A microscopic model for lipid/protein bilayers with critical mixing

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Standard

A microscopic model for lipid/protein bilayers with critical mixing. / Zhang, Zhengping; Sperotto, Maria M.; Zuckermann, Martin J.; Mouritsen, Ole G.

In: Biochimica et Biophysica Acta - Biomembranes, Vol. 1147, No. 1, 1993, p. 154-160.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Zhang, Z, Sperotto, MM, Zuckermann, MJ & Mouritsen, OG 1993, 'A microscopic model for lipid/protein bilayers with critical mixing', Biochimica et Biophysica Acta - Biomembranes, vol. 1147, no. 1, pp. 154-160. https://doi.org/10.1016/0005-2736(93)90326-U

APA

Zhang, Z., Sperotto, M. M., Zuckermann, M. J., & Mouritsen, O. G. (1993). A microscopic model for lipid/protein bilayers with critical mixing. Biochimica et Biophysica Acta - Biomembranes, 1147(1), 154-160. https://doi.org/10.1016/0005-2736(93)90326-U

Vancouver

Zhang Z, Sperotto MM, Zuckermann MJ, Mouritsen OG. A microscopic model for lipid/protein bilayers with critical mixing. Biochimica et Biophysica Acta - Biomembranes. 1993;1147(1):154-160. https://doi.org/10.1016/0005-2736(93)90326-U

Author

Zhang, Zhengping ; Sperotto, Maria M. ; Zuckermann, Martin J. ; Mouritsen, Ole G. / A microscopic model for lipid/protein bilayers with critical mixing. In: Biochimica et Biophysica Acta - Biomembranes. 1993 ; Vol. 1147, No. 1. pp. 154-160.

Bibtex

@article{3c765814a16d40138397ed48c3e93a36,
title = "A microscopic model for lipid/protein bilayers with critical mixing",
abstract = "A statistical mechanical lattice model is proposed to describe the phase diagram of phospholipid bilayers with small transmembrane proteins or polypeptides. The model is based on the extended Pink-Green-Chapman model (Zhang et al. (1992) Phys. Rev. A 45, 7560-7567) for pure lipid bilayers which undergo a first-order gel-fluid phase transition. The interaction between the lipid bilayer and the protein or polypeptide is modelled using the concept of hydrophobic matching. The phase diagram has been derived by computer-simulation techniques which fully account for thermal density fluctuations and which operate on the level of the free-energy thereby permitting an accurate identification of the phase boundaries. The calculations predict a closed loop of gel-fluid coexistence with a lower critical mixing point. Specific-heat traces across the phase diagram are also presented. The theoretical results for the phase diagram, the specific-heat function, and the transition enthalpy are related to recent experimental measurements on phospholipid bilayers mixed with synthetic transmembrane amphiphilic polypeptides or with gramicidin A.",
keywords = "Critical mixing, Gramicidin A, Lipid bilayer, Phase diagram, Polypeptide",
author = "Zhengping Zhang and Sperotto, {Maria M.} and Zuckermann, {Martin J.} and Mouritsen, {Ole G.}",
year = "1993",
doi = "10.1016/0005-2736(93)90326-U",
language = "English",
volume = "1147",
pages = "154--160",
journal = "B B A - Biomembranes",
issn = "0005-2736",
publisher = "Elsevier",
number = "1",

}

RIS

TY - JOUR

T1 - A microscopic model for lipid/protein bilayers with critical mixing

AU - Zhang, Zhengping

AU - Sperotto, Maria M.

AU - Zuckermann, Martin J.

AU - Mouritsen, Ole G.

PY - 1993

Y1 - 1993

N2 - A statistical mechanical lattice model is proposed to describe the phase diagram of phospholipid bilayers with small transmembrane proteins or polypeptides. The model is based on the extended Pink-Green-Chapman model (Zhang et al. (1992) Phys. Rev. A 45, 7560-7567) for pure lipid bilayers which undergo a first-order gel-fluid phase transition. The interaction between the lipid bilayer and the protein or polypeptide is modelled using the concept of hydrophobic matching. The phase diagram has been derived by computer-simulation techniques which fully account for thermal density fluctuations and which operate on the level of the free-energy thereby permitting an accurate identification of the phase boundaries. The calculations predict a closed loop of gel-fluid coexistence with a lower critical mixing point. Specific-heat traces across the phase diagram are also presented. The theoretical results for the phase diagram, the specific-heat function, and the transition enthalpy are related to recent experimental measurements on phospholipid bilayers mixed with synthetic transmembrane amphiphilic polypeptides or with gramicidin A.

AB - A statistical mechanical lattice model is proposed to describe the phase diagram of phospholipid bilayers with small transmembrane proteins or polypeptides. The model is based on the extended Pink-Green-Chapman model (Zhang et al. (1992) Phys. Rev. A 45, 7560-7567) for pure lipid bilayers which undergo a first-order gel-fluid phase transition. The interaction between the lipid bilayer and the protein or polypeptide is modelled using the concept of hydrophobic matching. The phase diagram has been derived by computer-simulation techniques which fully account for thermal density fluctuations and which operate on the level of the free-energy thereby permitting an accurate identification of the phase boundaries. The calculations predict a closed loop of gel-fluid coexistence with a lower critical mixing point. Specific-heat traces across the phase diagram are also presented. The theoretical results for the phase diagram, the specific-heat function, and the transition enthalpy are related to recent experimental measurements on phospholipid bilayers mixed with synthetic transmembrane amphiphilic polypeptides or with gramicidin A.

KW - Critical mixing

KW - Gramicidin A

KW - Lipid bilayer

KW - Phase diagram

KW - Polypeptide

U2 - 10.1016/0005-2736(93)90326-U

DO - 10.1016/0005-2736(93)90326-U

M3 - Journal article

C2 - 8466927

AN - SCOPUS:0027477887

VL - 1147

SP - 154

EP - 160

JO - B B A - Biomembranes

JF - B B A - Biomembranes

SN - 0005-2736

IS - 1

ER -

ID: 236891026