A new look at lipid-membrane structure in relation to drug research

Research output: Contribution to journalReviewResearchpeer-review

  • Ole G. Mouritsen
  • Kent Jørgensen

Lipid-bilayer membranes are key objects in drug research in relation to (i) interaction of drugs with membrane-bound receptors, (ii) drug targeting, penetration, and permeation of cell membranes, and (iii) use of liposomes in micro-encapsulation technologies for drug delivery. Rational design of new drugs and drug-delivery systems therefore requires insight into the physical properties of lipid-bilayer membranes. This mini-review provides a perspective on the current view of lipid-bilayer structure and dynamics based on information obtained from a variety of recent experimental and theoretical studies. Special attention is paid to trans-bilayer structure, lateral molecular organization of the lipid bilayer, lipid-mediated protein assembly and lipid-bilayer permeability. It is argued that lipids play a major role in lipid membrane-organization and functionality.

Original languageEnglish
JournalPharmaceutical Research
Volume15
Issue number10
Pages (from-to)1507-1519
Number of pages13
ISSN0724-8741
DOIs
Publication statusPublished - 21 Oct 1998

    Research areas

  • Lipid bilayer, Lipid-protein interaction, Molecular organization, Permeability, Phase transitions

ID: 236886687