In situ atomic force microscope imaging of supported lipid bilayers

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In situ AFM images of phospholipase A2 (PLA2) hydrolysis of mica-supported one- and two-component lipid bilayers are presented. For one-component DPPC bilayers an enhanced enzymatic activity is observed towards preexisting defects in the bilayer. Phase separation is observed in two-component DMPC-DSPC bilayers and a remarkable enhanced hydrolytic activity of the PLA2-enzyme for the DMPC-rich phase is seen. Furthermore, in a supported double bilayer system a characteristic ripple structure, most likely related to the formation of the Pβ'-ripple phase is observed.

Original languageEnglish
JournalSingle Molecules
Issue number2
Pages (from-to)105-108
Number of pages4
Publication statusPublished - 1 Jan 2001

ID: 236896940