Molecular evolution of cholesterol and other higher sterols in relation to membrane structure

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Standard

Molecular evolution of cholesterol and other higher sterols in relation to membrane structure. / Mouritsen, Ole G.

Cholesterol: From Chemistry and Biophysics to the Clinic. ed. / Anna N. Bukiya; Alex M. Dopio. Elsevier, 2022. p. 25-40.

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Harvard

Mouritsen, OG 2022, Molecular evolution of cholesterol and other higher sterols in relation to membrane structure. in AN Bukiya & AM Dopio (eds), Cholesterol: From Chemistry and Biophysics to the Clinic. Elsevier, pp. 25-40. https://doi.org/10.1016/C2020-0-01766-4, https://doi.org/10.1016/B978-0-323-85857-1.00013-4, https://doi.org/10.1016/B978-0-323-85857-1.00013-4

APA

Mouritsen, O. G. (2022). Molecular evolution of cholesterol and other higher sterols in relation to membrane structure. In A. N. Bukiya, & A. M. Dopio (Eds.), Cholesterol: From Chemistry and Biophysics to the Clinic (pp. 25-40). Elsevier. https://doi.org/10.1016/C2020-0-01766-4, https://doi.org/10.1016/B978-0-323-85857-1.00013-4, https://doi.org/10.1016/B978-0-323-85857-1.00013-4

Vancouver

Mouritsen OG. Molecular evolution of cholesterol and other higher sterols in relation to membrane structure. In Bukiya AN, Dopio AM, editors, Cholesterol: From Chemistry and Biophysics to the Clinic. Elsevier. 2022. p. 25-40 https://doi.org/10.1016/C2020-0-01766-4, https://doi.org/10.1016/B978-0-323-85857-1.00013-4, https://doi.org/10.1016/B978-0-323-85857-1.00013-4

Author

Mouritsen, Ole G. / Molecular evolution of cholesterol and other higher sterols in relation to membrane structure. Cholesterol: From Chemistry and Biophysics to the Clinic. editor / Anna N. Bukiya ; Alex M. Dopio. Elsevier, 2022. pp. 25-40

Bibtex

@inbook{db76bd5aeeb8483b89ca65a9241d48a7,
title = "Molecular evolution of cholesterol and other higher sterols in relation to membrane structure",
abstract = "The lipidomes of cell membranes, cells, organs, and the human body are immense, reflecting that many different lipids are involved in a wide range of important and diverse biochemical and physiological functions. However, one specific type of lipid, cholesterol, stands out as a unique case being the single most abundant type of molecule in all animal plasma membranes which typically contain about 20% to 30% cholesterol. Even if derivatives of cholesterol are engaged in a host of biochemical processes, the simple cholesterol molecule itself seems by evolution to have been selected for its unique ability to modulate the physical state of membranes. Other higher sterols, such as sitosterol, ergosterol, and fucosterol, appear to have been evolved to serve a similar function in the kingdoms of plants, fungi, and algae, respectively.",
keywords = "Cholesterol, Evolution, Higher sterols, Lipids, Liquid-ordered phase, Membrane structure",
author = "Mouritsen, {Ole G.}",
year = "2022",
doi = "10.1016/C2020-0-01766-4",
language = "English",
isbn = "978-0-323-85857-1",
pages = "25--40",
editor = "Bukiya, {Anna N.} and Dopio, {Alex M.}",
booktitle = "Cholesterol",
publisher = "Elsevier",
address = "Netherlands",

}

RIS

TY - CHAP

T1 - Molecular evolution of cholesterol and other higher sterols in relation to membrane structure

AU - Mouritsen, Ole G.

PY - 2022

Y1 - 2022

N2 - The lipidomes of cell membranes, cells, organs, and the human body are immense, reflecting that many different lipids are involved in a wide range of important and diverse biochemical and physiological functions. However, one specific type of lipid, cholesterol, stands out as a unique case being the single most abundant type of molecule in all animal plasma membranes which typically contain about 20% to 30% cholesterol. Even if derivatives of cholesterol are engaged in a host of biochemical processes, the simple cholesterol molecule itself seems by evolution to have been selected for its unique ability to modulate the physical state of membranes. Other higher sterols, such as sitosterol, ergosterol, and fucosterol, appear to have been evolved to serve a similar function in the kingdoms of plants, fungi, and algae, respectively.

AB - The lipidomes of cell membranes, cells, organs, and the human body are immense, reflecting that many different lipids are involved in a wide range of important and diverse biochemical and physiological functions. However, one specific type of lipid, cholesterol, stands out as a unique case being the single most abundant type of molecule in all animal plasma membranes which typically contain about 20% to 30% cholesterol. Even if derivatives of cholesterol are engaged in a host of biochemical processes, the simple cholesterol molecule itself seems by evolution to have been selected for its unique ability to modulate the physical state of membranes. Other higher sterols, such as sitosterol, ergosterol, and fucosterol, appear to have been evolved to serve a similar function in the kingdoms of plants, fungi, and algae, respectively.

KW - Cholesterol

KW - Evolution

KW - Higher sterols

KW - Lipids

KW - Liquid-ordered phase

KW - Membrane structure

U2 - 10.1016/C2020-0-01766-4

DO - 10.1016/C2020-0-01766-4

M3 - Book chapter

AN - SCOPUS:85138848114

SN - 978-0-323-85857-1

SN - 9780323858588

SP - 25

EP - 40

BT - Cholesterol

A2 - Bukiya, Anna N.

A2 - Dopio, Alex M.

PB - Elsevier

ER -

ID: 303370178