Beyond genetics. Influence of dietary factors and gut microbiota on type 1 diabetes

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Beyond genetics. Influence of dietary factors and gut microbiota on type 1 diabetes. / Nielsen, Dennis Sandris; Krych, Lukasz; Buschard, Karsten; Hansen, Camilla Hartmann Friis; Hansen, Axel Jacob Kornerup.

In: FEBS letters, Vol. 588, No. 22, 2014, p. 4234-4243.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Nielsen, DS, Krych, L, Buschard, K, Hansen, CHF & Hansen, AJK 2014, 'Beyond genetics. Influence of dietary factors and gut microbiota on type 1 diabetes', FEBS letters, vol. 588, no. 22, pp. 4234-4243. https://doi.org/10.1016/j.febslet.2014.04.010

APA

Nielsen, D. S., Krych, L., Buschard, K., Hansen, C. H. F., & Hansen, A. J. K. (2014). Beyond genetics. Influence of dietary factors and gut microbiota on type 1 diabetes. FEBS letters, 588(22), 4234-4243. https://doi.org/10.1016/j.febslet.2014.04.010

Vancouver

Nielsen DS, Krych L, Buschard K, Hansen CHF, Hansen AJK. Beyond genetics. Influence of dietary factors and gut microbiota on type 1 diabetes. FEBS letters. 2014;588(22):4234-4243. https://doi.org/10.1016/j.febslet.2014.04.010

Author

Nielsen, Dennis Sandris ; Krych, Lukasz ; Buschard, Karsten ; Hansen, Camilla Hartmann Friis ; Hansen, Axel Jacob Kornerup. / Beyond genetics. Influence of dietary factors and gut microbiota on type 1 diabetes. In: FEBS letters. 2014 ; Vol. 588, No. 22. pp. 4234-4243.

Bibtex

@article{2983aa1c45844ffa929b70f810e9655a,
title = "Beyond genetics. Influence of dietary factors and gut microbiota on type 1 diabetes",
abstract = "Type 1 diabetes (T1D) is an autoimmune disease ultimately leading to destruction of insulin secreting β-cells in the pancreas. Genetic susceptibility plays an important role in T1D etiology, but even mono-zygotic twins only have a concordance rate of around 50{\%}, underlining that other factors than purely genetic are involved in disease development. Here we review the influence of dietary and environmental factors on T1D development in humans as well as animal models. Even though data are still inconclusive, there are strong indications that gut microbiota dysbiosis plays an important role in T1D development and evidence from animal models suggests that gut microbiota manipulation might prove valuable in future prevention of T1D in genetically susceptible individuals.",
author = "Nielsen, {Dennis Sandris} and Lukasz Krych and Karsten Buschard and Hansen, {Camilla Hartmann Friis} and Hansen, {Axel Jacob Kornerup}",
note = "Copyright {\circledC} 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.",
year = "2014",
doi = "10.1016/j.febslet.2014.04.010",
language = "English",
volume = "588",
pages = "4234--4243",
journal = "F E B S Letters",
issn = "0014-5793",
publisher = "JohnWiley & Sons Ltd",
number = "22",

}

RIS

TY - JOUR

T1 - Beyond genetics. Influence of dietary factors and gut microbiota on type 1 diabetes

AU - Nielsen, Dennis Sandris

AU - Krych, Lukasz

AU - Buschard, Karsten

AU - Hansen, Camilla Hartmann Friis

AU - Hansen, Axel Jacob Kornerup

N1 - Copyright © 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

PY - 2014

Y1 - 2014

N2 - Type 1 diabetes (T1D) is an autoimmune disease ultimately leading to destruction of insulin secreting β-cells in the pancreas. Genetic susceptibility plays an important role in T1D etiology, but even mono-zygotic twins only have a concordance rate of around 50%, underlining that other factors than purely genetic are involved in disease development. Here we review the influence of dietary and environmental factors on T1D development in humans as well as animal models. Even though data are still inconclusive, there are strong indications that gut microbiota dysbiosis plays an important role in T1D development and evidence from animal models suggests that gut microbiota manipulation might prove valuable in future prevention of T1D in genetically susceptible individuals.

AB - Type 1 diabetes (T1D) is an autoimmune disease ultimately leading to destruction of insulin secreting β-cells in the pancreas. Genetic susceptibility plays an important role in T1D etiology, but even mono-zygotic twins only have a concordance rate of around 50%, underlining that other factors than purely genetic are involved in disease development. Here we review the influence of dietary and environmental factors on T1D development in humans as well as animal models. Even though data are still inconclusive, there are strong indications that gut microbiota dysbiosis plays an important role in T1D development and evidence from animal models suggests that gut microbiota manipulation might prove valuable in future prevention of T1D in genetically susceptible individuals.

U2 - 10.1016/j.febslet.2014.04.010

DO - 10.1016/j.febslet.2014.04.010

M3 - Journal article

VL - 588

SP - 4234

EP - 4243

JO - F E B S Letters

JF - F E B S Letters

SN - 0014-5793

IS - 22

ER -

ID: 125786466