Involvement of the extracellular matrix and integrin signalling proteins in skeletal muscle glucose uptake

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  • Fulvia Draicchio
  • Volker Behrends
  • Neale A Tillin
  • Nicholas M Hurren
  • Sylow, Lykke
  • Richard Mackenzie

Whole-body euglycaemia is partly maintained by two cellular processes that encourage glucose uptake in skeletal muscle; 1) the insulin- and 2) contraction-stimulated pathways, with research suggesting convergence between these two previously separate processes. The normal structural integrity of the skeletal muscle requires an intact actin cytoskeleton as well as integrin-associated proteins, thus those structures are likely fundamental for effective glucose uptake in skeletal muscle. In contrast, excessive extracellular matrix (ECM) remodelling and integrin expression in skeletal muscle may contribute to insulin resistance owing to an increased physical barrier causing reduced nutrient and hormonal flux. This review paper explores the role of the ECM and the actin cytoskeleton in insulin- and contraction-mediated glucose uptake in skeletal muscle. This is a clinically important area of research given that defects in the structural integrity of the ECM and integrin-associated proteins may contribute to loss of muscle function and decreased glucose uptake in type 2 diabetes.

Original languageEnglish
JournalJournal of Physiology
Volume600
Issue number20
Pages (from-to)4393-4408
Number of pages16
ISSN0022-3751
DOIs
Publication statusPublished - 2022

Bibliographical note

This article is protected by copyright. All rights reserved.

    Research areas

  • Faculty of Science - Integrin, ILK, Rac1, ECM, Actin cytoskeleton, Muscle contraction, Insulin, Insulin resistance

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