Visualization and prediction of porosity in roller compacted ribbonswith near infrared chemical imaging (NIR-CI)

Research output: Contribution to journal › Journal article › Research › peer-review

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Visualization and prediction of porosity in roller compacted ribbonswith near infrared chemical imaging (NIR-CI). / Khorasani, Milad Rouhi; Amigo Rubio, Jose Manuel; Sonnergaard, Jørn; Olsen, P.; Bertelsen, P.; Rantanen, Jukka.

In: Journal of Pharmaceutical and Biomedical Analysis, Vol. 109, 2015, p. 11–17.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Khorasani, MR, Amigo Rubio, JM, Sonnergaard, J, Olsen, P, Bertelsen, P & Rantanen, J 2015, 'Visualization and prediction of porosity in roller compacted ribbonswith near infrared chemical imaging (NIR-CI)', Journal of Pharmaceutical and Biomedical Analysis, vol. 109, pp. 11–17. https://doi.org/10.1016/j.jpba.2015.02.008

APA

Khorasani, M. R., Amigo Rubio, J. M., Sonnergaard, J., Olsen, P., Bertelsen, P., & Rantanen, J. (2015). Visualization and prediction of porosity in roller compacted ribbonswith near infrared chemical imaging (NIR-CI). Journal of Pharmaceutical and Biomedical Analysis, 109, 11–17. https://doi.org/10.1016/j.jpba.2015.02.008

Vancouver

Khorasani MR, Amigo Rubio JM, Sonnergaard J, Olsen P, Bertelsen P, Rantanen J. Visualization and prediction of porosity in roller compacted ribbonswith near infrared chemical imaging (NIR-CI). Journal of Pharmaceutical and Biomedical Analysis. 2015;109:11–17. https://doi.org/10.1016/j.jpba.2015.02.008

Author

Khorasani, Milad Rouhi ; Amigo Rubio, Jose Manuel ; Sonnergaard, Jørn ; Olsen, P. ; Bertelsen, P. ; Rantanen, Jukka. / Visualization and prediction of porosity in roller compacted ribbonswith near infrared chemical imaging (NIR-CI). In: Journal of Pharmaceutical and Biomedical Analysis. 2015 ; Vol. 109. pp. 11–17.

Bibtex

@article{36896d62094447a5986771543cca39f1,
title = "Visualization and prediction of porosity in roller compacted ribbonswith near infrared chemical imaging (NIR-CI)",
abstract = "The porosity of roller compacted ribbon is recognized as an important critical quality attribute which has a huge impact on the final product quality. The purpose of this study was to investigate the use of near-infrared chemical imaging (NIR-CI) for porosity estimation of ribbons produced at different roll pressures. Two off-line methods were utilized as reference methods. The relatively fast method (oil absorption) was comparable with the more time-consuming mercury intrusion method (R2 = 0.98). Therefore, the oil method was selected as the reference off line method. It was confirmed by both reference methods that ribbons compressed at a higher pressure resulted in a lower mean porosity. Using NIR-CI in combination with multivariate data analysis it was possible to visualize and predict the porosity distribution of the ribbons. This approach is considered important for process monitoring and control of continuously operating roller compaction line.",
author = "Khorasani, {Milad Rouhi} and {Amigo Rubio}, {Jose Manuel} and J{\o}rn Sonnergaard and P. Olsen and P. Bertelsen and Jukka Rantanen",
year = "2015",
doi = "10.1016/j.jpba.2015.02.008",
language = "English",
volume = "109",
pages = "11–17",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
issn = "0731-7085",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Visualization and prediction of porosity in roller compacted ribbonswith near infrared chemical imaging (NIR-CI)

AU - Khorasani, Milad Rouhi

AU - Amigo Rubio, Jose Manuel

AU - Sonnergaard, Jørn

AU - Olsen, P.

AU - Bertelsen, P.

AU - Rantanen, Jukka

PY - 2015

Y1 - 2015

N2 - The porosity of roller compacted ribbon is recognized as an important critical quality attribute which has a huge impact on the final product quality. The purpose of this study was to investigate the use of near-infrared chemical imaging (NIR-CI) for porosity estimation of ribbons produced at different roll pressures. Two off-line methods were utilized as reference methods. The relatively fast method (oil absorption) was comparable with the more time-consuming mercury intrusion method (R2 = 0.98). Therefore, the oil method was selected as the reference off line method. It was confirmed by both reference methods that ribbons compressed at a higher pressure resulted in a lower mean porosity. Using NIR-CI in combination with multivariate data analysis it was possible to visualize and predict the porosity distribution of the ribbons. This approach is considered important for process monitoring and control of continuously operating roller compaction line.

AB - The porosity of roller compacted ribbon is recognized as an important critical quality attribute which has a huge impact on the final product quality. The purpose of this study was to investigate the use of near-infrared chemical imaging (NIR-CI) for porosity estimation of ribbons produced at different roll pressures. Two off-line methods were utilized as reference methods. The relatively fast method (oil absorption) was comparable with the more time-consuming mercury intrusion method (R2 = 0.98). Therefore, the oil method was selected as the reference off line method. It was confirmed by both reference methods that ribbons compressed at a higher pressure resulted in a lower mean porosity. Using NIR-CI in combination with multivariate data analysis it was possible to visualize and predict the porosity distribution of the ribbons. This approach is considered important for process monitoring and control of continuously operating roller compaction line.

U2 - 10.1016/j.jpba.2015.02.008

DO - 10.1016/j.jpba.2015.02.008

M3 - Journal article

C2 - 25746502

VL - 109

SP - 11

EP - 17

JO - Journal of Pharmaceutical and Biomedical Analysis

JF - Journal of Pharmaceutical and Biomedical Analysis

SN - 0731-7085

ER -

ID: 132337227