TY - JOUR

T1 - 1–2 drinks per day affect lipoprotein composition after 3 weeks — Results from a cross-over pilot intervention trial in healthy adults using nuclear magnetic resonance-measured lipoproteins and apolipoproteins

AU - Wilkens, Trine Levring

AU - Ziegler, Zabrina

AU - Aru, Violetta

AU - Khakimov, Bekzod

AU - Overgaard, Snædís Lilja

AU - Engelsen, Søren Balling

AU - Dragsted, Lars Ove

N1 - CURIS 2022 NEXS 285

PY - 2022

Y1 - 2022

N2 - Alcohol consumption ranging from 1–2 drinks/day associates with a lower risk of coronary heart disease in some studies. The underlying mechanisms are unclear. The Metabolic Imprints of Alcoholic Beverages (MetAl) trial aimed to explore the short-term effects of moderate alcohol consumption on cardiovascular biomarkers. A 2 × 3-week cross-over single-blinded interventiontrial investigating the effect of 1–2 drinks/day (~12–24 g) compared with abstention on 1H Nuclear Magnetic Resonance-measured main lipoproteins and subfractions was performed in 26 healthy adults. Volunteers were classified as occasional or habitual drinkers based on their habitual alcohol intakes (<2 or ≥2 drinks/week). Compared with abstention, 1–2 drinks/day increased HDL2a-C(p = 0.004), HDL3 -C (p = 0.008), and HDL non-significantly (p = 0.19). Total apoA1 and apoA1 in HDL and its subfractions increased (p < 0.05). Novel findings were a decreased apoB/apoA1 ratio (p = 0.02), and increased HDL2a phospholipid content (p = 0.04). In women alone, the results were similar but attenuated, and LDL-P decreased. Thus, changes in apoA1- and HDL-related biomarkers occur within weeks in moderate drinkers. Compared with abstention, 1–2 drinks/day increased total apoA1 more strongly than HDL-C and increased the cholesterol, apoA1, and phospholipid content of several HDL subfractions. Whether this provides a cardiovascular benefit requires further study.Clinicaltrials.gov: NCT03384147.

AB - Alcohol consumption ranging from 1–2 drinks/day associates with a lower risk of coronary heart disease in some studies. The underlying mechanisms are unclear. The Metabolic Imprints of Alcoholic Beverages (MetAl) trial aimed to explore the short-term effects of moderate alcohol consumption on cardiovascular biomarkers. A 2 × 3-week cross-over single-blinded interventiontrial investigating the effect of 1–2 drinks/day (~12–24 g) compared with abstention on 1H Nuclear Magnetic Resonance-measured main lipoproteins and subfractions was performed in 26 healthy adults. Volunteers were classified as occasional or habitual drinkers based on their habitual alcohol intakes (<2 or ≥2 drinks/week). Compared with abstention, 1–2 drinks/day increased HDL2a-C(p = 0.004), HDL3 -C (p = 0.008), and HDL non-significantly (p = 0.19). Total apoA1 and apoA1 in HDL and its subfractions increased (p < 0.05). Novel findings were a decreased apoB/apoA1 ratio (p = 0.02), and increased HDL2a phospholipid content (p = 0.04). In women alone, the results were similar but attenuated, and LDL-P decreased. Thus, changes in apoA1- and HDL-related biomarkers occur within weeks in moderate drinkers. Compared with abstention, 1–2 drinks/day increased total apoA1 more strongly than HDL-C and increased the cholesterol, apoA1, and phospholipid content of several HDL subfractions. Whether this provides a cardiovascular benefit requires further study.Clinicaltrials.gov: NCT03384147.

KW - Faculty of Science

KW - HDL

KW - ApoA1

KW - ApoB

KW - Moderate Alcohol Consumption

KW - Cardiovascular disease

KW - NMR

U2 - 10.3390/nu14235043

DO - 10.3390/nu14235043

M3 - Journal article

C2 - 36501072

VL - 14

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 23

M1 - 5043

ER -