Characterization of upper thoracic spinal neurons receiving noxious cardiac and/or somatic inputs in diabetic rats

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Characterization of upper thoracic spinal neurons receiving noxious cardiac and/or somatic inputs in diabetic rats. / Ghorbani, Marie Louise M; Qin, Chao; Wu, Mingyuan; Farber, Jay P; Sheykhzade, Majid; Fjalland, Bjarne; Nyborg, Niels C B; Foreman, Robert D.

In: Autonomic Neuroscience: Basic and Clinical, Vol. 165, No. 2, 07.12.2011, p. 168-177.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Ghorbani, MLM, Qin, C, Wu, M, Farber, JP, Sheykhzade, M, Fjalland, B, Nyborg, NCB & Foreman, RD 2011, 'Characterization of upper thoracic spinal neurons receiving noxious cardiac and/or somatic inputs in diabetic rats', Autonomic Neuroscience: Basic and Clinical, vol. 165, no. 2, pp. 168-177. https://doi.org/10.1016/j.autneu.2011.07.007

APA

Ghorbani, M. L. M., Qin, C., Wu, M., Farber, J. P., Sheykhzade, M., Fjalland, B., ... Foreman, R. D. (2011). Characterization of upper thoracic spinal neurons receiving noxious cardiac and/or somatic inputs in diabetic rats. Autonomic Neuroscience: Basic and Clinical, 165(2), 168-177. https://doi.org/10.1016/j.autneu.2011.07.007

Vancouver

Ghorbani MLM, Qin C, Wu M, Farber JP, Sheykhzade M, Fjalland B et al. Characterization of upper thoracic spinal neurons receiving noxious cardiac and/or somatic inputs in diabetic rats. Autonomic Neuroscience: Basic and Clinical. 2011 Dec 7;165(2):168-177. https://doi.org/10.1016/j.autneu.2011.07.007

Author

Ghorbani, Marie Louise M ; Qin, Chao ; Wu, Mingyuan ; Farber, Jay P ; Sheykhzade, Majid ; Fjalland, Bjarne ; Nyborg, Niels C B ; Foreman, Robert D. / Characterization of upper thoracic spinal neurons receiving noxious cardiac and/or somatic inputs in diabetic rats. In: Autonomic Neuroscience: Basic and Clinical. 2011 ; Vol. 165, No. 2. pp. 168-177.

Bibtex

@article{5800d13785294f2390d0fe766a9a729b,
title = "Characterization of upper thoracic spinal neurons receiving noxious cardiac and/or somatic inputs in diabetic rats",
abstract = "The aim of the present study was to examine spinal processing of cardiac and somatic nociceptive input in rats with STZ-induced diabetes. Type 1 diabetes was induced with streptozotocin (50mg/kg) in 14 male Sprague-Dawley rats and citrate buffer was injected in 14 control rats. After 4-11weeks, the rats were anesthetized with pentobarbital, ventilated and paralyzed. A laminectomy enabled extracellular recording of T(3) spinal cord neuronal activity. Intrapericardial administration of a mixture of algogenic chemicals (bradykinin, serotonin, prostaglandin E(2) (all at 10(-5)M), and adenosine (10(-3)M)) was applied to activate nociceptors of cardiac afferent nerve endings. Furthermore, somatic receptive properties were examined by applying innocuous (brush and light pressure) and noxious (pinch) cutaneous mechanical stimuli. Diabetes-induced increases in spontaneous activity were observed in subsets of neurons exhibiting long-lasting excitatory responses to administration of the algogenic mixture. Algogenic chemicals altered activity of a larger proportion of neurons from diabetic animals (73/111) than control animals (55/115, P",
keywords = "Former Faculty of Pharmaceutical Sciences",
author = "Ghorbani, {Marie Louise M} and Chao Qin and Mingyuan Wu and Farber, {Jay P} and Majid Sheykhzade and Bjarne Fjalland and Nyborg, {Niels C B} and Foreman, {Robert D}",
note = "Copyright {\circledC} 2011 Elsevier B.V. All rights reserved.",
year = "2011",
month = "12",
day = "7",
doi = "10.1016/j.autneu.2011.07.007",
language = "English",
volume = "165",
pages = "168--177",
journal = "Autonomic Neuroscience: Basic and Clinical",
issn = "1566-0702",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - Characterization of upper thoracic spinal neurons receiving noxious cardiac and/or somatic inputs in diabetic rats

AU - Ghorbani, Marie Louise M

AU - Qin, Chao

AU - Wu, Mingyuan

AU - Farber, Jay P

AU - Sheykhzade, Majid

AU - Fjalland, Bjarne

AU - Nyborg, Niels C B

AU - Foreman, Robert D

N1 - Copyright © 2011 Elsevier B.V. All rights reserved.

PY - 2011/12/7

Y1 - 2011/12/7

N2 - The aim of the present study was to examine spinal processing of cardiac and somatic nociceptive input in rats with STZ-induced diabetes. Type 1 diabetes was induced with streptozotocin (50mg/kg) in 14 male Sprague-Dawley rats and citrate buffer was injected in 14 control rats. After 4-11weeks, the rats were anesthetized with pentobarbital, ventilated and paralyzed. A laminectomy enabled extracellular recording of T(3) spinal cord neuronal activity. Intrapericardial administration of a mixture of algogenic chemicals (bradykinin, serotonin, prostaglandin E(2) (all at 10(-5)M), and adenosine (10(-3)M)) was applied to activate nociceptors of cardiac afferent nerve endings. Furthermore, somatic receptive properties were examined by applying innocuous (brush and light pressure) and noxious (pinch) cutaneous mechanical stimuli. Diabetes-induced increases in spontaneous activity were observed in subsets of neurons exhibiting long-lasting excitatory responses to administration of the algogenic mixture. Algogenic chemicals altered activity of a larger proportion of neurons from diabetic animals (73/111) than control animals (55/115, P

AB - The aim of the present study was to examine spinal processing of cardiac and somatic nociceptive input in rats with STZ-induced diabetes. Type 1 diabetes was induced with streptozotocin (50mg/kg) in 14 male Sprague-Dawley rats and citrate buffer was injected in 14 control rats. After 4-11weeks, the rats were anesthetized with pentobarbital, ventilated and paralyzed. A laminectomy enabled extracellular recording of T(3) spinal cord neuronal activity. Intrapericardial administration of a mixture of algogenic chemicals (bradykinin, serotonin, prostaglandin E(2) (all at 10(-5)M), and adenosine (10(-3)M)) was applied to activate nociceptors of cardiac afferent nerve endings. Furthermore, somatic receptive properties were examined by applying innocuous (brush and light pressure) and noxious (pinch) cutaneous mechanical stimuli. Diabetes-induced increases in spontaneous activity were observed in subsets of neurons exhibiting long-lasting excitatory responses to administration of the algogenic mixture. Algogenic chemicals altered activity of a larger proportion of neurons from diabetic animals (73/111) than control animals (55/115, P

KW - Former Faculty of Pharmaceutical Sciences

U2 - 10.1016/j.autneu.2011.07.007

DO - 10.1016/j.autneu.2011.07.007

M3 - Journal article

C2 - 21862419

VL - 165

SP - 168

EP - 177

JO - Autonomic Neuroscience: Basic and Clinical

JF - Autonomic Neuroscience: Basic and Clinical

SN - 1566-0702

IS - 2

ER -

ID: 33968861