Functional importance of the astrocytic glycogen-shunt and glycolysis for maintenance of an intact intra/extracellular glutamate gradient

Research output: Contribution to journal › Journal article › Research › peer-review

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Functional importance of the astrocytic glycogen-shunt and glycolysis for maintenance of an intact intra/extracellular glutamate gradient. / Schousboe, Arne; Sickmann, Helle M; Walls, Anne B; Bak, Lasse K; Waagepetersen, Helle S.

In: Neurotoxicity Research, Vol. 18, No. 1, 2010, p. 94-9.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Schousboe, A, Sickmann, HM, Walls, AB, Bak, LK & Waagepetersen, HS 2010, 'Functional importance of the astrocytic glycogen-shunt and glycolysis for maintenance of an intact intra/extracellular glutamate gradient', Neurotoxicity Research, vol. 18, no. 1, pp. 94-9. https://doi.org/10.1007/s12640-010-9171-5

APA

Schousboe, A., Sickmann, H. M., Walls, A. B., Bak, L. K., & Waagepetersen, H. S. (2010). Functional importance of the astrocytic glycogen-shunt and glycolysis for maintenance of an intact intra/extracellular glutamate gradient. Neurotoxicity Research, 18(1), 94-9. https://doi.org/10.1007/s12640-010-9171-5

Vancouver

Schousboe A, Sickmann HM, Walls AB, Bak LK, Waagepetersen HS. Functional importance of the astrocytic glycogen-shunt and glycolysis for maintenance of an intact intra/extracellular glutamate gradient. Neurotoxicity Research. 2010;18(1):94-9. https://doi.org/10.1007/s12640-010-9171-5

Author

Schousboe, Arne ; Sickmann, Helle M ; Walls, Anne B ; Bak, Lasse K ; Waagepetersen, Helle S. / Functional importance of the astrocytic glycogen-shunt and glycolysis for maintenance of an intact intra/extracellular glutamate gradient. In: Neurotoxicity Research. 2010 ; Vol. 18, No. 1. pp. 94-9.

Bibtex

@article{b4dd939077aa11df928f000ea68e967b,
title = "Functional importance of the astrocytic glycogen-shunt and glycolysis for maintenance of an intact intra/extracellular glutamate gradient",
abstract = "It has been proposed that a considerable fraction of glucose metabolism proceeds via the glycogen-shunt consisting of conversion of glucose units to glycogen residues and subsequent production of glucose-1-phosphate to be metabolized in glycolysis after conversion to glucose-6-phosphate. The importance of this as well as the significance of ATP formed in glycolysis versus that formed by the concerted action of the tricarboxylic acid (TCA) cycle processes and oxidative phosphorylation for maintenance of glutamate transport capacity in astrocytes is discussed. It is argued that glycolytically derived energy in the form of ATP may be of particular functional importance in this context.",
keywords = "Former Faculty of Pharmaceutical Sciences",
author = "Arne Schousboe and Sickmann, {Helle M} and Walls, {Anne B} and Bak, {Lasse K} and Waagepetersen, {Helle S}",
year = "2010",
doi = "10.1007/s12640-010-9171-5",
language = "English",
volume = "18",
pages = "94--9",
journal = "Neurotoxicity Research",
issn = "1029-8428",
publisher = "Springer",
number = "1",

}

RIS

TY - JOUR

T1 - Functional importance of the astrocytic glycogen-shunt and glycolysis for maintenance of an intact intra/extracellular glutamate gradient

AU - Schousboe, Arne

AU - Sickmann, Helle M

AU - Walls, Anne B

AU - Bak, Lasse K

AU - Waagepetersen, Helle S

PY - 2010

Y1 - 2010

N2 - It has been proposed that a considerable fraction of glucose metabolism proceeds via the glycogen-shunt consisting of conversion of glucose units to glycogen residues and subsequent production of glucose-1-phosphate to be metabolized in glycolysis after conversion to glucose-6-phosphate. The importance of this as well as the significance of ATP formed in glycolysis versus that formed by the concerted action of the tricarboxylic acid (TCA) cycle processes and oxidative phosphorylation for maintenance of glutamate transport capacity in astrocytes is discussed. It is argued that glycolytically derived energy in the form of ATP may be of particular functional importance in this context.

AB - It has been proposed that a considerable fraction of glucose metabolism proceeds via the glycogen-shunt consisting of conversion of glucose units to glycogen residues and subsequent production of glucose-1-phosphate to be metabolized in glycolysis after conversion to glucose-6-phosphate. The importance of this as well as the significance of ATP formed in glycolysis versus that formed by the concerted action of the tricarboxylic acid (TCA) cycle processes and oxidative phosphorylation for maintenance of glutamate transport capacity in astrocytes is discussed. It is argued that glycolytically derived energy in the form of ATP may be of particular functional importance in this context.

KW - Former Faculty of Pharmaceutical Sciences

U2 - 10.1007/s12640-010-9171-5

DO - 10.1007/s12640-010-9171-5

M3 - Journal article

C2 - 20306167

VL - 18

SP - 94

EP - 99

JO - Neurotoxicity Research

JF - Neurotoxicity Research

SN - 1029-8428

IS - 1

ER -

ID: 20295984