Exocrine pancreatic insufficiency in the Eurasian dog breed - inheritance and exclusion of two candidate genes

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Standard

Exocrine pancreatic insufficiency in the Eurasian dog breed - inheritance and exclusion of two candidate genes. / Proschowsky, Helle Friis; Fredholm, Merete.

In: Animal Genetics, Vol. 38, No. 2, 2007, p. 171-173.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Proschowsky, HF & Fredholm, M 2007, 'Exocrine pancreatic insufficiency in the Eurasian dog breed - inheritance and exclusion of two candidate genes', Animal Genetics, vol. 38, no. 2, pp. 171-173. https://doi.org/10.1111/j.1365-2052.2007.01570.x

APA

Proschowsky, H. F., & Fredholm, M. (2007). Exocrine pancreatic insufficiency in the Eurasian dog breed - inheritance and exclusion of two candidate genes. Animal Genetics, 38(2), 171-173. https://doi.org/10.1111/j.1365-2052.2007.01570.x

Vancouver

Proschowsky HF, Fredholm M. Exocrine pancreatic insufficiency in the Eurasian dog breed - inheritance and exclusion of two candidate genes. Animal Genetics. 2007;38(2):171-173. https://doi.org/10.1111/j.1365-2052.2007.01570.x

Author

Proschowsky, Helle Friis ; Fredholm, Merete. / Exocrine pancreatic insufficiency in the Eurasian dog breed - inheritance and exclusion of two candidate genes. In: Animal Genetics. 2007 ; Vol. 38, No. 2. pp. 171-173.

Bibtex

@article{85c83200a1c211ddb6ae000ea68e967b,
title = "Exocrine pancreatic insufficiency in the Eurasian dog breed - inheritance and exclusion of two candidate genes",
abstract = "Exocrine pancreatic insufficiency is considered an inherited disease in several dog breeds. Affected dogs show polyphagia, weight loss and voluminous faeces of light colour due to the lack of pancreatic enzymes. In the study described herein, we performed a segregation analysis using the SINGLES method for three families of the Eurasian dog breed. Our data were consistent with an autosomal recessive mode of inheritance. In addition, we performed a linkage analysis in these families using four microsatellite markers on CFA3 and two microsatellites on CFA23. Based on our results, we excluded the canine orthologs of the human cholecystokinin (CCK) and the cholecystokinin A receptor (CCKAR) genes as candidates for exocrine pancreatic insufficiency.",
keywords = "Former LIFE faculty, canine, cholecystokinin, Eurasian dog, exocrine pancreaTIC insufficiency, inheritance, segregation",
author = "Proschowsky, {Helle Friis} and Merete Fredholm",
year = "2007",
doi = "10.1111/j.1365-2052.2007.01570.x",
language = "English",
volume = "38",
pages = "171--173",
journal = "Animal Genetics",
issn = "0268-9146",
publisher = "Wiley-Blackwell",
number = "2",

}

RIS

TY - JOUR

T1 - Exocrine pancreatic insufficiency in the Eurasian dog breed - inheritance and exclusion of two candidate genes

AU - Proschowsky, Helle Friis

AU - Fredholm, Merete

PY - 2007

Y1 - 2007

N2 - Exocrine pancreatic insufficiency is considered an inherited disease in several dog breeds. Affected dogs show polyphagia, weight loss and voluminous faeces of light colour due to the lack of pancreatic enzymes. In the study described herein, we performed a segregation analysis using the SINGLES method for three families of the Eurasian dog breed. Our data were consistent with an autosomal recessive mode of inheritance. In addition, we performed a linkage analysis in these families using four microsatellite markers on CFA3 and two microsatellites on CFA23. Based on our results, we excluded the canine orthologs of the human cholecystokinin (CCK) and the cholecystokinin A receptor (CCKAR) genes as candidates for exocrine pancreatic insufficiency.

AB - Exocrine pancreatic insufficiency is considered an inherited disease in several dog breeds. Affected dogs show polyphagia, weight loss and voluminous faeces of light colour due to the lack of pancreatic enzymes. In the study described herein, we performed a segregation analysis using the SINGLES method for three families of the Eurasian dog breed. Our data were consistent with an autosomal recessive mode of inheritance. In addition, we performed a linkage analysis in these families using four microsatellite markers on CFA3 and two microsatellites on CFA23. Based on our results, we excluded the canine orthologs of the human cholecystokinin (CCK) and the cholecystokinin A receptor (CCKAR) genes as candidates for exocrine pancreatic insufficiency.

KW - Former LIFE faculty

KW - canine

KW - cholecystokinin

KW - Eurasian dog

KW - exocrine pancreaTIC insufficiency

KW - inheritance

KW - segregation

U2 - 10.1111/j.1365-2052.2007.01570.x

DO - 10.1111/j.1365-2052.2007.01570.x

M3 - Journal article

C2 - 17302791

VL - 38

SP - 171

EP - 173

JO - Animal Genetics

JF - Animal Genetics

SN - 0268-9146

IS - 2

ER -

ID: 8073255