Exercise training reverses an age‐related attenuation in ATP signaling in human skeletal muscle
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Exercise training reverses an age‐related attenuation in ATP signaling in human skeletal muscle. / Piil, Peter; Jørgensen, Tue Smith; Egelund, Jon; Gliemann, Lasse; Hellsten, Ylva; Nyberg, Michael.
In: Translational Sports Medicine, Vol. 2, No. 5, 2019, p. 248-255.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Exercise training reverses an age‐related attenuation in ATP signaling in human skeletal muscle
AU - Piil, Peter
AU - Jørgensen, Tue Smith
AU - Egelund, Jon
AU - Gliemann, Lasse
AU - Hellsten, Ylva
AU - Nyberg, Michael
N1 - CURIS 2021 NEXS 222
PY - 2019
Y1 - 2019
N2 - The study examined the effect of 8 weeks of exercise training on ATP signaling in human skeletal muscle of 15 young (25 ± 1 years) and 15 older (72 ± 1 years) recreationally active male subjects. Before training, femoral venous plasma [ATP] was higher (P < 0.05) during low-intensity knee-extensor exercise in the older than the young group. During moderate-intensity exercise, phosphodiesterase-5 (PDE5) inhibition (to increase cGMP signaling) led to a greater increase (P < 0.05) in plasma [ATP] in the older group. The vasodilator response to arterial ATP infusion was lower (P < 0.05) in the older group. After training, plasma [ATP] was similar in the two groups during exercise at both workloads and PDE5 inhibition did not change plasma [ATP] in either group. The vasodilator response to ATP infusion was enhanced with exercise training in the older group only. These findings provide novel evidence for altered regulation of plasma [ATP] during moderate-intensity knee-extensor exercise in aging which can be reversed by exercise training. The observed effect of PDE5 inhibition suggests that altered cGMP signaling may be one underlying mechanism. Lastly, exercise training can reverse the age-related reduction in the vasodilator response to intravascular ATP.
AB - The study examined the effect of 8 weeks of exercise training on ATP signaling in human skeletal muscle of 15 young (25 ± 1 years) and 15 older (72 ± 1 years) recreationally active male subjects. Before training, femoral venous plasma [ATP] was higher (P < 0.05) during low-intensity knee-extensor exercise in the older than the young group. During moderate-intensity exercise, phosphodiesterase-5 (PDE5) inhibition (to increase cGMP signaling) led to a greater increase (P < 0.05) in plasma [ATP] in the older group. The vasodilator response to arterial ATP infusion was lower (P < 0.05) in the older group. After training, plasma [ATP] was similar in the two groups during exercise at both workloads and PDE5 inhibition did not change plasma [ATP] in either group. The vasodilator response to ATP infusion was enhanced with exercise training in the older group only. These findings provide novel evidence for altered regulation of plasma [ATP] during moderate-intensity knee-extensor exercise in aging which can be reversed by exercise training. The observed effect of PDE5 inhibition suggests that altered cGMP signaling may be one underlying mechanism. Lastly, exercise training can reverse the age-related reduction in the vasodilator response to intravascular ATP.
KW - Faculty of Science
KW - Aging
KW - Knee-extensor exercise
KW - Purinergic signaling
KW - Skeletal muscle interstitium
U2 - 10.1002/tsm2.93
DO - 10.1002/tsm2.93
M3 - Journal article
VL - 2
SP - 248
EP - 255
JO - Translational Sports Medicine
JF - Translational Sports Medicine
SN - 2573-8488
IS - 5
ER -
ID: 272714128