Characterization of Fluorinated Catansomes: A Promising Vector in Drug-Delivery

Research output: Contribution to journalJournal articlepeer-review

Standard

Characterization of Fluorinated Catansomes : A Promising Vector in Drug-Delivery. / Rosholm, Kadla R.; Arouri, Ahmad; Hansen, Per L.; González-Pérez, Alfredo; Mouritsen, Ole G.

In: Langmuir, Vol. 28, No. 5, 2012, p. 2773-2781.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Rosholm, KR, Arouri, A, Hansen, PL, González-Pérez, A & Mouritsen, OG 2012, 'Characterization of Fluorinated Catansomes: A Promising Vector in Drug-Delivery', Langmuir, vol. 28, no. 5, pp. 2773-2781. https://doi.org/10.1021/la2039834

APA

Rosholm, K. R., Arouri, A., Hansen, P. L., González-Pérez, A., & Mouritsen, O. G. (2012). Characterization of Fluorinated Catansomes: A Promising Vector in Drug-Delivery. Langmuir, 28(5), 2773-2781. https://doi.org/10.1021/la2039834

Vancouver

Rosholm KR, Arouri A, Hansen PL, González-Pérez A, Mouritsen OG. Characterization of Fluorinated Catansomes: A Promising Vector in Drug-Delivery. Langmuir. 2012;28(5):2773-2781. https://doi.org/10.1021/la2039834

Author

Rosholm, Kadla R. ; Arouri, Ahmad ; Hansen, Per L. ; González-Pérez, Alfredo ; Mouritsen, Ole G. / Characterization of Fluorinated Catansomes : A Promising Vector in Drug-Delivery. In: Langmuir. 2012 ; Vol. 28, No. 5. pp. 2773-2781.

Bibtex

@article{f3c25edb0c6847eda07591fe2895e927,
title = "Characterization of Fluorinated Catansomes: A Promising Vector in Drug-Delivery",
abstract = "Catansomes, which are vesicles prepared from mixtures of oppositely charged surfactants, have been suggested as effective alternatives to phospholipid vesicles, i.e., liposomes, in applications such as drug-delivery. This is mainly due to their enhanced chemical and physical stability as well as to their relatively easy preparation, which is an advantage for large-scale productions. In this study we have investigated catansomes prepared from a perfluorinated anionic surfactant (sodium perfluorooctanoate) premixed with a hydrogenated cationic surfactant (dodecyltrimethylammonium bromide or 1-dodecylpyridinium chloride). The aim was to gain insights into the physicochemical properties of these systems, such as size, stability, surface charge, and membrane morphology, which are essential for their use in drug-delivery applications. The catansomes were mostly unilamellar and 100-200 nm in size, and were stable for more than five months at room temperature. After loading the catansomes with the fluorescent marker calcein, they were found to exhibit an appreciable encapsulation efficiency and a low calcein leakage over time. The addition of fatty acids to calcein-loaded catansomes considerably promoted the release of calcein, and the rate and efficiency of calcein release were found to be proportional to the fatty acid concentration and chain length. Our results prove the feasibility of utilizing catansomes as drug-delivery vehicles as well as provide a means to efficiently release the encapsulated load.",
author = "Rosholm, {Kadla R.} and Ahmad Arouri and Hansen, {Per L.} and Alfredo Gonz{\'a}lez-P{\'e}rez and Mouritsen, {Ole G.}",
year = "2012",
doi = "10.1021/la2039834",
language = "English",
volume = "28",
pages = "2773--2781",
journal = "Langmuir",
issn = "0743-7463",
publisher = "American Chemical Society",
number = "5",

}

RIS

TY - JOUR

T1 - Characterization of Fluorinated Catansomes

T2 - A Promising Vector in Drug-Delivery

AU - Rosholm, Kadla R.

AU - Arouri, Ahmad

AU - Hansen, Per L.

AU - González-Pérez, Alfredo

AU - Mouritsen, Ole G.

PY - 2012

Y1 - 2012

N2 - Catansomes, which are vesicles prepared from mixtures of oppositely charged surfactants, have been suggested as effective alternatives to phospholipid vesicles, i.e., liposomes, in applications such as drug-delivery. This is mainly due to their enhanced chemical and physical stability as well as to their relatively easy preparation, which is an advantage for large-scale productions. In this study we have investigated catansomes prepared from a perfluorinated anionic surfactant (sodium perfluorooctanoate) premixed with a hydrogenated cationic surfactant (dodecyltrimethylammonium bromide or 1-dodecylpyridinium chloride). The aim was to gain insights into the physicochemical properties of these systems, such as size, stability, surface charge, and membrane morphology, which are essential for their use in drug-delivery applications. The catansomes were mostly unilamellar and 100-200 nm in size, and were stable for more than five months at room temperature. After loading the catansomes with the fluorescent marker calcein, they were found to exhibit an appreciable encapsulation efficiency and a low calcein leakage over time. The addition of fatty acids to calcein-loaded catansomes considerably promoted the release of calcein, and the rate and efficiency of calcein release were found to be proportional to the fatty acid concentration and chain length. Our results prove the feasibility of utilizing catansomes as drug-delivery vehicles as well as provide a means to efficiently release the encapsulated load.

AB - Catansomes, which are vesicles prepared from mixtures of oppositely charged surfactants, have been suggested as effective alternatives to phospholipid vesicles, i.e., liposomes, in applications such as drug-delivery. This is mainly due to their enhanced chemical and physical stability as well as to their relatively easy preparation, which is an advantage for large-scale productions. In this study we have investigated catansomes prepared from a perfluorinated anionic surfactant (sodium perfluorooctanoate) premixed with a hydrogenated cationic surfactant (dodecyltrimethylammonium bromide or 1-dodecylpyridinium chloride). The aim was to gain insights into the physicochemical properties of these systems, such as size, stability, surface charge, and membrane morphology, which are essential for their use in drug-delivery applications. The catansomes were mostly unilamellar and 100-200 nm in size, and were stable for more than five months at room temperature. After loading the catansomes with the fluorescent marker calcein, they were found to exhibit an appreciable encapsulation efficiency and a low calcein leakage over time. The addition of fatty acids to calcein-loaded catansomes considerably promoted the release of calcein, and the rate and efficiency of calcein release were found to be proportional to the fatty acid concentration and chain length. Our results prove the feasibility of utilizing catansomes as drug-delivery vehicles as well as provide a means to efficiently release the encapsulated load.

U2 - 10.1021/la2039834

DO - 10.1021/la2039834

M3 - Journal article

C2 - 22149538

AN - SCOPUS:84856755965

VL - 28

SP - 2773

EP - 2781

JO - Langmuir

JF - Langmuir

SN - 0743-7463

IS - 5

ER -

ID: 230975375