ID: 230986431