Supplementation With Fish Oil in Pregnancy Reduces Gastroenteritis in Early Childhood
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Supplementation With Fish Oil in Pregnancy Reduces Gastroenteritis in Early Childhood. / Horner, David; Hjelmsø, Mathis Hjort; Thorsen, Jonathan; Rasmussen, Morten; Eliasen, Anders; Vinding, Rebecca Kofod; Schoos, Ann-Marie Malby; Brustad, Nicklas; Sunde, Rikke Bjersand; Bønnelykke, Klaus; Chawes, Bo L.; Stokholm, Jakob; Bisgaard, Hans.
I: Journal of Infectious Diseases, Bind 227, Nr. 3, 2023, s. 448–456.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Supplementation With Fish Oil in Pregnancy Reduces Gastroenteritis in Early Childhood
AU - Horner, David
AU - Hjelmsø, Mathis Hjort
AU - Thorsen, Jonathan
AU - Rasmussen, Morten
AU - Eliasen, Anders
AU - Vinding, Rebecca Kofod
AU - Schoos, Ann-Marie Malby
AU - Brustad, Nicklas
AU - Sunde, Rikke Bjersand
AU - Bønnelykke, Klaus
AU - Chawes, Bo L.
AU - Stokholm, Jakob
AU - Bisgaard, Hans
PY - 2023
Y1 - 2023
N2 - Background We hypothesized that insufficient intake of fish oil-derived omega-3 long-chain polyunsaturated fatty acids (n-3 LCPUFAs) during pregnancy is a contributing factor to gastroenteritis in early childhood. We examined the effect of n-3 LCPUFA supplementation on gastroenteritis symptoms in the offspring's first 3 years of life. Methods This was a double-blinded, randomized controlled trial whereby 736 mothers were administered n-3 LCPUFA or control from pregnancy week 24 until 1 week after birth. We measured the number of days with gastroenteritis, number of episodes with gastroenteritis, and the risk of having a gastroenteritis episode in the first 3 years of life. Results A median reduction of 2.5 days with gastroenteritis (P = .018) was shown, corresponding to a 14% reduction in the n-3 LCPUFA group compared with controls in the first 3 years of life (P = .037). A reduction in the number of gastroenteritis episodes (P = .027) and a reduced risk of having an episode (hazard ratio, 0.80 [95% confidence interval, .66-.97]; P = .023) were also shown. Conclusions Fish oil supplementation from the 24th week of pregnancy led to a reduction in the number of days and episodes with gastroenteritis symptoms in the first 3 years of life. The findings suggest n-3 LCPUFA supplementation as a preventive measure against gastrointestinal infections in early childhood.Supplementation with fish oil from the 24th week of pregnancy in a cohort of 736 mothers and their children resulted in fewer gastroenteritis days and episodes in the children's first 3 years of life.
AB - Background We hypothesized that insufficient intake of fish oil-derived omega-3 long-chain polyunsaturated fatty acids (n-3 LCPUFAs) during pregnancy is a contributing factor to gastroenteritis in early childhood. We examined the effect of n-3 LCPUFA supplementation on gastroenteritis symptoms in the offspring's first 3 years of life. Methods This was a double-blinded, randomized controlled trial whereby 736 mothers were administered n-3 LCPUFA or control from pregnancy week 24 until 1 week after birth. We measured the number of days with gastroenteritis, number of episodes with gastroenteritis, and the risk of having a gastroenteritis episode in the first 3 years of life. Results A median reduction of 2.5 days with gastroenteritis (P = .018) was shown, corresponding to a 14% reduction in the n-3 LCPUFA group compared with controls in the first 3 years of life (P = .037). A reduction in the number of gastroenteritis episodes (P = .027) and a reduced risk of having an episode (hazard ratio, 0.80 [95% confidence interval, .66-.97]; P = .023) were also shown. Conclusions Fish oil supplementation from the 24th week of pregnancy led to a reduction in the number of days and episodes with gastroenteritis symptoms in the first 3 years of life. The findings suggest n-3 LCPUFA supplementation as a preventive measure against gastrointestinal infections in early childhood.Supplementation with fish oil from the 24th week of pregnancy in a cohort of 736 mothers and their children resulted in fewer gastroenteritis days and episodes in the children's first 3 years of life.
KW - fish oil
KW - gastroenteritis
KW - pediatrics
KW - pregnancy supplementation
U2 - 10.1093/infdis/jiab607
DO - 10.1093/infdis/jiab607
M3 - Journal article
C2 - 34927195
VL - 227
SP - 448
EP - 456
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 3
ER -
ID: 300068293