Propionylated high-amylose maize starch alleviates obesity by modulating gut microbiota in high-fat diet-fed mice

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Propionylated high-amylose maize starch alleviates obesity by modulating gut microbiota in high-fat diet-fed mice. / Xie, Zhuqing; Yao, Minghua; Castro-Mejía, Josué L.; Ma, Ming; Zhu, Yuyan; Fu, Xiong; Huang, Qiang; Zhang, Bin.

In: Journal of Functional Foods, Vol. 102, 105447, 2023.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Xie, Z, Yao, M, Castro-Mejía, JL, Ma, M, Zhu, Y, Fu, X, Huang, Q & Zhang, B 2023, 'Propionylated high-amylose maize starch alleviates obesity by modulating gut microbiota in high-fat diet-fed mice', Journal of Functional Foods, vol. 102, 105447. https://doi.org/10.1016/j.jff.2023.105447

APA

Xie, Z., Yao, M., Castro-Mejía, J. L., Ma, M., Zhu, Y., Fu, X., Huang, Q., & Zhang, B. (2023). Propionylated high-amylose maize starch alleviates obesity by modulating gut microbiota in high-fat diet-fed mice. Journal of Functional Foods, 102, [105447]. https://doi.org/10.1016/j.jff.2023.105447

Vancouver

Xie Z, Yao M, Castro-Mejía JL, Ma M, Zhu Y, Fu X et al. Propionylated high-amylose maize starch alleviates obesity by modulating gut microbiota in high-fat diet-fed mice. Journal of Functional Foods. 2023;102. 105447. https://doi.org/10.1016/j.jff.2023.105447

Author

Xie, Zhuqing ; Yao, Minghua ; Castro-Mejía, Josué L. ; Ma, Ming ; Zhu, Yuyan ; Fu, Xiong ; Huang, Qiang ; Zhang, Bin. / Propionylated high-amylose maize starch alleviates obesity by modulating gut microbiota in high-fat diet-fed mice. In: Journal of Functional Foods. 2023 ; Vol. 102.

Bibtex

@article{e5b069fb23ae48d19ce947e3916f8a27,
title = "Propionylated high-amylose maize starch alleviates obesity by modulating gut microbiota in high-fat diet-fed mice",
abstract = "Obesity threatens human health worldwide, and mounting findings have found that gut microbiota (GM) changes induced by diet intervention influence its development. This study aims to investigate the anti-obesity effects and GM changes of propionylated high-amylose maize starch (PS) in C57BL/6J mice fed with high-fat diet (HFD). In our results, PS decreased the body weight of HFD-fed mice after 8 weeks and regulated the glucose stability and insulin resistance. High-amylose maize starch (HAMS) and PS regulated the serum lipid levels and inflammatory response. Moreover, PS yielded more propionate relative to HAMS, proving that introduced propionyl groups could be released in the colon. 16S rRNA results showed that PS altered GM with the increase of bacteria (S24-7 and Ruminococcus) and decrease of harmful genera, which is linked to the anti-obesity effect. Our results provide a reference for the design of functional dietary fibers inducing high propionate production and GM modulation.",
keywords = "Gut microbiota, High-fat diet, Propionate, Propionylated high-amylose maize starch",
author = "Zhuqing Xie and Minghua Yao and Castro-Mej{\'i}a, {Josu{\'e} L.} and Ming Ma and Yuyan Zhu and Xiong Fu and Qiang Huang and Bin Zhang",
note = "Publisher Copyright: {\textcopyright} 2023 The Author(s)",
year = "2023",
doi = "10.1016/j.jff.2023.105447",
language = "English",
volume = "102",
journal = "Journal of Functional Foods",
issn = "1756-4646",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Propionylated high-amylose maize starch alleviates obesity by modulating gut microbiota in high-fat diet-fed mice

AU - Xie, Zhuqing

AU - Yao, Minghua

AU - Castro-Mejía, Josué L.

AU - Ma, Ming

AU - Zhu, Yuyan

AU - Fu, Xiong

AU - Huang, Qiang

AU - Zhang, Bin

N1 - Publisher Copyright: © 2023 The Author(s)

PY - 2023

Y1 - 2023

N2 - Obesity threatens human health worldwide, and mounting findings have found that gut microbiota (GM) changes induced by diet intervention influence its development. This study aims to investigate the anti-obesity effects and GM changes of propionylated high-amylose maize starch (PS) in C57BL/6J mice fed with high-fat diet (HFD). In our results, PS decreased the body weight of HFD-fed mice after 8 weeks and regulated the glucose stability and insulin resistance. High-amylose maize starch (HAMS) and PS regulated the serum lipid levels and inflammatory response. Moreover, PS yielded more propionate relative to HAMS, proving that introduced propionyl groups could be released in the colon. 16S rRNA results showed that PS altered GM with the increase of bacteria (S24-7 and Ruminococcus) and decrease of harmful genera, which is linked to the anti-obesity effect. Our results provide a reference for the design of functional dietary fibers inducing high propionate production and GM modulation.

AB - Obesity threatens human health worldwide, and mounting findings have found that gut microbiota (GM) changes induced by diet intervention influence its development. This study aims to investigate the anti-obesity effects and GM changes of propionylated high-amylose maize starch (PS) in C57BL/6J mice fed with high-fat diet (HFD). In our results, PS decreased the body weight of HFD-fed mice after 8 weeks and regulated the glucose stability and insulin resistance. High-amylose maize starch (HAMS) and PS regulated the serum lipid levels and inflammatory response. Moreover, PS yielded more propionate relative to HAMS, proving that introduced propionyl groups could be released in the colon. 16S rRNA results showed that PS altered GM with the increase of bacteria (S24-7 and Ruminococcus) and decrease of harmful genera, which is linked to the anti-obesity effect. Our results provide a reference for the design of functional dietary fibers inducing high propionate production and GM modulation.

KW - Gut microbiota

KW - High-fat diet

KW - Propionate

KW - Propionylated high-amylose maize starch

U2 - 10.1016/j.jff.2023.105447

DO - 10.1016/j.jff.2023.105447

M3 - Journal article

AN - SCOPUS:85147885900

VL - 102

JO - Journal of Functional Foods

JF - Journal of Functional Foods

SN - 1756-4646

M1 - 105447

ER -

ID: 339851349