Research areas

  1. Published

    Isolation of the MAO-inhibitor naringenin from Mentha aquatica L

    Olsen, H. T., Stafford, G. I., van Staden, J., Christensen, Søren Brøgger & Jäger, A. K., 2008, In: Journal of Ethnopharmacology. 117, 3, p. 500-502

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Toltrazuril and its two main metabolites in the environment - Analytical development

    Olsen, J., Hansen, M., Krogh, K. A., Bak, S. A., Brandt, A. & Björklund, E., 2011.

    Research output: Contribution to conferencePosterResearch

  3. Published

    Studies on the metabolism of tolmetin to the chemically reactive acyl-coenzyme a thioester intermediate in rats

    Olsen, J., Li, C., Skonberg, C., Bjørnsdottir, I., Sidenius, U., Benet, L. Z. & Hansen, S. H., 2007, In: Drug Metabolism and Disposition. 35, 5, p. 758-764

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Determination of leukocyte DNA 6-thioguanine nucleotide levels by high-performance liquid chromatography with fluorescence detection

    Olsen, K., Hansen, S. H., Sidenius, U. & Schmiegelow, Kjeld, 2008, In: Journal of Chromatography - B. 864, 1-2, p. 149-155

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Prediction of activation energies for hydrogen abstraction by cytochrome p450

    Olsen, L., Rydberg, P., Rod, T. H. & Ryde, U., 2006, In: Journal of Medicinal Chemistry. 49, 22, p. 6489-6499

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Hvad har varme at gøre med lægemidler?

    Olsen, L., Kasper, C., Kastrup, Jette Sandholm Jensen, Gajhede, Michael & Jørgensen, Flemming Steen, 2006, In: Lægemiddelforskning. p. 31-33

    Research output: Contribution to journalJournal articleCommunication

  7. Published

    Cytochrome P450 Mediated Drug Metabolism

    Olsen, L., Jørgensen, Flemming Steen & Oostenbrink, C., 2016, New Horizons in Predictive Drug Metabolism and Pharmacokinetics. Wilson, A. G. E. (ed.). Cambridge: Royal Society of Chemistry, p. 66-78 13 p. (RSC Drug Discovery, Vol. 49).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  8. Published

    Constituents in kava extracts potentially involved in hepatotoxicity: A review

    Olsen, L. R., Grillo, M. P. & Skonberg, C., 2011, In: Chemical Research in Toxicology. 24, p. 992-1002

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Affinity and translocation relationships via hPEPT1 of H-Xaa-Ser-OH dipeptides: evaluation of H-Phe-Ser-OH as a pro-moiety for ibuprofen and benzoic acid prodrugs

    Omkvist, D. H., Trangbæk, D. J., Mildon, J., Paine, J. S., Larsen, Birger Brodin, Begtrup, M. & Nielsen, C. U., 2011, In: European Journal of Pharmaceutics and Biopharmaceutics. 77, 2, p. 327-331

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    A quantitative structure-activity relationship for translocation of tripeptides via the human proton-coupled peptide transporter, hPEPT1 (SLC15A1)

    Omkvist, D. H., Larsen, S. B., Nielsen, C. U., Steffansen, B., Olsen, L., Jørgensen, Flemming Steen & Larsen, Birger Brodin, 2010, In: The AAPS Journal. 12, 3, p. 385-396

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Ibuprofen is a non-competitive inhibitor of the peptide transporter hPEPT1 (SLC15A1): possible interactions between hPEPT1 substrates and ibuprofen

    Omkvist, D. H., Larsen, Birger Brodin & Nielsen, C. U., 2010, In: British Journal of Pharmacology. 161, 8, p. 1793-1805

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Ibuprofen is an inhibitor of hPEPT1: Implications for drug-drug interactions at the level of drug absorption

    Omkvist, D. H., Larsen, Birger Brodin & Nielsen, C. U., 2010.

    Research output: Contribution to conferencePosterResearch

  13. Published

    Intestinal drug delivery via hPEPT1 : in vitro and in silico evaluation of the realtionship between substrate, binding and translocation

    Omkvist, D. H., Feb 2011, Det Farmaceutiske Fakultet. 51 p.

    Research output: Book/ReportPh.D. thesisResearch

  14. Published

    Are marketed topical metronidazole creamas bioequivalent ? Evaluation by in vivo microdialysis sampling and tape stripping methodology

    Ortiz, P. G., Hansen, S. H., Shah, V. P., Sonne, J. & Benfeldt, E., 2011, In: Skin Pharmacology and Physiology (Print). 24, 1, p. 44-53

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Monitoring Lidocaine Single-Crystal Dissolution by Ultraviolet Imaging

    Østergaard, Jesper, Ye, F., Rantanen, Jukka, Yaghmur, Anan, Larsen, Susan Weng, Larsen, C. S. & Jensen, H., Aug 2011, In: Journal of Pharmaceutical Sciences. 100, 8, p. 3405-3410

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Development of solid-phase aziridine chemistries: Piperazine scaffolds and unnatural amino acid building blocks

    Ottesen, L. K., 2010, København: Det Farmaceutiske Fakultet. 139 p.

    Research output: Book/ReportPh.D. thesisResearch

  17. Published

    Ring opening of a resin-bound chiral aziridine with phenol nucleophiles

    Ottesen, L. K., Jaroszewski, J. W. & Franzyk, Henrik, 2010, In: Journal of Organic Chemistry. 75, 15, p. 4983-4991

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Selectively N-protected enantiopure 2,5-disubstituted piperazines: Avoiding the pitfalls in solid-phase Fukuyama-Mitsunobu cyclizations

    Ottesen, L. K., Olsen, Christian Adam, Witt, M., Jaroszewski, J. W. & Franzyk, Henrik, 2009, In: Chemistry: A European Journal. 15, 12, p. 2966-2978

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Development of an in vitro assay for the investigation of metabolism-induced drug hepatotoxicity

    Otto, M., Hansen, S. H., Dalgaard, L., Dubois, J. & Badolo, L., 2008, In: Cell Biology and Toxicology. 24, 1, p. 87-99

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Organ culture of C57BL/6 mouse arteries with LPS as an in vitro model of vascular inflammation

    Outzen, E. M., Mehryar, R., Boonen, H. C. M., Nielsen, A. S. & Sheykhzade, Majid, 28 Aug 2013. 1 p.

    Research output: Contribution to conferencePosterResearch

  21. Published

    A comparison of the effects of P-glycoprotein inhibitors on the blood-brain barrier permeation of cyclic prodrugs of an opioid peptide (DADLE)

    Ouyang, H., Andersen, T. E., Chen, W., Nofsinger, R., Steffansen, B. & Borchardt, R. T., 2009, In: Journal of Pharmaceutical Sciences. 98, 6, p. 2227-2236

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Factors that restrict intestinal cell permeation of cyclic prodrugs of an opioid peptide (DADLE): Part II. Role of metabolic enzymes in the intestinal mucosa

    Ouyang, H., Chen, W., Andersen, T. E., Steffansen, B. & Borchardt, R. T., 2009, In: Journal of Pharmaceutical Sciences. 98, 1, p. 349-361

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Factors that restrict the intestinal cell permeation of cyclic prodrugs of an opioid peptide (DADLE): Part I. Role of efflux transporters in the intestinal mucosa

    Ouyang, H., Chen, W., Andersen, T. E., Steffansen, B. & Borchardt, R. T., 2009, In: Journal of Pharmaceutical Sciences. 98, 1, p. 337-348

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Gold-embedded photosensitive liposomes for drug delivery: Triggering mechanism and intracellular release

    Paasonen, L., Sipilä, T., Subrizi, A., Laurinmäki, P., Butcher, S. J., Rappolt, M., Yaghmur, Anan, Urtti, A. & Yliperttula, M., 2010, In: Journal of Controlled Release. 147, p. 136-143

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    (1S, 3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a potent gamma-aminobutyric acid aminotransferase inactivator for the treatment of cocaine addiction

    Pan, Y., Gerasimov, M. R., Kvist, T., Wellendorph, Petrine, Madsen, K. K., Pera, E., Lee, H., Schousboe, Arne, Chebib, M., Bräuner, Hans, Craft, C. M., Brodie, J. D., Schiffer, W. K., Dewey, S. L., Miller, S. R. & Silverman, R. B., 1 Jan 2012, In: Journal of Medicinal Chemistry. 55, 1, p. 357-366

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Bioassay-guided identification and isolation of anticancer components in Hypholoma fasciculare extract

    Pang, W. S. K., Chen, M., Zhai, L. & Christensen, Søren Brøgger, 2008.

    Research output: Contribution to conferencePosterResearch

  27. Published

    Polycation cytotoxicity: a delicate matter for nucleic acid therapy - focus on polyethylenimine

    Parhamifar, L., Larsen, A. K., Hunter, A. C., Andresen, T. L. & Moghimi, S. M., 2010, In: Soft Matter. 6, p. 4001-4009

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Lactate dehydrogenase assay for assessment of polycation cytotoxicity

    Parhamifar, L., Andersen, H. & Moghimi, S. M., 2013, Nanotechnology for Nucleic Acid Delivery. Vol. 948. p. 13-22 10 p. (Methods in Molecular Biology).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  29. Published

    Doxycycline-coated sutures improve mechanical strength of intestinal anastomoses

    Pasternak, B., Rehn, M., Andersen, L., Ågren, M. S., Heegaard, Anne-Marie, Tengvall, P. & Aspenberg, P., 2008, In: International Journal of Colorectal Disease. 23, 3, p. 271-276

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Ecosystems emerging. 5: Constraints

    Patten, B. C., Straskraba, M. & Jørgensen, S. E., 2011, In: Ecological Modelling. 222, 16, p. 2945-2972

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    The structure of the complex between a branched pentasaccharide and Thermobacillus xylanilyticus GH-51 arabinofuranosidase reveals xylan-binding determinants and induced fit

    Paës, G., Skov, L. K., O'Donohue, M. J., Rémond, C., Kastrup, Jette Sandholm Jensen, Gajhede, Michael & Mirza, Osman Asghar, 2008, In: Biochemistry. 47, 28, p. 7441-7451

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Lithostratigraphy, geology and geochemisttry of the volcanic rocks of the Vaigat Formation on Disko and Nuussuaq, Paleocene of West Greenland

    Pedersen, Asger Ken, Larsen, L. M. & Pedersen, G. K., 2017, Copenhagen: The Geological Survey of Denmark and Greenland. 244 p. (Geological Survey of Denmark and Greenland (GEUS) Bulletin, Vol. 39).

    Research output: Book/ReportBookResearchpeer-review

  33. Published

    Physicochemical characteristics and in vitro release from oil-based vehicles of peptidomimetics: parenteral depots for intra-articular administration

    Pedersen, B. T., Østergaard, Jesper, Larsen, Susan Weng, Cornett, Claus, Ankersen, M. & Larsen, C. S., 2011, In: Drug Development and Industrial Pharmacy. 37, 1, p. 62-71

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    In vitro assessment of lidocaine release from aqueous and oil solutions and from preformed and in situ formed aqueos and oil suspensions. Parenteral depots for intra-articular administration

    Pedersen, B. T., Larsen, Susan Weng, Østergaard, Jesper & Larsen, C. S., 2008, In: Drug Delivery. 15, 1, p. 23-30

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    1,2,3-triazoles in peptidomimetic chemistry

    Pedersen, D. S. & Abell, A., May 2011, In: European Journal of Organic Chemistry. 2011, 13, p. 2399-2411

    Research output: Contribution to journalReviewResearchpeer-review

  36. Published

    A concise route to branched erythrono-gamma-lactones. Synthesis of the leaf-closing substance potassium (+/-)-(2R,3R)-2,3,4-trihydroxy-2-methylbutanoate

    Pedersen, D. S., Robinson, T. V., Taylor, D. K. & Tiekink, E. R. T., 2009, In: Journal of Organic Chemistry. 74, 11, p. 4400-4403

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Role of Cu2+ in oligomerization and aggregation of alzheimer's amyloid-β peptides

    Pedersen, J. T., 2012, København: Det Farmaceutiske Fakultetsbibliotek, Det Farmaceutiske Fakultet, Københavns Universitet. 85 p.

    Research output: Book/ReportPh.D. thesisResearch

  38. Published

    Rapid formation of a preoligomeric peptide-metal-peptide complex following copper(II) binding to amyloid β peptides

    Pedersen, J. T., Teilum, Kaare, Heegaard, N. H. H., Østergaard, Jesper, Adolph, H. & Hemmingsen, Lars Bo Stegeager, 2011, In: Angewandte Chemie International Edition. 50, 11, p. 2532-2535 4 p.

    Research output: Contribution to journalLetterResearchpeer-review

  39. Published

    Affinity capillary electrophoresis for identification and investigation of human Gc-globulin (vitamin D-binding protein) and its isoforms interacting with G-actin

    Pedersen, J. T., Østergaard, Jesper, Houen, G. & Heegaard, N. H. H., 2008, In: Electrophoresis. 29, 8, p. 1723-1733

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Cu(II) mediates kineticallyl distinct, non-amyloidogenic aggregation of amyloid-β peptides

    Pedersen, J. T., Østergaard, Jesper, Rozlosnik, N., Gammelgaard, Bente & Heegaard, N. H. H., 2011, In: Journal of Biological Chemistry. 286, 30, p. 26952-26963

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Subtype-specific suppression of Shiga toxin 2 released from Escherichia coli upon exposure to protein synthesis inhibitors

    Pedersen, M. G., Hansen, C., Riise, E., Persson, S. & Olsen, K. E. P., 2008, In: Journal of Clinical Microbiology. 46, 9, p. 2987-91

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Radioiododestannyllation of novel GHB neuroreceptor ligands

    Pedersen, M. H. F., Høg, S., Wellendorph, Petrine & Martiny, L., 2010, In: Journal of Labelled Compounds and Radiopharmaceuticals. 5-6, p. 318-320

    Research output: Contribution to journalConference articleResearchpeer-review

  43. Published

    African herbal medicine with CNS-activities: an early in vivo characterization

    Pedersen, M. E., 2008, København: Det Farmaceutiske Fakultet. 222 p.

    Research output: Book/ReportPh.D. thesisResearch

  44. Published

    A new screening strategy for CNS active plants by early in vivo characterization

    Pedersen, M. E., Vestergaard, H. T., Hansen, S. L., Bah, S., Stafford, G. I., van Staden, J., Nielsen, M. & Jäger, A. K., 2007.

    Research output: Contribution to conferencePosterResearch

  45. Published

    South African traditional medicine inhibits the spontaneous epileptiform discharges in slices of the mouse cerebral cortex

    Pedersen, M. E., Vestergaard, H. T., Stafford, G. I., van Staden, J. & Jäger, A. K., 2008.

    Research output: Contribution to conferencePosterResearch

  46. Published

    Amides from Piper capense with CNS activity: a preliminary SAR analysis

    Pedersen, M. E., Metzler, B., Stafford, G. I., van Staden, J., Jäger, A. K. & Rasmussen, H. B., 2009, In: Molecules. 14, 9, p. 3833-3843

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    The effect of extracts of Searsia species on epileptiform activity in slices of the mouse cerebral cortex

    Pedersen, M. E., Vestergaard, H. T., Stafford, G. I., van Staden, J. & Jäger, A. K., 2008, In: Journal of Ethnopharmacology. 119, 3, p. 538-541

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Effects of South African traditional medicine in animal models for depression

    Pedersen, M. E., Szewczyk, B., Stachowicz, K., Wieronska, J., Andersen, J., Stafford, G. I., van Staden, J., Pilc, A. & Jäger, A. K., 2008, In: Journal of Ethnopharmacology. 119, 3, p. 542-548

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Anticonvulsant effects of Searsia dentata (Anacardiaceae) leaf extract in rats

    Pedersen, M. E., Baldwin, R. A., Niquet, J., Stafford, G. I., van Staden, J., Wasterlain, C. G. & Jäger, A. K., 2010, In: Phytotherapy Research. 24, 6, p. 924-927

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Cinnamamides from Piper capense with affinity to the benzodiazepine site on the GABAA receptor

    Pedersen, M. E., Rasmussen, H. B., Metzler, B., Stafford, G. I., van Staden, J. & Jäger, A. K., 2008, In: Planta Medica. 74, 9, p. 1156 (PG34)

    Research output: Contribution to journalConference abstract in journalResearch