Dynamical and structural properties of lipid membranes in relation to liposomal drug delivery systems

Research output: Contribution to journalJournal articleResearchpeer-review

The structural and dynamical properties of DPPC liposomes containing lipopolymers (PEG-lipids) and charged DPPS lipids have been studied in relation to the lipid membrane interaction of enzymes and peptides. The results suggest that both the lipid membrane structure and dynamics and in particular the appearance of small-scale lipid structures might be of importance for the activity of membrane associated and liposome degrading enzymes as well as for the membrane interaction of acylated peptides. The combined experimental and simulation results are of relevance for a rational development of peptide loaded liposomal drug delivery systems that become destabilized by membrane degrading phospholipase A2 enzymes, which are found at elevated concentrations at diseased sites.

Original languageEnglish
JournalCellular and Molecular Biology Letters
Volume6
Issue number2 A
Pages (from-to)255-263
Number of pages9
ISSN1425-8153
Publication statusPublished - 1 Jan 2001

    Research areas

  • Acylated Peptides, Computer Simulation, Drug Delivery, Fluorescence, Lipid Domain, Lipid Membranes, PEG-Liposomes, Phase Equilibria, Phase Transition, Phospholipase A

ID: 236896835