Children with Asthma Have Fixed Airway Obstruction through Childhood Unaffected by Exacerbations

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Children with Asthma Have Fixed Airway Obstruction through Childhood Unaffected by Exacerbations. / Hallas, Henrik W.; Chawes, Bo L.; Arianto, Lambang; Rasmussen, Morten A.; Kunøe, Asja; Stokholm, Jakob; Bønnelykke, Klaus; Bisgaard, Hans.

In: Journal of Allergy and Clinical Immunology: In Practice, Vol. 8, No. 4, 2020, p. 1263-1271.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Hallas, HW, Chawes, BL, Arianto, L, Rasmussen, MA, Kunøe, A, Stokholm, J, Bønnelykke, K & Bisgaard, H 2020, 'Children with Asthma Have Fixed Airway Obstruction through Childhood Unaffected by Exacerbations', Journal of Allergy and Clinical Immunology: In Practice, vol. 8, no. 4, pp. 1263-1271. https://doi.org/10.1016/j.jaip.2019.10.031

APA

Hallas, H. W., Chawes, B. L., Arianto, L., Rasmussen, M. A., Kunøe, A., Stokholm, J., Bønnelykke, K., & Bisgaard, H. (2020). Children with Asthma Have Fixed Airway Obstruction through Childhood Unaffected by Exacerbations. Journal of Allergy and Clinical Immunology: In Practice, 8(4), 1263-1271. https://doi.org/10.1016/j.jaip.2019.10.031

Vancouver

Hallas HW, Chawes BL, Arianto L, Rasmussen MA, Kunøe A, Stokholm J et al. Children with Asthma Have Fixed Airway Obstruction through Childhood Unaffected by Exacerbations. Journal of Allergy and Clinical Immunology: In Practice. 2020;8(4):1263-1271. https://doi.org/10.1016/j.jaip.2019.10.031

Author

Hallas, Henrik W. ; Chawes, Bo L. ; Arianto, Lambang ; Rasmussen, Morten A. ; Kunøe, Asja ; Stokholm, Jakob ; Bønnelykke, Klaus ; Bisgaard, Hans. / Children with Asthma Have Fixed Airway Obstruction through Childhood Unaffected by Exacerbations. In: Journal of Allergy and Clinical Immunology: In Practice. 2020 ; Vol. 8, No. 4. pp. 1263-1271.

Bibtex

@article{ba7d743fad514cd5844731008821cb7f,
title = "Children with Asthma Have Fixed Airway Obstruction through Childhood Unaffected by Exacerbations",
abstract = "Background: Children with asthma may have a disease course with or without exacerbations, but the relationship between exacerbations and lung function development is poorly understood. Objective: To compare lung function trajectories from birth till adolescence in asthmatic children with and without exacerbations. Methods: Children with asthma from the Copenhagen Prospective Studies on Asthma in Childhood2000 (COPSAC2000) birth cohort had lung function and bronchial reactivity assessed repeatedly from 1 month to 13 years. Exacerbations were diagnosed at the COPSAC clinic defined as symptoms requiring hospitalization, oral or high-dose inhaled corticosteroid treatment. Mixed models were applied to analyze lung function trajectories. Results: Children with asthma with exacerbations (N = 50) had a trajectory of increased, fixed airway obstruction compared with children without exacerbations (N = 47): z-score difference in airway resistance (sRawz) (95% confidence interval [CI]): +0.34 (+0.03; +0.66), P = .03, and maximal mid-expiratory flow (MMEFz): −0.41 (−0.69; −0.13), P = .004, but no differences in forced expiratory volume (FEVz): −0.14 (−0.41; +0.13), P = .29, or bronchial reactivity to methacholine (PDz): +0.08 (−0.26; +0.42), P = .65. This did not change comparing lung function trajectories before and after exacerbations: z-score difference (95% CI) sRawz: −0.04 (−0.35; 0.27), P = .80; MMEFz: 0.01 (−0.02; 0.04), P = .55; FEVz: 0.02 (−0.02; 0.05), P = .42; and PDz: −0.01 (−0.06; 0.05), P = .88. Conclusion: Children with asthma with exacerbations compared with children with asthma without exacerbations are characterized by increased airway obstruction since infancy through childhood. The airway obstruction is a fixed trajectory without progression due to exacerbations, suggesting that exacerbations are a consequence rather than a cause of diminished airway caliber in childhood.",
keywords = "Asthma, Birth cohort, Bronchial reactivity, Exacerbation, Lung function",
author = "Hallas, {Henrik W.} and Chawes, {Bo L.} and Lambang Arianto and Rasmussen, {Morten A.} and Asja Kun{\o}e and Jakob Stokholm and Klaus B{\o}nnelykke and Hans Bisgaard",
year = "2020",
doi = "10.1016/j.jaip.2019.10.031",
language = "English",
volume = "8",
pages = "1263--1271",
journal = "The Journal of Allergy and Clinical Immunology: In Practice",
issn = "2213-2198",
publisher = "Elsevier",
number = "4",

}

RIS

TY - JOUR

T1 - Children with Asthma Have Fixed Airway Obstruction through Childhood Unaffected by Exacerbations

AU - Hallas, Henrik W.

AU - Chawes, Bo L.

AU - Arianto, Lambang

AU - Rasmussen, Morten A.

AU - Kunøe, Asja

AU - Stokholm, Jakob

AU - Bønnelykke, Klaus

AU - Bisgaard, Hans

PY - 2020

Y1 - 2020

N2 - Background: Children with asthma may have a disease course with or without exacerbations, but the relationship between exacerbations and lung function development is poorly understood. Objective: To compare lung function trajectories from birth till adolescence in asthmatic children with and without exacerbations. Methods: Children with asthma from the Copenhagen Prospective Studies on Asthma in Childhood2000 (COPSAC2000) birth cohort had lung function and bronchial reactivity assessed repeatedly from 1 month to 13 years. Exacerbations were diagnosed at the COPSAC clinic defined as symptoms requiring hospitalization, oral or high-dose inhaled corticosteroid treatment. Mixed models were applied to analyze lung function trajectories. Results: Children with asthma with exacerbations (N = 50) had a trajectory of increased, fixed airway obstruction compared with children without exacerbations (N = 47): z-score difference in airway resistance (sRawz) (95% confidence interval [CI]): +0.34 (+0.03; +0.66), P = .03, and maximal mid-expiratory flow (MMEFz): −0.41 (−0.69; −0.13), P = .004, but no differences in forced expiratory volume (FEVz): −0.14 (−0.41; +0.13), P = .29, or bronchial reactivity to methacholine (PDz): +0.08 (−0.26; +0.42), P = .65. This did not change comparing lung function trajectories before and after exacerbations: z-score difference (95% CI) sRawz: −0.04 (−0.35; 0.27), P = .80; MMEFz: 0.01 (−0.02; 0.04), P = .55; FEVz: 0.02 (−0.02; 0.05), P = .42; and PDz: −0.01 (−0.06; 0.05), P = .88. Conclusion: Children with asthma with exacerbations compared with children with asthma without exacerbations are characterized by increased airway obstruction since infancy through childhood. The airway obstruction is a fixed trajectory without progression due to exacerbations, suggesting that exacerbations are a consequence rather than a cause of diminished airway caliber in childhood.

AB - Background: Children with asthma may have a disease course with or without exacerbations, but the relationship between exacerbations and lung function development is poorly understood. Objective: To compare lung function trajectories from birth till adolescence in asthmatic children with and without exacerbations. Methods: Children with asthma from the Copenhagen Prospective Studies on Asthma in Childhood2000 (COPSAC2000) birth cohort had lung function and bronchial reactivity assessed repeatedly from 1 month to 13 years. Exacerbations were diagnosed at the COPSAC clinic defined as symptoms requiring hospitalization, oral or high-dose inhaled corticosteroid treatment. Mixed models were applied to analyze lung function trajectories. Results: Children with asthma with exacerbations (N = 50) had a trajectory of increased, fixed airway obstruction compared with children without exacerbations (N = 47): z-score difference in airway resistance (sRawz) (95% confidence interval [CI]): +0.34 (+0.03; +0.66), P = .03, and maximal mid-expiratory flow (MMEFz): −0.41 (−0.69; −0.13), P = .004, but no differences in forced expiratory volume (FEVz): −0.14 (−0.41; +0.13), P = .29, or bronchial reactivity to methacholine (PDz): +0.08 (−0.26; +0.42), P = .65. This did not change comparing lung function trajectories before and after exacerbations: z-score difference (95% CI) sRawz: −0.04 (−0.35; 0.27), P = .80; MMEFz: 0.01 (−0.02; 0.04), P = .55; FEVz: 0.02 (−0.02; 0.05), P = .42; and PDz: −0.01 (−0.06; 0.05), P = .88. Conclusion: Children with asthma with exacerbations compared with children with asthma without exacerbations are characterized by increased airway obstruction since infancy through childhood. The airway obstruction is a fixed trajectory without progression due to exacerbations, suggesting that exacerbations are a consequence rather than a cause of diminished airway caliber in childhood.

KW - Asthma

KW - Birth cohort

KW - Bronchial reactivity

KW - Exacerbation

KW - Lung function

U2 - 10.1016/j.jaip.2019.10.031

DO - 10.1016/j.jaip.2019.10.031

M3 - Journal article

C2 - 31707066

AN - SCOPUS:85075808496

VL - 8

SP - 1263

EP - 1271

JO - The Journal of Allergy and Clinical Immunology: In Practice

JF - The Journal of Allergy and Clinical Immunology: In Practice

SN - 2213-2198

IS - 4

ER -

ID: 234936431