Membrane Protein-Lipid Match and Mismatch

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  • O. G. Mouritsen

Lipid-protein interactions are described with a focus on the physical interactions between lipids and integral proteins in lipid-bilayer membranes. The concepts of hydrophobic matching and curvature stress are presented and the effects of match vs mismatch is considered in light of data obtained from experimental and theoretical studies which demonstrate that not only do integral proteins perturb the lipids, but the physical state of the lipids does also actively influence protein function.

Original languageEnglish
Title of host publicationComprehensive Biophysics
EditorsEdward H. Egelman
Number of pages16
Volume5
PublisherElsevier
Publication date2012
Pages245-260
Chapter5.12
ISBN (Print)978-0-08-095718-0
DOIs
Publication statusPublished - 2012
Externally publishedYes

    Research areas

  • Hydrophobic matching, Hydrophobic thickness, Integral membrane protein, Lipid bilayer, Membrane organization, Structure-function relationship, Wetting

ID: 230975019