Time to full enteral feeding for very low-birth-weight infants varies markedly among hospitals worldwide but may not be associated with incidence of necrotizing enterocolitis: The NEOMUNE-NeoNutriNet Cohort Study
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Time to full enteral feeding for very low-birth-weight infants varies markedly among hospitals worldwide but may not be associated with incidence of necrotizing enterocolitis : The NEOMUNE-NeoNutriNet Cohort Study. / de Waard, Marita; Li, Yanqi; Zhu, Yanna; Ayede, Adejumoke I; Berrington, Janet; Bloomfield, Frank H; Busari, Olubunmi O; Cormack, Barbara E; Embleton, Nicholas D; van Goudoever, Johannes B; Greisen, Gorm; He, Zhongqian; Huang, Yan; Li, Xiaodong; Lin, Hung-Chih; Mei, Jiaping; Meier, Paula P; Nie, Chuan; Patel, Aloka L; Ritz, Christian; Sangild, Per Torp; Skeath, Thomas; Simmer, Karen; Tongo, Olukemi O; Uhlenfeldt, Signe S; Ye, Sufen; Ye, Xuqiang; Zhang, Chunyi; Zhou, Ping.
In: Journal of Parenteral and Enteral Nutrition, Vol. 43, No. 5, 2019, p. 658-667.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Time to full enteral feeding for very low-birth-weight infants varies markedly among hospitals worldwide but may not be associated with incidence of necrotizing enterocolitis
T2 - The NEOMUNE-NeoNutriNet Cohort Study
AU - de Waard, Marita
AU - Li, Yanqi
AU - Zhu, Yanna
AU - Ayede, Adejumoke I
AU - Berrington, Janet
AU - Bloomfield, Frank H
AU - Busari, Olubunmi O
AU - Cormack, Barbara E
AU - Embleton, Nicholas D
AU - van Goudoever, Johannes B
AU - Greisen, Gorm
AU - He, Zhongqian
AU - Huang, Yan
AU - Li, Xiaodong
AU - Lin, Hung-Chih
AU - Mei, Jiaping
AU - Meier, Paula P
AU - Nie, Chuan
AU - Patel, Aloka L
AU - Ritz, Christian
AU - Sangild, Per Torp
AU - Skeath, Thomas
AU - Simmer, Karen
AU - Tongo, Olukemi O
AU - Uhlenfeldt, Signe S
AU - Ye, Sufen
AU - Ye, Xuqiang
AU - Zhang, Chunyi
AU - Zhou, Ping
N1 - (CURIS 2018 NEXS 402) --> 2019 (Afventer endelig publicering + nyt CURIS-nr.) Publiceret online: 22.11.2018
PY - 2019
Y1 - 2019
N2 - Background: Transition to enteral feeding is difficult for very low-birth-weight (VLBW; ≤1500 g) infants, and optimal nutrition is important for clinical outcomes.Method: Data on feeding practices and short-term clinical outcomes (growth, necrotizing enterocolitis [NEC], mortality) in VLBW infants were collected from 13 neonatal intensive care units (NICUs) in 5 continents (n = 2947). Specifically, 5 NICUs in Guangdong province in China (GD), mainly using formula feeding and slow feeding advancement (n = 1366), were compared with the remaining NICUs (non-GD, n = 1581, Oceania, Europe, United States, Taiwan, Africa) using mainly human milk with faster advancement rates.Results: Across NICUs, large differences were observed for time to reach full enteral feeding (TFF; 8-33 days), weight gain (5.0-14.6 g/kg/day), ∆z-scores (-0.54 to -1.64), incidence of NEC (1%-13%), and mortality (1%-18%). Adjusted for gestational age, GD units had longer TFF (26 vs 11 days), lower weight gain (8.7 vs 10.9 g/kg/day), and more days on antibiotics (17 vs 11 days; all P < .001) than non-GD units, but NEC incidence and mortality were similar.Conclusion: Feeding practices for VLBW infants vary markedly around the world. Use of formula and long TFF in South China was associated with more use of antibiotics and slower weight gain, but apparently not with more NEC or higher mortality. Both infant- and hospital-related factors influence feeding practices for preterm infants. Multicenter, randomized controlled trials are required to identify the optimal feeding strategy during the first weeks of life.
AB - Background: Transition to enteral feeding is difficult for very low-birth-weight (VLBW; ≤1500 g) infants, and optimal nutrition is important for clinical outcomes.Method: Data on feeding practices and short-term clinical outcomes (growth, necrotizing enterocolitis [NEC], mortality) in VLBW infants were collected from 13 neonatal intensive care units (NICUs) in 5 continents (n = 2947). Specifically, 5 NICUs in Guangdong province in China (GD), mainly using formula feeding and slow feeding advancement (n = 1366), were compared with the remaining NICUs (non-GD, n = 1581, Oceania, Europe, United States, Taiwan, Africa) using mainly human milk with faster advancement rates.Results: Across NICUs, large differences were observed for time to reach full enteral feeding (TFF; 8-33 days), weight gain (5.0-14.6 g/kg/day), ∆z-scores (-0.54 to -1.64), incidence of NEC (1%-13%), and mortality (1%-18%). Adjusted for gestational age, GD units had longer TFF (26 vs 11 days), lower weight gain (8.7 vs 10.9 g/kg/day), and more days on antibiotics (17 vs 11 days; all P < .001) than non-GD units, but NEC incidence and mortality were similar.Conclusion: Feeding practices for VLBW infants vary markedly around the world. Use of formula and long TFF in South China was associated with more use of antibiotics and slower weight gain, but apparently not with more NEC or higher mortality. Both infant- and hospital-related factors influence feeding practices for preterm infants. Multicenter, randomized controlled trials are required to identify the optimal feeding strategy during the first weeks of life.
KW - Faculty of Science
KW - Antibiotics
KW - Formula
KW - Growth
KW - Milk
KW - NEC
KW - Parenteral
KW - Preterm infants
U2 - 10.1002/jpen.1466
DO - 10.1002/jpen.1466
M3 - Journal article
C2 - 30465333
VL - 43
SP - 658
EP - 667
JO - Journal of Parenteral and Enteral Nutrition
JF - Journal of Parenteral and Enteral Nutrition
SN - 0148-6071
IS - 5
ER -
ID: 209257910